Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-25T18:49:44.791Z Has data issue: false hasContentIssue false
  • English
  • Français

Oral Disease in Relation to Future Risk of Dementia and Cognitive Decline: Prospective Cohort Study Based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (Advance) Trial

Published online by Cambridge University Press:  02 October 2011

G.-D. Batty ,
Q. Li ,
R. Huxley ,
S. Zoungas ,
B.-A. Taylor ,
B. Neal ,
B. de Galan ,
M. Woodward ,
S.-B. Harrap  and
S. Colagiuri
...Show all authors
G.-D. Batty*
Affiliation:
Department of Epidemiology and Public Health, University College of London, Torrington Place, London, UK The George Institute for International Health, University of Sydney, Sydney, Australia Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK Medical Research Council Social and Public Health Sciences Unit, Glasgow, UK
Q. Li
Affiliation:
The George Institute for International Health, University of Sydney, Sydney, Australia
R. Huxley
Affiliation:
The George Institute for International Health, University of Sydney, Sydney, Australia
S. Zoungas
Affiliation:
The George Institute for International Health, University of Sydney, Sydney, Australia School of Public Health, Monash University, Melbourne, Australia
B.-A. Taylor
Affiliation:
Department of Oral Biology, University of Oslo, Oslo, Norway
B. Neal
Affiliation:
The George Institute for International Health, University of Sydney, Sydney, Australia
B. de Galan
Affiliation:
The George Institute for International Health, University of Sydney, Sydney, Australia Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
M. Woodward
Affiliation:
The George Institute for International Health, University of Sydney, Sydney, Australia Mount Sinai School of Medicine, New York, United States
S.-B. Harrap
Affiliation:
Department of Physiology, University of Melbourne, Melbourne, Australia
S. Colagiuri
Affiliation:
Institute of Obesity, Nutrition and Exercise, University of Sydney, Sydney, Australia
A. Patel
Affiliation:
The George Institute for International Health, University of Sydney, Sydney, Australia
J. Chalmers
Affiliation:
The George Institute for International Health, University of Sydney, Sydney, Australia
*
⁎Corresponding author. E-mail address: david.batty@ucl.ac.uk (G.-D. Batty).
Get access

Abstract

Objective

Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes.

Methods

A total of 11,140 men and women aged 55–88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up.

Results

Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes.

Conclusions

Tooth loss was associated with an increased risk of both dementia and cognitive decline.

Keywords

Cognitive declineCohort studyDementiaOral disease
Type
Short communication
Information
European Psychiatry , Volume 28 , Issue 1 , January 2013 , pp. 49 - 52
Copyright
Copyright © European Psychiatric Association 2013

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychological Association. Diagnostic and statistical manual of mental disorders. Washington DC: American Psychological Association; 1994.Google Scholar
Study rationale and design of ADVANCE: action in diabetes and vascular disease--preterax and diamicron MR controlled evaluation. Diabetologia 2001;44(9):1118–1120.CrossRefGoogle Scholar
Bahekar, A.A.Singh, S.Saha, S.Molnar, J.Arora, R.The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta-analysis. Am Heart J 2007;154(5):830–837.CrossRefGoogle ScholarPubMed
Carcaillon, L.Peres, K.Pere, J.J.Helmer, C.Orgogozo, J.M.Dartigues, J.F.Fast cognitive decline at the time of dementia diagnosis: a major prognostic factor for survival in the community. Dement Geriatr Cogn Disord 2007;23(6):439–445.CrossRefGoogle Scholar
Chauncey, H.H.Muench, M.E.Kapur, K.K.Wayler, A.H.The effect of the loss of teeth on diet and nutrition. Int Dent J 1984;34(2):98–104.Google ScholarPubMed
Crum, R.M.Anthony, J.C.Bassett, S.S.Folstein, M.F.Population-based norms for the Mini-Mental State Examination by age and educational level. JAMA 1993;18:2386–2391.CrossRefGoogle Scholar
Gatz, M.Mortimer, J.Fratiglioni, L.Potentially modifiable risk factors for dementia in identical twins. Alzheimer Dementia 2006;2:110–117.CrossRefGoogle ScholarPubMed
Jones, J.A.Lavallee, N.Alman, J.Sinclair, C.Garcia, R.I.Caries incidence in patients with dementia. Gerodontology 1993;10(2):76–82.CrossRefGoogle ScholarPubMed
Kamer, A.R.Craig, R.G.Dasanayake, A.P.Brys, M.Glodzik-Sobanska, L.de Leon, M.J.Inflammation and Alzheimer's disease: possible role of periodontal diseases. Alzheimers Dementia 2008;4(4):242–250.CrossRefGoogle ScholarPubMed
Kamer, A.R.Craig, R.G.Pirraglia, E.TNF-alpha and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects. J Neuroimmunol 2009;216(1–2):92–97.CrossRefGoogle ScholarPubMed
Kim, J.M.Stewart, R.Prince, M.Dental health, nutritional status and recent-onset dementia in a Korean community population. Int J Geriatr Psychiatry 2007;22(9):850–855.CrossRefGoogle Scholar
Kind, P.Dolan, P.Gudex, C.Williams, A.Variations in population health status: results from a United Kingdom national questionnaire survey. BMJ 1998;316(7133):736–741.CrossRefGoogle ScholarPubMed
Kondo, K.Niino, M.Shido, K.A case-control study of Alzheimer's disease in Japan-significance of life-styles. Dementia 1994;5(6):314–326.Google ScholarPubMed
Li, Q.Chalmers, J.Czernichow, S.Oral disease and subsequent cardiovascular disease in people with type 2 diabetes: a prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial. Diabetologia 2010;53(11):2320–2327.CrossRefGoogle ScholarPubMed
Luchsinger, J.A.Mayeux, R.Dietary factors and Alzheimer's disease. Lancet Neurol 2004;3(10):579–587.CrossRefGoogle ScholarPubMed
Noble, J.M.Borrell, L.N.Papapanou, P.N.Elkind, M.S.Scarmeas, N.Wright, C.B.Periodontitis is associated with cognitive impairment among older adults: analysis of NHANES-III. J Neurol Neurosurg Psychiatry 2009;80(11):1206–1211.CrossRefGoogle ScholarPubMed
Okamoto, N.Morikawa, M.Okamoto, K.Relationship of tooth loss to mild memory impairment and cognitive impairment: findings from the Fujiwara-kyo study. Behav Brain Funct 2010;6:77.CrossRefGoogle ScholarPubMed
Patel, A.MacMahon, S.Chalmers, J.Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. Lancet 2007;370(9590):829–840.CrossRefGoogle ScholarPubMed
Patel, A.MacMahon, S.Chalmers, J.Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008;358(24):2560–2572.Google ScholarPubMed
Rosendorff, C.Beeri, M.S.Silverman, J.M.Cardiovascular risk factors for Alzheimer's disease. Am J Geriatr Cardiol 2007;16(3):143–149.CrossRefGoogle ScholarPubMed
Shimazaki, Y.Soh, I.Saito, T.Influence of dentition status on physical disability, mental impairment, and mortality in institutionalized elderly people. J Dent Res 2001;80(1):340–345.CrossRefGoogle ScholarPubMed
Ship, J.A.Puckett, S.A.Longitudinal study on oral health in subjects with Alzheimer's disease. J Am Geriatr Soc 1994;42(1):57–63.CrossRefGoogle ScholarPubMed
Stein, P.S.Desrosiers, M.Donegan, S.J.Yepes, J.F.Kryscio, R.J.Tooth loss, dementia and neuropathology in the Nun study. J Am Dent Assoc 2007;138(10):1314–1322.CrossRefGoogle ScholarPubMed
Stein, P.S.Kryscio, R.J.Desrosiers, M.Donegan, S.J.Gibbs, M.B.Tooth loss, apolipoprotein E, and decline in delayed word recall. J Dent Res 2010;89(5):473–477.CrossRefGoogle ScholarPubMed
Stewart, R.Masaki, K.Xue, Q.L.A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study. Arch Neurol 2005;62(1):55–60.CrossRefGoogle ScholarPubMed
The EuroQol Group. EuroQol-a new facility for the measurement of health-related quality of life. Health Policy 1990;16(3):199–208.CrossRefGoogle Scholar
Watts, A.Crimmins, E.M.Gatz, M.Inflammation as a potential mediator for the association between periodontal disease and Alzheimer's disease. Neuropsychiatr Dis Treat 2008;4(5):865–876.CrossRefGoogle ScholarPubMed
You, Z.Cushman, M.Jenny, N.S.Howard, G.Tooth loss, systemic inflammation, and prevalent stroke among participants in the reasons for geographic and racial difference in stroke (REGARDS) study. Atherosclerosis 2009;203(2):615–619.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.