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The A1 allele of the DRD2 gene (TaqI A polymorphisms) is associated with antisocial personality in a sample of alcohol-dependent patients

Published online by Cambridge University Press:  16 April 2020

G Ponce ,
M.A Jimenez-Arriero ,
G Rubio ,
J Hoenicka ,
I Ampuero ,
J.A Ramos  and
T Palomo
G Ponce
Affiliation:
Unidad de conductas adictivas, Servicio de Psiquiatría, Edificio de Medicina Comunitaria, Hospital Universitario 12 de Octubre, Avda de Córdoba s/n, 28041Madrid, Spain
M.A Jimenez-Arriero
Affiliation:
Unidad de conductas adictivas, Servicio de Psiquiatría, Edificio de Medicina Comunitaria, Hospital Universitario 12 de Octubre, Avda de Córdoba s/n, 28041Madrid, Spain
G Rubio*
Affiliation:
Unidad de conductas adictivas, Servicio de Psiquiatría, Edificio de Medicina Comunitaria, Hospital Universitario 12 de Octubre, Avda de Córdoba s/n, 28041Madrid, Spain
J Hoenicka
Affiliation:
Departamento de biología Molecular, Universidad Complutense, Madrid, Spain
I Ampuero
Affiliation:
Departamento de biología Molecular, Universidad Complutense, Madrid, Spain
J.A Ramos
Affiliation:
Departamento de biología Molecular, Universidad Complutense, Madrid, Spain
T Palomo
Affiliation:
Unidad de conductas adictivas, Servicio de Psiquiatría, Edificio de Medicina Comunitaria, Hospital Universitario 12 de Octubre, Avda de Córdoba s/n, 28041Madrid, Spain
*
*Corresponding author. E-mail address: garuva@inicia.es (G. Rubio).
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Abstract

Background. –

Presence of A1 allele of the DRD2 gene has been associated with a predisposition for alcoholism although there are limited data about its phenotypic expression in alcoholism.

Objectives. –

To determine the importance of the A1 allele in clinical variables of alcohol dependence.

Methodology. –

A sample of 103 alcohol-dependent males was studied. All patients were recruited consecutively from the general hospital and community settings. The diagnostics were made with the structured clinical interview for DSM-III-R (SCID); and the International Personality Disorder Examination (IPDE). Diagnosis of family alcoholism was made by direct interview or with the Research Diagnostic Criteria-Family History (RDC-FH). The Addiction Severity Index (ASI) and the Severity of Alcohol Dependence Scale (SADS) were used to assess alcohol dependence severity. Genotyping was done by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods.

Results. –

Approximately 39% of the sample carried the A1 allele (A1+ group). This group had higher prevalences of antisocial personality disorder (60% vs. 15.9%); and alcoholism family history (72.5% vs. 52.4%). Also A1+ had early onset alcohol abuse and more drinking problems. The presence of A1+ was the main factor to explain the diagnosis of antisocial personality disorder, but the weight of this factor was not sufficient to explain the complications assessed by the ASI.

Conclusions. –

Our results support the existence of an association between the A1 allele and factors resulting from dopaminergic deficiency, otherwise denominated reward deficiency syndrome.

Keywords

Alcohol use disorderDRD2A1 alleleAntisocial personality disorderOutcome
Type
Original article
Information
European Psychiatry , Volume 18 , Issue 7 , November 2003 , pp. 356 - 360
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS.

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