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The reduction of alcohol consumption with novel pharmacological intervention

Published online by Cambridge University Press:  16 April 2020

W Sperling  and
O.M. Lesch
W Sperling
Affiliation:
Department of Psychiatry, Friedrich Alexander University of Erlangen, Schwabachanlage 6-10, 91054Erlangen, Germany
O.M. Lesch
Affiliation:
Department of Psychiatry, Universily of Vienna, Vienna, Austria
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Summary

The development of pharmacological agents in treating alcoholism represents one of many different ways to suppress alcohol intake. Regarding the hypothetical involvement of different neurochemical systems in “alcohol craving”, specific substances have been examined in animals models (especially rats) and increasingly in man. Promising results in reducing “alcohol craving” were described in the use of different kinds of chemical substances. “Craving” therefore can hardly be explained on the basis of a deficit in only one neurochemical (neurotransmitter) system. This conclusion is supported by the data. The efficiacy of many anti-craving substances described in smaller studies must first be confirmed in clinical studies on a wider scale.

Keywords

cravingalcoholismserotoninopioidslithiumacamprosat
Type
Review
Information
European Psychiatry , Volume 11 , Issue 5 , 1996 , pp. 217 - 226
Copyright
Copyright © Elsevier, Paris 1996

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