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Assessing the infrequent oral supplementation of olanzapine long-acting injection in the treatment of schizophrenia

Published online by Cambridge University Press:  16 April 2020

H. Ascher-Svanum ,
X. Peng ,
W. Montgomery ,
D.E. Faries ,
A.H. Lawson ,
M.M. Witte ,
D. Novick ,
N. Jemiai ,
E. Perrin  and
D.P. McDonnell
H. Ascher-Svanum*
Affiliation:
Lilly Corporate Center, DC 4133, Eli Lilly and Company, Indianapolis, IN 46285, USA
X. Peng
Affiliation:
Lilly Corporate Center, DC 4133, Eli Lilly and Company, Indianapolis, IN 46285, USA
W. Montgomery
Affiliation:
Eli Lilly Australia Pty Ltd, 112, Wharf Road, West Ryde NSW 2114, Australia
D.E. Faries
Affiliation:
Eli Lilly and Company, Lilly Corporate Center, Drop Code 5024, Indianapolis, IN 46285, USA
A.H. Lawson
Affiliation:
Lilly Corporate Center, DC 4133, Eli Lilly and Company, Indianapolis, IN 46285, USA
M.M. Witte
Affiliation:
Lilly USA, LLC, Lilly Corporate Center, DC 4133, Indianapolis, IN 46285, USA
D. Novick
Affiliation:
Eli Lilly and Company Limited, Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, GU20 6PH, United Kingdom
N. Jemiai
Affiliation:
Eli Lilly and Company Limited, Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, GU20 6PH, United Kingdom
E. Perrin
Affiliation:
Eli Lilly and Company Limited, 13, rue Pagès, 92158 Suresnes cedex France
D.P. McDonnell
Affiliation:
Eli Lilly and Company Limited, Cork ELCL, DC 6158, United Kingdom
*
*Corresponding author. Tel.: +317-277-8713; Fax: +317-276-7100. E-mail address: haya@lilly.com (H. Ascher-Svanum).
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Abstract

Objective

Adding another antipsychotic to a treatment regimen was previously used in evaluating the medication's efficacy. Supplementation of depot antipsychotics with oral antipsychotics is particularly meaningful because depot formulations are typically chosen for patients struggling with adherence to oral antipsychotics. This post-hoc analysis assessed supplementation of olanzapine long-acting injection (olanzapine-LAI) with oral olanzapine.

Subjects and methods

We used 12 months of data from an open-label, single-arm extension study of patients with schizophrenia or schizoaffective disorder (N = 931) treated with olanzapine-LAI. The prevalence, duration, time to first supplementation, and best predictors of oral supplementation were assessed.

Results

Oral supplementation occurred in 21% of patients for a median of 31 days with mean modal dose of 10.8 mg/day. Mean time to first supplementation was shorter for patients who were at least moderately ill at baseline compared to less ill patients (47 vs. 97 days, p < 0.001). Best predictors of oral supplementation included a more severe illness profile at baseline, lower olanzapine-LAI dose prior to oral supplementation, supervised living arrangements, and being African-American.

Conclusion

Supplementation of olanzapine-LAI appears to be infrequent, of relatively short duration, and reserved for more severely ill patients who may require a targeted rescue medication due to signs of impending relapse.

Keywords

SchizophreniaOlanzapine long-acting injectionOral supplementation
Type
Original article
Information
European Psychiatry , Volume 26 , Issue 5 , August 2011 , pp. 313 - 319
Copyright
Copyright © Elsevier Masson SAS 2011

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