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Sporadic schizophrenia — another male preserve?

Published online by Cambridge University Press:  16 April 2020

RM Murray  and
P Jones
RM Murray
Affiliation:
Department of Psychological Medicine, Institute of Psychiatry and Kings College Hospital, De Crespigny Park, LondonSE5 8AF, UK
P Jones
Affiliation:
Department of Psychological Medicine, Institute of Psychiatry and Kings College Hospital, De Crespigny Park, LondonSE5 8AF, UK
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Summary

The proposed distinction between familial and sporadic schizophrenia has proved a useful tool for research into the aetiology of the disorder although evidence for the proposed association between large cerebral ventricles and the sporadic form has been contradictory. We have reviewed the literature and found evidence that in the context of brain structure, the familial — sporadic distinction may apply to men but not women with schizophrenia. This may explain some of the observed sex differences in schizophrenia and some of the confusion in the literature. Based upon this review, we examined our own data on 138 schizophrenic subjects with no family history (sporadic) and 24 with such a history (familial). As predicted, cerebral ventricle size was largest in men with sporadic schizophrenia, there being no effect in women. We propose a meta-analysis of existing data in order to pursue this phenomenon further.

Keywords

schizophreniasex differencescerebral ventricle
Type
Original article
Information
European Psychiatry , Volume 11 , Issue 6 , 1996 , pp. 286 - 288
Copyright
Copyright © Elsevier, Paris 1996

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References

Andreasen, NC, Swayze, VW, Flaum, M, Yates, WR, Arndt, S, McChesney, CVentricular enlargement in schizophrenia evaluated with computed tomographic scanning Arch Gen Psychiatry 1990 47 1008–1015CrossRefGoogle ScholarPubMed
Castle, DJ, Murray, RMThe neurodevelopmental basis of sex differences in schizophrenia Psycholog Med 1991 21 565–575CrossRefGoogle Scholar
Castle, DJ, Wessely, S, Murray, RMSex and schizophrenia Br J Psychiatry 1993 162 658–664CrossRefGoogle Scholar
Cazullo, CL, Sacchetti, E, Vita, A, et al.Cerebral ventricular size in schizophrenic spectrum disorders: relationship to clinical, neuropsychological and immunogenetic variablesShagass, C, et al.Biological Psychiatry AmsterdamElsevier Science Publishers 1985 1060–1062Google Scholar
Cloninger, CRTurning point in the design of linkage studies Neuropsychiatr Genetics 1994 54 83–92CrossRefGoogle ScholarPubMed
Farmer, A, Jackson, R, McGuffin, P, Storey, PCerebral ventricular enlargement in chronic schizophrenia Br J Psychiatry 1987 150 324–330CrossRefGoogle ScholarPubMed
Goldstein, JM, Faraone, SV, Chen, WJ, Tsuang, MTGender the familial risk for schizophrenia. Disentangling the confounding factors Schizophren Res 1992 7 135–140CrossRefGoogle ScholarPubMed
Golier, JAFamilial risk of schizophrenia and ventricular size on CT. Poster presented at the Society of Biological Psychiatry Philadelphia, PA, USA. May 18–22, 1994Google Scholar
Harvey, I, Ron, MA, Du Boulay, G, Lewis, SW, Murray, RMReduction of cortical volume in schizophrenia on MRI Psycholog Med 1993 23 591–604CrossRefGoogle Scholar
Iacono, WG, Beiser, MAre males more likely than females to develop schizophrenia? Am J Psychiatry 1992 149 1070–1074Google ScholarPubMed
Johnstone, EC, Owens, DG, Bydder, G, Colter, N, Crow, TJ, Frith, CDThe spectrum of structural brain changes in schizophrenia: age of onset as a predictor of cognitive and clinical function and their cerebral correlates Psycholog Med 1989 19 91–103CrossRefGoogle ScholarPubMed
Jones, PB, Owen, MJ, Lewis, SW, Murray, RMA case control study of family history and cerebral cortical abnormalities in schizophrenia Acta Psychiatr Scand 1993 87 6–12CrossRefGoogle Scholar
Jones, PB, Harvey, I, Lewis, SW, et al.Cerebral ventricle dimensions as risk factors for schizophrenia affective psychosis. An epidemiological approach to analysis Psychol Med 1994 24 4 995–1011CrossRefGoogle Scholar
Kaiya, H, Uematsu, M, Ofuji, M, Nishida, A, Morikiyo, M, Adachi, SComputerized tomography in schizophrenia: familial versus non familial forms of illness Br J Psychiatry 1989 155 444–450CrossRefGoogle Scholar
Kemali, C, Maj, M, Galderisi, S, et al.Clinical, biological and neuropsychological features associated with lateral ventricular enlargement in DSM-III schizophrenic disorder Psychiatry Res 1986 21 137–149CrossRefGoogle Scholar
Lewis, SW, Reveley, AM, Reveley, MA, Murray, RMThe familial-sporadic distinction as a strategy in schizophrenia research Br J Psychiatry 1987 151 306–313CrossRefGoogle ScholarPubMed
Murray, RM, Lewis, SW, Reveley, AMTowards and aetiological classification of schizophrenia Lancet 1985 i 1023–1026CrossRefGoogle Scholar
Nasrallah, HA, Kuperman, S, Hamra, BJ, McCalley-Whitters, MClinical differences between schizophrenic patients with and without large cerebral ventricles J Clin Psychiatry 1982 44 407–409Google Scholar
Nimgaonkar, VL, Wessely, S, Murray, RMPrevalence of familiality, obstetric complications and structural brain damage in schizophrenic patients Br J Psychiatry 1988 153 191–197CrossRefGoogle ScholarPubMed
Owens, DG, Johnstone, EC, Crow, TJ, Frith, CD, Jagoe, JR, Kreel, LLateral ventricular size in schizophrenia —relationship to the disease process and its clinical manifestations Psycholog Med 1985 15 27–41CrossRefGoogle ScholarPubMed
Owen, MJ, Lewis, SW, Murray, RMFamily history and ventricular enlargement in schizophrenia –a case control study Br J Psychiatry 1989 154 629–634CrossRefGoogle ScholarPubMed
Pearlson, GD, Garbacz, DJ, Moberg, PJ, Ahn, HS, DePaulo, JRSymptomatic, familial, perinatal and social correlates of computerized axial tomography (CAT) changes in schizophrenics and bipolars J Nerv Mental Dis 1985 173 42–50CrossRefGoogle ScholarPubMed
Pearlson, GD, Kim, WS, Kubos, KL, et al.Ventricle-brain ratio, computed tomographic density, and brain area in 50 schizo-phrenics Arch Gen Psychiatry 1989 46 690–697CrossRefGoogle Scholar
Polymeropoulos, MH, Coon, H, Byerley, W, et al.Search for a schizophrenia locus on human chromosome 22 Neuropsy-chiatr Gen 1994 54 9–100Google ScholarPubMed
Pulver, AE, Brown, CH, Wolyniec, P, et al.Schizophrenia: age at onset, gender and familial risk Acta Psychiatr Scand 1990 82 344–351CrossRefGoogle ScholarPubMed
Reddy, R, Mukherjee, S, Schnur, DFamily history of psychosis, obstetric complications, premorbid functioning and CT scan findings in schizophrenic patients Schizophr Res 1989 2 19CrossRefGoogle Scholar
Reveley, AM, Reveley, MA, Murray, RMCerebral ventricular enlargement in non-genetic schizophrenia: a controlled twin study Br J Psychiatry 1984 144 89–93CrossRefGoogle ScholarPubMed
Romani, A, Merello, S, Gozzoli, L, Zerbi, F, Grassi, M, Cosi, VP300 and CT scans in patients with chronic schizophrenia Br J Psychiatry 1987 151 506–513CrossRefGoogle ScholarPubMed
Schwarzkopf, SB, Nasrallah, HA, Olson, SC, Bogerts, B, McLaughlan, JA, Mitra, TFamily history and brain morphology in schizophrenia: an MRI study Psychiatry Res Neuroimag 1991 40 49–60CrossRefGoogle Scholar
Sham, PC, Bebbington, P, Jones, PB, et al.The Camberwell Functional Psychosis Family Study. Age at onset, gender and familial morbidity in schizophrenia Br J Psychiatry 1994 165 466–473CrossRefGoogle Scholar
Romani, A, Merrelo, S, Gozzoli, L, Zerbi, F, Grassi, M, Cosi, VP300 and CT scan in patients with chronic schizophrenia Br J Psychiatry 1987 151 506–513CrossRefGoogle ScholarPubMed
Turner, SW, Toone, BK, Brett-Jones, JRComputerised tomographic scan changes in early schizophrenia —preliminary findings Psycholog Med 1986 16 219–225CrossRefGoogle Scholar
Vita, A, Dieci, GM, Giobbio, M, Morganti, C, Braga, M, Invernizzi, GA reconsideration of the relationship between cerebral structural abnormalities and family history of schizophrenia Psychiatry Res 1994 53 41–57CrossRefGoogle ScholarPubMed
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