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Borna disease virus and psychiatry

Published online by Cambridge University Press:  16 April 2020

O. Taieb ,
J.M. Baleyte ,
P. Mazet  and
A.M. Fillet
O. Taieb
Affiliation:
Department of Virology, CERVI, 47-83 Boulevard de l’Hôpital, 75013Paris, France Department of Child and Adolescent Psychiatry, Groupe Hospitalier Pitié-Salpêtrière, 47-83 Boulevard de l’Hôpital, 75013Paris, France
J.M. Baleyte
Affiliation:
Department of Child and Adolescent Psychiatry, Groupe Hospitalier Pitié-Salpêtrière, 47-83 Boulevard de l’Hôpital, 75013Paris, France
P. Mazet
Affiliation:
Department of Child and Adolescent Psychiatry, Groupe Hospitalier Pitié-Salpêtrière, 47-83 Boulevard de l’Hôpital, 75013Paris, France
A.M. Fillet*
Affiliation:
Department of Virology, CERVI, 47-83 Boulevard de l’Hôpital, 75013Paris, France
*
* Correspondence and reprints.
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Abstract

Borna disease virus (BDV), a noncytolytic neurotropic nonsegmented negative-stranded RNA virus with a wide geographic distribution, infects several vertebrate animal species and causes an immune-mediated central nervous system (CNS) disease with various manifestations, depending on both host and viral factors. In animal infections, BDV can persist in the CNS and induce alterations in brain cell functions, neurodevelopmental abnormalities and behavioral disturbances. An association between BDV and psychiatric disorders (essentially schizophrenia and affective disorders) has been suggested by some serologic and molecular studies but further investigations are required to substantiate the possible contribution of this virus to the pathogenesis of these disorders.

Type
Review
Information
European Psychiatry , Volume 16 , Issue 1 , February 2001 , pp. 3 - 10
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS.

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