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Clinical outcome and olanzapine plasma levels in acute schizophrenia

Published online by Cambridge University Press:  16 April 2020

M.C. Mauri ,
CPC Steinhilber ,
R. Marino ,
E. Invernizzi ,
A. Fiorentini ,
G. Cerveri ,
M.L. Baldi  and
F. Barale
M.C. Mauri*
Affiliation:
Clinical Psychiatry, Clinical Neuropsychopharmacology Unit, University of Milan, IRCCS Ospedale Maggiore, Via F. Sforza 35, 20122 Milan, Italy
CPC Steinhilber
Affiliation:
Clinical Psychiatry, University of Pavia, IRCCS Policlinico S. Matteo, Pavia, Italy
R. Marino
Affiliation:
Clinical Psychiatry, University of Pavia, IRCCS Policlinico S. Matteo, Pavia, Italy
E. Invernizzi
Affiliation:
Clinical Psychiatry, University of Pavia, IRCCS Policlinico S. Matteo, Pavia, Italy
A. Fiorentini
Affiliation:
Clinical Psychiatry, Clinical Neuropsychopharmacology Unit, University of Milan, IRCCS Ospedale Maggiore, Via F. Sforza 35, 20122 Milan, Italy
G. Cerveri
Affiliation:
Clinical Psychiatry, Clinical Neuropsychopharmacology Unit, University of Milan, IRCCS Ospedale Maggiore, Via F. Sforza 35, 20122 Milan, Italy
M.L. Baldi
Affiliation:
Legal Medicine and Toxicology Service, IRCCS Policlinico S. Matteo, Pavia, Italy
F. Barale
Affiliation:
Clinical Psychiatry, University of Pavia, IRCCS Policlinico S. Matteo, Pavia, Italy
*
*Corresponding author. E-mail address: maurimc@policlinico.mi.it (M.C. Mauri).
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Abstract

Purpose

This open label study was performed to evaluate the relationship between the plasma concentration of olanzapine and the response in acute schizophrenic inpatients.

Material and methods

A total of 54 inpatients, 38 males and 16 females, age ranging from 18 to 75 years, affected by Schizophrenia (DSM IV criteria) during an exacerbation phase were included in the study. Olanzapine (OLZ) was started at a dose of 5–20 mg/day and was increased to a mean dose of 15.27 mg ±5.53 S.D. Patients were evaluated at baseline, and after 2 weeks, by using BPRS, PANNS, HRS-D, EPSE, and ACS.

Results

BPRS and total PANSS showed a statistically significant improvement at the end of the study. Olanzapine plasma levels (PL) ranged from 5 to 120 ng/ml (mean 33.15 ng/ml ± 28.28 S.D.) and showed a positive correlation with OLZ dosage. A significant curvilinear correlation between OLZ PL and clinical improvement (BPRS, PANSS and HRS-D percent of amelioration) was observed.

Conclusion

Olanzapine plasma level determination seems to be a useful tool in optimizing acute treatment particularly for more problematic cases.

Keywords

Acute schizophreniaOlanzapinePlasma levels
Type
Original article
Information
European Psychiatry , Volume 20 , Issue 1 , January 2005 , pp. 55 - 60
Copyright
Copyright © Elsevier SAS 2005

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