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Zopiclone's residual effects on psychomotor and information processing skills involved in complex tasks such as car driving: a critical review

Published online by Cambridge University Press:  16 April 2020

JF O'Hanlon
JF O'Hanlon*
Affiliation:
Institute for Human Psychophamacology, University of Limburg, Abtstraat 2A, 6211 LS, Maastricht, The Netherlands
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Summary

Before and after its introduction in 1987, zopiclone was the object of investigation in 16 psychometric studies employing both healthy volunteers and insomniac patients. Their common purpose was to determine whether nocturnal doses (usually the standard 7.5 mg) possess residual sedative effects that interfere with skilled safety-relevant performance, such as car driving, over the following day. Most studies have found no residual effects. Those that did, have shown them to be modest in magnitude and not to persist for longer than about 12 hours from the time of dosage. Without altering the general conclusion that zopiclone possesses few if any residual effects of clinical relevance, it must be said that the studies reviewed failed to meet current methodological standards and may have left some important questions unanswered.

Keywords

zopiclonepsychomotor performanceresidual hypnotic effectsdriving
Type
Research Article
Information
European Psychiatry , Volume 10 , Issue S3: Satellite Symposium to the AEP Congress , 1995 , pp. 137s - 143s
Copyright
Copyright © Elsevier, Paris 1995

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References

Angst, JBorbely, AEngel, RR, et al. Report on the Sixth Consensus Conference on the Methodology of Clinical Trials with Hypnotic Drugs. Pharmacopsychiat 1995;28: 2–7CrossRefGoogle ScholarPubMed
Billiard, MDaytime repercussions of hypnotics: the example of zopiclone. In: Grivois, H, et al. Zopiclone 1987–1992, 5 years of clinical practice Paris: Elsevier, 1993 83–92Google Scholar
Billiard, MBesset, Ade Lustrac, CBrissaud, LDose-response effects of zopiclone on night sleep on nighttime and daytime functioning. Sleep 1987; 10(suppl 1):27–34CrossRefGoogle ScholarPubMed
Billiard, MBesset, Ade Lustrac, CBrissaud, LCadilhac, JEffets de la zopiclone sur le sommeil, la somnolence diurne et les performances nocturnes et diurnes chez le volontaire sain. Neurophysiol Clin 1989; 19: 131–43CrossRefGoogle Scholar
Broadhurst, ACushnaghan, RCResidual effects of zopiclone (Imovane). Sleep 1987; 10(suppl I):48–53Google ScholarPubMed
Dehlin, ORundgren, ABörjesson, L, et al. Zopiclone to geriatric patients. A parallel double-blind dose response clinical trial. In: Nicholson, ANSchlosberg, ADreyfus, JF ed. Zopiclone: a third generation of hypnotics Basel: Karger, 1983 173–8Google Scholar
Gorenstein, CTavares, SMGentil, VPères, CMoreno, RADreyfus, JFPsychophysiological effects dose equivalence of zopiclone and triazolam administered to healthy volunteers. Methodological considerations. Braz J Med Biol Res 1990; 23: 941–51Google ScholarPubMed
Griffiths, ANJones, DMRichens, AZopiclone produces effects on human performance similar to flurazepam, lormetazepam and triazolam. Br J Clin Pharmacol 1986; 21: 647–53Google ScholarPubMed
Harrison, CSubhan, ZHindmarch, IResidual effects of zopiclone and benzodiazepine hypnotics on psychomotor performance related to car driving. Drugs Exp Clin Res XI(12)1985 823–9Google Scholar
Hindmarch, IImmediate and overnight effects of zopiclone 75 mg and nitrazepam 5 mg with ethanol on psychomotor performance and memory in healthy volunteers, Int. Clin Psychopharmacol 1990; 5(suppl 2):105–14Google Scholar
Kuitunen, TMattila, MJSeppälä, TActions and interactions of hypnotics on human performance: single doses of zopiclone, triazolam and alcohol. Br J Clin Pnarmacol 1990; 30: 453–61CrossRefGoogle Scholar
Lader, MDenney, SCA double-blind study to establish the residual effects of zopiclone on performance in healthy volunteers. Int Pharmacopsychiat 1982; 17(suppl 1):98–108Google ScholarPubMed
Lemperiere, TSarrazin, AFeline, A, et al. Etude de la vigilance après prise de zopiclone en comparaison avec nitrazepam et placebo. L'Encéphale 1980; 11: 23–35Google Scholar
Louwerens, JWGloerich, ABMde Vries, GBrookhuis, KAO'Hanlon, JFThe relationship between drivers' blood alcohol concentration and actual driving performance during high speed travel. In: Nordzij, PCRoszbach, R ed. Alcohol, Drugs and Traffic Safety -T86 Amsterdam: Excerpta Medica, 1987 183–6Google Scholar
Malmelack, MBuck, LCsima, APrice, VSmiley, AEffects of flurazepam and zopiclone on the performance of chronic insomniac patients: a study of ethanol-drug interaction. Sleep 1987; 10(suppl 1):79–87Google Scholar
Mizuki, YHirano, HMiyoshi, A, et al. Residual effects of zopiclone on subsequent daytime functions in normal humans. Hum Psychopharmacol 1987; 2: 119–26CrossRefGoogle Scholar
Monchesky, TCBillings, BJPhillips, RBourgouin, JZopiclone in insomniac shiftworkers. Arch Occup Environ Health 1989; 6: 255–9Google Scholar
Moon, CALHindmarch, IHolland, RLThe effects of zopiclone 7.5 mg on the sleep, mood and performance of shift workers. Int Clin Psychopharmacol 1990; 5(suppl 2):79–83Google ScholarPubMed
Nicholson, ANStone, BMZopiclone; sleep and performance studies in healthy man. Int Psychopharmacol 1982; 17(suppl 2):92–7Google ScholarPubMed
Nicholson, ANStone, BMEfficacy of zopiclone in middle age. Sleep 1987; 10(suppl 1):35–9CrossRefGoogle ScholarPubMed
Ponciano, EFreitas, FCamara, JFaria, MBarreto, MHindmarch, lA comparison of the efficacy, tolerance and residual effects of zopiclone, flunitrazepam and placebo in insomniac outpatients. Int Clin Psychopharmacol 1990; 5(suppl 2):69–77Google Scholar
Ray, WAGriffin, MRSchaffner, WBaugh, DKMelton, LJPsychotropic drug use and the risk of hip fracture. N Engl J Med 1987; 316: 363–9Google ScholarPubMed
Rettig, HCde Haan, PZuurmond, WAvan Leeuwen, LEffects of hypnotics on sleep and psychomotor performance: a double-blind randomized study of lormetazepam, midazolam and zopiclone. Aneasthesia 1990; 45: 1079–82Google ScholarPubMed
Saano, VHansen, PPParonen, PInteractions and comparative effects of zopiclone, diazepam and lorazepam on psychomotor performance and elimination pharmacokinetics in healthy volunteers. Pnarmacol Toxicol 1992; 70: 135–9CrossRefGoogle ScholarPubMed
Seppälä, TNuotto, EDreyfus, JFDrug-alcohol interactions on psychomotor skills: zopiclone and flunitrazepam. Int Psychopharmacol 1987; 17(suppl 2):127–35Google Scholar
Tafti, MBesset, ABilliard, MEffects of zopiclone on subjective evaluation of sleep and daytime alertness and on psychomotor and physical performance tests in athletes. Prog Neuro-Psychopharmacol Biol Psychiat 1992; 16: 55–63CrossRefGoogle ScholarPubMed
Volkerts, ERO'Hanlon, JFResidual effects on real car driving performance: zopiclone versus flunitrazepam and nitrazepam (Dutch with English summary and legends). JDR J Drug Ther Res 1988; 13: 111–4Google Scholar
Warot, DBensimon, GDanjou, PPuech, AJComparative effects of zopiclone, triazolam and placebo on memory and psychomotor performance in healthy volunteers. Fundam Clin Pharmacol 1987; 1: 145–52CrossRefGoogle ScholarPubMed
Wickstrøm, EGotlibsen, OBBredesen, JEJensen, MHPerformance and mood following partial sleep deprivation: a randomized, double-blind, cross-over study of zopiclone, triazolam, flunitrazepam, ethanol and placebo. Hum Psychopharmacol 1988; 3: 3–11CrossRefGoogle Scholar
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