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Famotidine: a supplemental drug for the treatment of schizophrenia

Published online by Cambridge University Press:  16 April 2020

PN Dannon
Affiliation:
Division of Psychiatry, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Israel
E Lepkifker*
Affiliation:
Division of Psychiatry, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Israel
I Iancu
Affiliation:
Division of Psychiatry, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Israel
R Ziv
Affiliation:
Division of Psychiatry, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Israel
N Horesh
Affiliation:
Division of Psychiatry, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Israel
*
*Correspondence and reprints.
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Summary

In an open-label study, famotidine was added to the regular neuroleptic regimen of 11 schizophrenic patients for 4 weeks. Each patient was scored weekly with SAPS, SANS, CGI and HAM-D-17 scales. The results suggest that famotidine is indeed effective as an adjunctive drug to neuroleptics in the treatment of schizophrenia.

Type
Rapid Communication
Copyright
Copyright © European Psychiatric Association 1997

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References

Carpenter, W., Buchanan, R. Schizophrenia (A Review). N Engl J Med 1994; 330: 681688CrossRefGoogle Scholar
Chermos, AN. Pharmacodynamics of famotidine in humans. Am J Med 84suppl 4B1986 37CrossRefGoogle Scholar
Deutsch, SI, Rosse, RB, Kendrick, KA, Fay-McCarthy, M, et al.. Famotidine adjunctive pharmacotherapy for schizophrenia: preliminary data. Clin Neuropharmacol 1993; 16: 51852410.1097/00002826-199312000-00005CrossRefGoogle ScholarPubMed
Hough, LB. Cellular localization and possible functions for brain histamine: recent progress. Prog Neurohiol 1988; 30: 46950510.1016/0301-0082(88)90032-9CrossRefGoogle ScholarPubMed
Kaminsky, R, Moriarty, TM, Bodine, J, Wolf, DE, Davidson, M. Effect of famotidine on deficit symptoms of schizophrenia. Lancet 1989; 335: 1351135210.1016/0140-6736(90)91237-5CrossRefGoogle Scholar
Rifkin, A. Pharmacological strategies in the treatment of schizophrenia. Psych Clin of North America 1993; 16: 351362CrossRefGoogle Scholar
Rosse, RB, Kendrick, K, Fay-McCarthy, M, Prell, GD, et al.. An open-label study of the therapeutic efficacy of high-dose famotidine adjuvant pharmacotherapy in schizophrenia: preliminary evidence for treatment efficacy. Clin Neuropharmacol 1996; 19: 34134810.1097/00002826-199619040-00007CrossRefGoogle ScholarPubMed
White, JM, Rumbold, CR. Behavioral effects of histamine and its antagonists: a review. Psychopharmacology 1988; 95: 1410.1007/BF00212757CrossRefGoogle ScholarPubMed
Yoshimolo, K, Saima, S, Echizen, H, Nakamura, Y, et al.. Famotidine-associated CNS reactions and plasma and CS drug concentrations in neurosurgical patients with renal failure. Clin Pharmacol Ther 1994; 55: 693s70010.1038/clpt.1994.86CrossRefGoogle Scholar
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