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The brain in oral clefting: preliminary results of a systematic review with meta-analyses

Published online by Cambridge University Press:  01 September 2022

K.A. Sándor-Bajusz ,
A. Saadi ,
E. Varga ,
G. Csábi ,
G. Antonoglou  and
S. Lohner
K.A. Sándor-Bajusz*
Affiliation:
University of Pécs, Paediatrics, Pécs, Hungary
A. Saadi
Affiliation:
Borlänge Specialist Clinic, Region Dalarna, Adult Psychiatric Division, Borlänge, Sweden
E. Varga
Affiliation:
University of Pécs, Department Of Paediatrics, Pécs, Hungary
G. Csábi
Affiliation:
University of Pécs, Paediatrics, Pécs, Hungary
G. Antonoglou
Affiliation:
Medical University of Graz, Oral Surgery Department, Faculty Of Dentistry, Graz, Austria
S. Lohner
Affiliation:
University of Pécs, Paediatrics, Pécs, Hungary
*
*Corresponding author.

Abstract

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Introduction

Previous neuroimaging studies of individuals with nonsyndromic oral clefts have revealed subtle brain structural differences compared to matched controls. Additional studies strongly suggest that the higher incidence of neuropsychiatric issues observed in these individuals may be explained by these neuroanatomical differences. Currently there are no studies that have assessed the overall empirical evidence of the effect of oral clefts on the brain.

Objectives

Our aim was to summarize available evidence on potential brain structure differences in individuals with nonsyndromic oral clefts and their matched controls. In the current presentation, we discuss the results of regional brain structural differences.

Methods

Five databases were systematically searched in September 2020 for case-control studies that reported neuroimaging in healthy individuals and individuals with nonsyndromic oral clefts. Duplicate study selection, data extraction, random effects meta-analyses of mean differences (MDs) and their 95% confidence intervals were performed in order to compare regional brain MRI volumes.

Results

We have identified 245 records following the database searches, from which 12 records met the inclusion criteria. Quantitative data on brain structure were available in three studies.The cerebellum, occipital and temporal lobes were significantly smaller in the cleft group compared to controls (MD: -12.46, 95% CI: -18.26, -6.67, n=3 studies; MD:-7.39, 95% CI: -12.80, -1.99, n=2 studies; MD: -10.53, 95% CI: -18.23, -2.82, n=2 studies, respectively).

Conclusions

There may be structural brain differences between individuals with nonsyndromic oral clefts and their controls based on the available evidence.

Disclosure

No significant relationships.

Keywords

cleft lipcleft palateBrainNeuroimaging
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S641
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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