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Bipolar disorder and peripartum mood episodes: Epidemiology and clinical correlates

Published online by Cambridge University Press:  13 August 2021

E. Aragno ,
G. Di Salvo ,
G. Rosso  and
G. Maina
E. Aragno*
Affiliation:
Department Of Neurosciences “rita Levi Montalcini”, University of Turin, torino, Italy
G. Di Salvo
Affiliation:
Department Of Neurosciences Rita Levi Montalcini, University of Turin, Turin, Italy
G. Rosso
Affiliation:
Department Of Neurosciences Rita Levi Montalcini, University of Turin, Turin, Italy
G. Maina
Affiliation:
Department Of Neurosciences “rita Levi Montalcini”, University of Turin, torino, Italy
*
*Corresponding author.

Abstract

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Introduction

It is known that the peripartum period is a high-risk period of recurrence in bipolar disorder (BD). However, data on correlations between reproductive life events, such as age at menarche and peripartum period, are mixed in BD.

Objectives

The aims of this retrospective study are to investigate the lifetime rate of peripartum mood episodes, the clinical correlates and the relationship between age at menarche and peripartum episode in a sample of women with BD.

Methods

The study focused on comparisons between women with vs. without peripartum mood episodes (n = 292). Socio-demographic and clinical characteristics between women with vs without BD peripartum episode were examined through descriptive statistics.Adjusted logistic regression analysis was run to examine the association between variables.

Results

In our sample, 30% had at least one BD peripartum episode. Women with peripartum episode had significantly earlier age at menarche, earlier onset of BD and longer duration of untreated disorder compared to women without peripartum episode. After adjustment, the late menarche (>15 years) was associated with lower probability of BD episodes during the peripartum period compared to normal menarche (12-14 years).

Conclusions

Peripartum mood episodes are common in BD and are correlated with early onset of BD and long duration of untreated disorder. Moreover, age at menarche may be related to the risk of peripartum mood episodes. The results deserve to be deepened in further studies.

Keywords

bipolar disorderwomenreproductive cyclesperipartum episodes
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S197
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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