Hostname: page-component-78c5997874-ndw9j Total loading time: 0 Render date: 2024-11-10T07:38:06.621Z Has data issue: false hasContentIssue false
  • English
  • Français

Association of the intronic rs2072621 polymorphism of the X-linked GPR50 gene with affective disorder with seasonal pattern

Published online by Cambridge University Press:  15 April 2020

M. Delavest ,
C. Even ,
N. Benjemaa ,
M.-F. Poirier ,
R. Jockers  and
M.-O. Krebs
M. Delavest
Affiliation:
Inserm U894, laboratoire de physiopathologie des maladies psychiatriques, faculté de médecine Paris Descartes, université Paris Descartes, France
C. Even*
Affiliation:
Inserm U894, laboratoire de physiopathologie des maladies psychiatriques, faculté de médecine Paris Descartes, université Paris Descartes, France Clinique des maladies mentales et de l’encéphale, centre hospitalier Sainte-Anne, 100, rue de la Santé, 75014Paris, France
N. Benjemaa
Affiliation:
Inserm U894, laboratoire de physiopathologie des maladies psychiatriques, faculté de médecine Paris Descartes, université Paris Descartes, France Service hospitalo-universitaire, centre hospitalier Sainte-Anne, 7, rue Cabanis, 75014Paris, France
M.-F. Poirier
Affiliation:
Inserm U894, laboratoire de physiopathologie des maladies psychiatriques, faculté de médecine Paris Descartes, université Paris Descartes, France Service hospitalo-universitaire, centre hospitalier Sainte-Anne, 7, rue Cabanis, 75014Paris, France
R. Jockers
Affiliation:
CNRS (UMR 8104), Inserm U567, université Paris Descartes, institut Cochin, 22, rue Méchain, 75014Paris, France
M.-O. Krebs
Affiliation:
Inserm U894, laboratoire de physiopathologie des maladies psychiatriques, faculté de médecine Paris Descartes, université Paris Descartes, France Service hospitalo-universitaire, centre hospitalier Sainte-Anne, 7, rue Cabanis, 75014Paris, France
*
*Corresponding author. Tel.: +33 1 45 65 83 71; fax: +33 1 45 65 89 43. E-mail address: c.even@ch-sainte-anne.fr (C. Even).
Get access

Abstract

This case-control study found an association between Seasonal Affective Disorder (SAD) and a single nucleotide polymorphism (intronic rs2072621) of the gene encoding GPR50 (an orphan member of the G protein-coupled melatonin receptor subfamily) in females. This may represent a gender-specific risk factor and a molecular link between melatonin and SAD.

Keywords

Seasonal Affective DisordersMood disordersGenetics
Type
Short communications
Information
European Psychiatry , Volume 27 , Issue 5 , July 2012 , pp. 369 - 371
Copyright
Copyright © Elsevier Masson SAS 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Allen, J.M., Lam, R.W., Remick, R.A., Sadovnick, A.D.Depressive symptoms and family history in seasonal and nonseasonal mood disorders. Am J Psychiatry. 150 3: 1993 443–448.Google ScholarPubMed
Barrett, P., Ivanova, E., Graham, E.S., Ross, A.W., Wilson, D., Ple, H.et al.Photoperiodic regulation of cellular retinol binding protein, CRBP1 [corrected] and nestin in tanycytes of the third ventricle ependymal layer of the Siberian hamster. J Endocrinol. 191 3: 2006 687–698.CrossRefGoogle ScholarPubMed
Bhattacharyya, S., Luan, J., Challis, B., Keogh, J., Montague, C., Brennand, J.et al.Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels. J Lipid Res. 47 4: 2006 761–766.10.1194/jlr.M500338-JLR200CrossRefGoogle ScholarPubMed
Bocchetta, A., Piccardi, M.P., Martinelli, V., Quesada, G., Del Zompo, M.Maternal inheritance of manic depression in hemizygotes for the G6PD-Mediterranean mutation. Indirect evidence for Xq28 transmission in Sardinia. Psychiatr Genet. 9 2: 1999 63–68.CrossRefGoogle ScholarPubMed
Daniels, B.A., Kirkby, K.C., Mitchell, P., Hay, D., Mowry, B.Seasonal variation in hospital admission for bipolar disorder, depression and schizophrenia in Tasmania. Acta Psychiatr Scand. 102 1: 2000 38–43.10.1034/j.1600-0447.2000.102001038.xCrossRefGoogle ScholarPubMed
Doorack, J.E., Allen, J., Battaglia, J.Co-occurring SAD symptomatology and schizophrenia at high latitude: a pilot study. Int J Circumpolar Health. 66 3: 2007 248–256.10.3402/ijch.v66i3.18262CrossRefGoogle ScholarPubMed
Enoch, M.A., Goldman, D., Barnett, R., Sher, L., Mazzanti, C.M., Rosenthal, N.E.Association between seasonal affective disorder and the 5-HT2A promoter polymorphism - 1438G/A. Mol Psychiatry. 4 1: 1999 89–92.CrossRefGoogle Scholar
Faedda, G.L., Tondo, L., Teicher, M.H., Baldessarini, R.J., Gelbard, H.A., Floris, G.F.Seasonal mood disorders. Patterns of seasonal recurrence in mania and depression. Arch Gen Psychiatry. 50 1: 1993 17–23.CrossRefGoogle ScholarPubMed
Goikolea, J.M., Colom, F., Martinez-Aran, A., Sanchez-Moreno, J., Giordano, A., Bulbena, A.et al.Clinical and prognostic implications of seasonal pattern in bipolar disorder: a 10-year follow-up of 302 patients. Psychol Med. 37 11: 2007 1595–1599.10.1017/S0033291707000864CrossRefGoogle ScholarPubMed
Ivanova, E.A., Bechtold, D.A., Dupre, S.M., Brennand, J., Barrett, P., Luckman, S.M.et al.Altered metabolism in the melatonin-related receptor (GPR50) knockout mouse. Am J Physiol Endocrinol Metab. 294 1: 2008 E176–E182.10.1152/ajpendo.00199.2007CrossRefGoogle ScholarPubMed
Jang, K.L., Lam, R.W., Livesley, W.J., Vernon, P.A.Gender differences in the heritability of seasonal mood change. Psychiatry Res. 70 3: 1997 145–154.10.1016/S0165-1781(97)00030-9CrossRefGoogle ScholarPubMed
Jockers, R., Maurice, P., Boutin, J.A., Delagrange, P.Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?. Br J Pharmacol. 154 6: 2008 1182–1195.10.1038/bjp.2008.184CrossRefGoogle ScholarPubMed
Kishi, T., Kitajima, T., Ikeda, M., Yamanouchi, Y., Kinoshita, Y., Kawashima, K.et al.Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population. Eur Arch Psychiatry Clin Neurosci. 259 5: 2009 293–297.CrossRefGoogle ScholarPubMed
Lam, R.W., Levitan, R.D.Pathophysiology of seasonal affective disorder: a review. J Psychiatry Neurosci. 25 5: 2000 469–480.Google ScholarPubMed
Lee, T.M., Chan, C.C.Vulnerability by sex to seasonal affective disorder. Percept Mot Skills. 87 3 Pt 1 1998 1120–1122.CrossRefGoogle ScholarPubMed
Levitt, A.J., Boyle, M.H., Joffe, R.T., Baumal, Z.Estimated prevalence of the seasonal subtype of major depression in a Canadian community sample. Can J Psychiatry. 45 7: 2000 650–654.CrossRefGoogle Scholar
Levoye, A., Dam, J., Ayoub, M.A., Guillaume, J.L., Couturier, C., Delagrange, P.et al.The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. EMBO J. 25 13: 2006 3012–3023.CrossRefGoogle ScholarPubMed
Macintyre, D.J., McGhee, K.A., Maclean, A.W., Afzal, M., Briffa, K., Henry, B.et al.Association of GPR50, an X-linked orphan G protein-coupled receptor, and affective disorder in an independent sample of the Scottish population. Neurosci Lett. 475 3: 2010 169–173.CrossRefGoogle Scholar
Madden, P.A., Heath, A.C., Rosenthal, N.E., Martin, N.G.Seasonal changes in mood and behavior. The role of genetic factors. Arch Gen Psychiatry. 53 1: 1996 47–55.CrossRefGoogle ScholarPubMed
Magnusson, A., Partonen, T.The diagnosis, symptomatology, and epidemiology of seasonal affective disorder. CNS Spectr. 10 8: 2005 625–634.CrossRefGoogle ScholarPubMed
Mansour, H.A., Wood, J., Logue, T., Chowdari, K.V., Dayal, M., Kupfer, D.J.et al.Association study of eight circadian genes with bipolar I disorder, schizo-affective disorder and schizophrenia. Genes Brain Behav. 5 2: 2006 150–157.10.1111/j.1601-183X.2005.00147.xCrossRefGoogle Scholar
Massat, I., Souery, D., Del-Favero, J., Oruc, L., Noethen, M.M., Blackwood, D.et al.Excess of allele1 for alpha3 subunit GABA receptor gene (GABRA3) in bipolar patients: a multicentric association study. Mol Psychiatry. 7 2: 2002 201–207.CrossRefGoogle ScholarPubMed
Partonen, T., Treutlein, J., Alpman, A., Frank, J., Johansson, C., Depner, M.et al.Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression. Ann Med. 39 3: 2007 229–238.10.1080/07853890701278795CrossRefGoogle ScholarPubMed
Roecklein, K.A., Rohan, K.J., Duncan, W.C., Rollag, M.D., Rosenthal, N.E., Lipsky, R.H.et al.A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder. J Affect Disord. 114 1–3: 2009 279–285.CrossRefGoogle ScholarPubMed
Rosenthal, N.E., Sack, D.A., Gillin, J.C., Lewy, A.J., Goodwin, F.K., Davenport, Y.et al.Seasonal affective disorder. A description of the syndrome and preliminary findings with light therapy. Arch Gen Psychiatry. 41 1: 1984 72–80.CrossRefGoogle ScholarPubMed
Rosenthal, N.E., Mazzanti, C.M., Barnett, R.L., Hardin, T.A., Turner, E.H., Lam, G.K.et al.Role of serotonin transporter promoter repeat length polymorphism (5-HTTLPR) in seasonality and seasonal affective disorder. Mol Psychiatry. 3 2: 1998 175–177.CrossRefGoogle ScholarPubMed
Schaffer, A., Levitt, A.J., Boyle, M.Influence of season and latitude in a community sample of subjects with bipolar disorder. Can J Psychiatry. 48 4: 2003 277–280.CrossRefGoogle Scholar
Sidibe, A., Mullier, A., Chen, P., Baroncini, M., Boutin, J.A., Delagrange, P.et al.Expression of the orphan GPR50 protein in rodent and human dorsomedial hypothalamus, tanycytes and median eminence. J Pineal Res. 48 3: 2010 263–269.CrossRefGoogle ScholarPubMed
Thomson, P.A., Wray, N.R., Thomson, A.M., Dunbar, D.R., Grassie, M.A., Condie, A.et al.Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor. Mol Psychiatry. 10 5: 2005 470–478.CrossRefGoogle ScholarPubMed
Westrin, A., Lam, R.W.Seasonal affective disorder: a clinical update. Ann Clin Psychiatry. 19 4: 2007 239–246.CrossRefGoogle ScholarPubMed
Wigg, K., Feng, Y., Gomez, L., Kiss, E., Kapornai, K., Tamas, Z.et al.Genome scan in sibling pairs with juvenile-onset mood disorders: Evidence for linkage to 13q and Xq. Am J Med Genet B Neuropsychiatr Genet. 150B 5: 2009 638–646.CrossRefGoogle ScholarPubMed
Zhang, J., Liao, G., Liu, C., Sun, L., Liu, Y., Wang, Y.et al.The association of CLOCK gene T3111C polymorphism and hPER3 gene 54-nucleotide repeat polymorphism with Chinese Han people schizophrenics. T. Mol Biol Rep. 2010; 38: 349–354.10.1007/s11033-010-0114-2CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.