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Age at menarche is related to number of previous depressive episodes in patients with bipolar disorder

Published online by Cambridge University Press:  23 March 2020

B. Dunjic-Kostic ,
M. Pantovic Stefanovic ,
M. Lackovic ,
A. Damjanovic ,
A. Jovanovic ,
S. Totic-Poznanovic  and
M. Ivkovic
B. Dunjic-Kostic
Affiliation:
Clinic for Psychiatry Clinical Centre of Serbia, Department for Affective Disorders, Belgrade, Serbia University of Belgrade, School of Medicine, Belgrade, Serbia
M. Pantovic Stefanovic*
Affiliation:
Clinic for Psychiatry Clinical Centre of Serbia, Department for Affective Disorders, Belgrade, Serbia
M. Lackovic
Affiliation:
Clinic for Psychiatry Clinical Centre of Serbia, Department for Affective Disorders, Belgrade, Serbia University of Belgrade, School of Medicine, Belgrade, Serbia
A. Damjanovic
Affiliation:
Clinic for Psychiatry Clinical Centre of Serbia, Department for Affective Disorders, Belgrade, Serbia University of Belgrade, School of Medicine, Belgrade, Serbia
A. Jovanovic
Affiliation:
Clinic for Psychiatry Clinical Centre of Serbia, Department for Affective Disorders, Belgrade, Serbia University of Belgrade, School of Medicine, Belgrade, Serbia
S. Totic-Poznanovic
Affiliation:
Clinic for Psychiatry Clinical Centre of Serbia, Department for Affective Disorders, Belgrade, Serbia University of Belgrade, School of Medicine, Belgrade, Serbia
M. Ivkovic
Affiliation:
Clinic for Psychiatry Clinical Centre of Serbia, Department for Affective Disorders, Belgrade, Serbia University of Belgrade, School of Medicine, Belgrade, Serbia
*
* Corresponding author.

Abstract

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Introduction

Oestrogen fluctuations may be an important factor in the etiology of bipolar disorder and age at menarche is associated with the clinical course of BD. Moreover, it is associated with traits related to mood.

Aims

The aim of our study was to explore the differences in age at menarche between euthymic BD patients and healthy controls, as well as to explore the relationship between age at menarche and lifetime psychopathology within BD.

Methods

The study group consisted of 83 patients diagnosed with BD, compared to the healthy control group (n = 73) and matched according to age, gender, and body mass index (BMI). Lifetime psychopathology has been assessed according to predominant polarity as well as previous history of suicide attempts and psychotic episodes.

Results

Age at menarche in BD patients was similar to that in controls. After covarying for confounders, we observed that age at menarche is negatively related to number of previous depressive episodes in euthymic BD patients, but not other indicators of lifetime psychopathology.

Conclusions

BD patients with earlier age at menarche are more likely to present with more depressive episodes in the course of illness. Systemic, longitudinal monitoring of the course of illness, and potential hormonal fluctuations within particular groups of patients are warranted.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EV195
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S338
Copyright
Copyright © European Psychiatric Association 2016
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