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Association of behavioral “Theory of Mind” Test performance with neurophysiological and vegetative parameters in schizophrenia patients and healthy subjects

Published online by Cambridge University Press:  23 March 2020

Z. Garakh ,
Y. Zaytseva ,
A. Morozova  and
V. Strelets
Z. Garakh
Affiliation:
Institute of Higher Nervous Activity and Neurophysiology of RAS, Psychophysiology, Moscow, Russia
Y. Zaytseva
Affiliation:
National Institute of Mental Health, Klecany, Czech Republic, Applied Neuroscience and Brain Imaging, Prague, Czech Republic Charles University in Prague, Prague, Czech Republic
A. Morozova
Affiliation:
Charles University in Prague, Prague, Czech Republic
V. Strelets
Affiliation:
Institute of Higher Nervous Activity and Neurophysiology of RAS, Psychophysiology, Moscow, Russia

Abstract

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Introduction

Theory of Mind (ToM) deficit is investigated by psychological and neurobiological methods using a range of social cognitive tests, including the verbal test Hinting Task. However, it remains unclear whether there is a connection between ToM results and the physiological characteristics in norm and in pathology.

Objectives

We performed the comparison of Hinting Task performance in patients with schizophrenia and healthy subjects; analysis of correlations between Hinting Task performance with physiological parameters; discriminant analysis in order to classify subject groups according to predictors, including psychological and physiological parameters.

Methods

We measured Hinting Task, spectral power of the EEG mu-rhythm (SP) and heart rate (HR) at rest and during a motion imagery task in 114 right-handed subjects, 1st episode patients with schizophrenia (SCH1) n = 29, chronically ill patients with schizophrenia, duration of illness more than 5 years, (SCH2) n = 23, and healthy subjects (НС) n = 62.

Results

Hinting Task rate: HC > SCH2 (P < 0.01), HC ≥ SCH1 (P = 0.07), SCH1 = SCH2 (P = 0.3). Only SCH1 Hinting Task score was associated with a complex of physiological parameters in the resting state [Multiple R = 0.78, F (3.25) = 13.31, P < 0.0001]. Discriminant function analysis of HC and the combined SCH group [F (7.106) = 7.078, P < 0.0000]. The samples were classified at 89% and 71%, respectively, including HR (P < 0.000001), SP in the resting state in C4 (P < 0.001), C3 (P < 0.01), SP changes in C3 (P < 0.05) and Hinting Task (P = 0.2).

Conclusions

Hinting Task Hinting Task is a part of classification model of norm and schizophrenia. Patients with first episode and chronically ill patients with schizophrenia do not differ in the studied parameters.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Viewing: Psychophysiology
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S766 - S767
Copyright
Copyright © European Psychiatric Association 2017
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