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Cavum septum pellucidum and adhesio interthalamica in schizophrenia: an MRI study

Published online by Cambridge University Press:  16 April 2020

José Alexandre de Souza Crippa ,
Antonio Waldo Zuardi ,
Geraldo F. Busatto ,
Rafael Faria Sanches ,
Antonio Carlos Santos ,
David Araújo ,
Edson Amaro ,
Jaime Eduardo Cecílio Hallak ,
Virginia Ng  and
Philip K. McGuire
José Alexandre de Souza Crippa*
Affiliation:
Department of Neuropsychiatry and Medical Psychology, Faculty of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil Department of Psychological Medicine, Institute de Psychiatry, Neuroimaging Section, University of London, London, UK
Antonio Waldo Zuardi
Affiliation:
Department of Neuropsychiatry and Medical Psychology, Faculty of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
Geraldo F. Busatto
Affiliation:
Department of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil
Rafael Faria Sanches
Affiliation:
Department of Neuropsychiatry and Medical Psychology, Faculty of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
Antonio Carlos Santos
Affiliation:
Department of Medical Clinic, Radiology Section, Faculty of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
David Araújo
Affiliation:
Department of Neuropsychiatry and Medical Psychology, Faculty of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
Edson Amaro
Affiliation:
Department of Psychological Medicine, Institute de Psychiatry, Neuroimaging Section, University of London, London, UK Department of Radiology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil
Jaime Eduardo Cecílio Hallak
Affiliation:
Department of Neuropsychiatry and Medical Psychology, Faculty of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
Virginia Ng
Affiliation:
Department of Psychological Medicine, Institute de Psychiatry, Neuroimaging Section, University of London, London, UK
Philip K. McGuire
Affiliation:
Department of Psychological Medicine, Institute de Psychiatry, Neuroimaging Section, University of London, London, UK
*
*Corresponding author. Tel.: +55 16 3602 2201; fax: +55 16 3602 2544. E-mail address: jcrippa@fmrp.usp.br (J.A.d.S. Crippa).
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Abstract

Several studies have independently suggested that patients with schizophrenia are more likely to have an enlarged cavum septum pellucidum (CSP) and an absent adhesio interthalamica (AI), respectively. However, neither finding has been consistently replicated and it is unclear whether there is an association between these two midline brain abnormalities. Thus, we compared the prevalence of absent AI and the prevalence, size and volume of CSP in 38 patients with schizophrenia and 38 healthy controls using magnetic resonance imaging (MRI). There were no between group differences in the presence or volume of CSP; however, an enlarged CSP was commoner among patients than controls. There was also a positive correlation between CSP ratings and volumes. No differences in the presence or absence of the AI were found between patients and controls; however, an absent AI was commoner in male patients with schizophrenia than females. There was absolutely no overlap between the presence of a large CSP and an absence of AI. In conclusion, our findings are in line with several case series and other MRI investigations that have shown a higher incidence of putatively developmental brain abnormalities in patients with schizophrenia, particularly in males, and support the neurodevelopmental model of this disorder.

Keywords

SchizophreniaCavum septum pellucidumAdhesio interthalamicaMRI
Type
Original articles
Information
European Psychiatry , Volume 21 , Issue 5 , July 2006 , pp. 291 - 299
Copyright
Copyright © Elsevier SAS 2006

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