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Age at onset in bipolar disorder: Investigation of the role of TaqIA polymorphism of DRD2 gene in a Sardinian sample

Published online by Cambridge University Press:  16 April 2020

A. Squassina ,
M. Manchia ,
M. Costa ,
C. Chillotti ,
R. Ardau ,
M. Del Zompo  and
G. Severino
A. Squassina*
Affiliation:
Laboratory of Molecular Genetics, Section of Clinical Pharmacology, Department of Neuroscience “B.B. Brodie”, University of Cagliari, Sp 8, Sestu-Monserrato, Km 0.700 Cagliari, Italy
M. Manchia
Affiliation:
Laboratory of Molecular Genetics, Section of Clinical Pharmacology, Department of Neuroscience “B.B. Brodie”, University of Cagliari, Sp 8, Sestu-Monserrato, Km 0.700 Cagliari, Italy Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
M. Costa
Affiliation:
Laboratory of Molecular Genetics, Section of Clinical Pharmacology, Department of Neuroscience “B.B. Brodie”, University of Cagliari, Sp 8, Sestu-Monserrato, Km 0.700 Cagliari, Italy
C. Chillotti
Affiliation:
Unit of Clinical Pharmacology, University Hospital of Cagliari, Cagliari, Italy
R. Ardau
Affiliation:
Unit of Clinical Pharmacology, University Hospital of Cagliari, Cagliari, Italy
M. Del Zompo
Affiliation:
Laboratory of Molecular Genetics, Section of Clinical Pharmacology, Department of Neuroscience “B.B. Brodie”, University of Cagliari, Sp 8, Sestu-Monserrato, Km 0.700 Cagliari, Italy Unit of Clinical Pharmacology, University Hospital of Cagliari, Cagliari, Italy
G. Severino
Affiliation:
Laboratory of Molecular Genetics, Section of Clinical Pharmacology, Department of Neuroscience “B.B. Brodie”, University of Cagliari, Sp 8, Sestu-Monserrato, Km 0.700 Cagliari, Italy
*
*Corresponding author. Tel.: +39 070 675 4334; fax: +39 070 675 4320. E-mail address: squassina@unica.it (A. Squassina).
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Abstract

Bipolar disorder (BD) is a highly heterogeneous and heritable psychiatric illness. Age at onset has been shown to be a powerful tool for dissecting both the phenotypic and genetic complexity of BD. In this article, we present findings from an association study between the DRD2 TaqIA polymorphism and age at onset, showing that both alleles and genotypes at this locus associate with early onset BD.

Keywords

Bipolar disorderAge at onsetDRD2TaqIAAdmixture analysis
Type
Short communication
Information
European Psychiatry , Volume 26 , Issue 3 , April 2011 , pp. 141 - 143
Copyright
Copyright © Elsevier Masson SAS 2011

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Footnotes

1

Contributed equally to the manuscript.

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