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An association study between polymorphisms in five genes in glutamate and GABA pathway and paranoid schizophrenia

Published online by Cambridge University Press:  16 April 2020

Boyu Zhang ,
Yanbo Yuan ,
Yanbin Jia ,
Xin Yu ,
Qi Xu ,
Yucun Shen  and
Yan Shen
Boyu Zhang
Affiliation:
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5, Dong Dan San Tiao, Beijing100005, China National Center of Human Genome Research, Beijing100176, China
Yanbo Yuan
Affiliation:
Peking University Institute of Mental Health, Beijing100083, China
Yanbin Jia
Affiliation:
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5, Dong Dan San Tiao, Beijing100005, China National Center of Human Genome Research, Beijing100176, China
Xin Yu
Affiliation:
Peking University Institute of Mental Health, Beijing100083, China
Qi Xu
Affiliation:
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5, Dong Dan San Tiao, Beijing100005, China National Center of Human Genome Research, Beijing100176, China
Yucun Shen
Affiliation:
Peking University Institute of Mental Health, Beijing100083, China
Yan Shen*
Affiliation:
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5, Dong Dan San Tiao, Beijing100005, China National Center of Human Genome Research, Beijing100176, China
*
*Corresponding author. E-mail address: sheny@ms.imicams.ac.cn (Y. Shen).
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Abstract

Dysfunctions of glutamatergic and GABAergic neurotransmission are two important hypotheses for the pathogenesis of schizophrenia. Thus, genes in the pathway are candidates for schizophrenia susceptibility. Phosphate-activated glutaminase (GLS), glutamine synthetase (GLUL), glutamic acid decarboxylase (GAD), GABA transaminase (ABAT) and succinic semialdehyde dehydrogenase (ALDH5A1) are five primary enzymes in glutamate and GABA synthetic and degradative pathway. In order to investigate the possible involvement of these genes in the development of paranoid schizophrenia, we genotyped 80 paranoid schizophrenics from northern China and 108 matched controls by polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLP) methods or directly sequencing of PCR product. Seven SNPs were found to be polymorphic in the population investigated. No significant differences in the genotype distributions or allele frequencies between patients and controls were found. Therefore, we conclude the polymorphisms studied in the five genes do not play major roles in pathogenesis of paranoid schizophrenia in the population investigated.

Keywords

SchizophreniaAssociation studyGLSGLULGADABATALDH5A1
Type
Original article
Information
European Psychiatry , Volume 20 , Issue 1 , January 2005 , pp. 45 - 49
Copyright
Copyright © Elsevier SAS 2005

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