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Cerebral investigation of healthy siblings of schizophrenics

Published online by Cambridge University Press:  16 April 2020

A Mourot ,
T d'Amato ,
T Rochet ,
M Marie-Cardine ,
C Artéaga ,
JP Martin  and
J Dalery
A Mourot
Affiliation:
CHS de Saint-Avé, 56890Saint-Avé, France
T d'Amato
Affiliation:
CHS le Vinatier, 69677Bron, France
T Rochet
Affiliation:
CHS le Vinatier, 69677Bron, France
M Marie-Cardine
Affiliation:
CHS le Vinatier, 69677Bron, France
C Artéaga
Affiliation:
Hôpital d'Instruction des Armées de Desgenettes, 69003Lyon, France
JP Martin
Affiliation:
Hôpital d'Instruction des Armées de Desgenettes, 69003Lyon, France
J Dalery
Affiliation:
CHS le Vinatier, 69677Bron, France
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Summary

Computed tomography (CT) studies have demonstrated that lateral ventricular size measured by ventricular brain ratio (VBR), as well as third ventricle width, is statistically enlarged in schizophrenics. Moreover, these cerebral abnormalities differ according to symptomatology evaluated with a positive and negative symptom scale. The aim of this study was to investigate, using CT scans, healthy siblings of schizophrenics, and relate the results to their ill siblings. Nineteen healthy siblings of 12 previously studied schizophrenics underwent CT scans, which were compared to those of their related schizophrenic sibling and to 17 unrelated control subjects. The results showed that in ten of 12 families, schizophrenics have larger ventricles (lateral and third ventricles) than their healthy siblings. Ventricular enlargement of healthy siblings was correlated with severity of negative symptoms of their ill sibling. Implications of a familial contribution for ventricular size and negative symptoms are discussed.

Keywords

CT scanventricular brain ratiothird ventricleschizophrenianegative symptoms
Type
Original article
Information
European Psychiatry , Volume 12 , Issue 6 , 1997 , pp. 273 - 278
Copyright
Copyright © European Psychiatric Association 1997

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