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Autoantibody profiles are associated with specific clinical features in psychotic disorders

Published online by Cambridge University Press:  13 August 2021

K.O. Schubert ,
A. Jernbom Falk ,
C. Galletly ,
D. Just ,
C. Toben ,
B. Baune ,
S. Clark ,
D. Liu ,
P. Nilsson  and
A. Manberg
K.O. Schubert*
Affiliation:
Discipline Of Psychiatry, The University of Adelaide, Adelaide, Australia Community Mental Health, Northern Adelaide Mental Health Services, Salisbury, Australia
A. Jernbom Falk
Affiliation:
Science For Life Laboratory, Royal Institute of Technology, Stockholm, Sweden
C. Galletly
Affiliation:
Discipline Of Psychiatry, The University of Adelaide, Adelaide, Australia Community Mental Health, Northern Adelaide Mental Health Services, Salisbury, Australia
D. Just
Affiliation:
Science For Life Laboratory, Royal Institute of Technology, Stockholm, Sweden
C. Toben
Affiliation:
Discipline Of Psychiatry, The University of Adelaide, Adelaide, Australia
B. Baune
Affiliation:
The University Of Melbourne, The Florey Institute of Neuroscience and Mental Health, Parkville, Australia Department Of Psychiatry And Psychotherapy, University of Münster, Münster, Germany
S. Clark
Affiliation:
Discipline Of Psychiatry, The University of Adelaide, Adelaide, Australia
D. Liu
Affiliation:
Discipline Of Psychiatry, The University of Adelaide, Adelaide, Australia
P. Nilsson
Affiliation:
Science For Life Laboratory, Royal Institute of Technology, Stockholm, Sweden
A. Manberg
Affiliation:
Science For Life Laboratory, Royal Institute of Technology, Stockholm, Sweden
*
*Corresponding author.

Abstract

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Introduction

Immune system abnormalities exist across a range of psychiatric disorders. Autoimmunity, characterized by the production of antibodies against the body’s own antigens, is a feature of immune system dysfunction and could play a role in mental disorder pathophysiology. Better understanding of the associations of auto-immunoglobulin G (IgG) repertoires with clinical features of mental illness could yield novel models of psychosis pathophysiology and markers for biological patient stratification.

Objectives

To undertake global screening for auto-IgG expression in a large cohort of people with psychotic disorders; to determine whether associations exist between autoantibody expression and clinical features.

Methods

Cross-sectional quantification of auto-IgGs in blood plasma of 461 people with established psychotic disorder diagnoses. For global screening, pooled samples of phenotypically representative patient groups were exposed to planar protein microarrays containing 42,000 human antigens. For targeted profiling, expression levels of 380 autoantibodies were quantified by suspension bead array (SBA) in each patient’s plasma.

Results

We identified highly individual autoantibody profiles with no evidence for co-expression patterns. We found 6 autoantibodies robustly associated with specific psychopathology: anti-AP3B2, detected in 5% of the cohort of whom 100% had persecutory delusions; anti-TDO2 (5% of the cohort, 100% hallucinations); anti-CRYGN (4%, 86% initial insomnia); anti-APMAP (3%, 86% poor appetite); anti-OLFM1 (2.5%, 100% above median cognitive function); and anti-WHAMMP3 (2%, 90% anhedonia and dysphoria). Examination of the auto-IgG binding site on the TDO2 protein revealed a putative pathophysiological mechanism involving the kynurenine pathway.

Conclusions

We identified 6 frequently occurring autoantibodies that were associated with specific clinical features in people with psychotic disorders.

Disclosure

No significant relationships.

Keywords

AutoimmunityAutoantibodiespsychopathologypsychosis
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S675 - S676
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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