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Characteristic brain hypoperfusion by 99mTc-ECD single photon emission computed tomography (SPECT) in patients with the first-episode schizophrenia

Published online by Cambridge University Press:  16 April 2020

R. Wake ,
T. Miyaoka ,
K. Kawakami ,
K. Tsuchie ,
T. Inagaki ,
J. Horiguchi ,
Y. Yamamoto ,
T. Hayashi  and
H. Kitagaki
R. Wake*
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1, Enyacho, Izumo693-8501, Japan
T. Miyaoka
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1, Enyacho, Izumo693-8501, Japan
K. Kawakami
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1, Enyacho, Izumo693-8501, Japan
K. Tsuchie
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1, Enyacho, Izumo693-8501, Japan
T. Inagaki
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1, Enyacho, Izumo693-8501, Japan
J. Horiguchi
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1, Enyacho, Izumo693-8501, Japan
Y. Yamamoto
Affiliation:
Department of Radiology, Shimane University School of Medicine Hospital, 89-1, Enyacho, Izumo693-8501, Japan
T. Hayashi
Affiliation:
Department of Radiology, Shimane University School of Medicine Hospital, 89-1, Enyacho, Izumo693-8501, Japan
H. Kitagaki
Affiliation:
Department of Radiology, Shimane University School of Medicine Hospital, 89-1, Enyacho, Izumo693-8501, Japan
*
*Corresponding author. Tel.: +81 853 20 2263; fax: +81 853 20 2260. E-mail address: rei@med.shimane-u.ac.jp (R. Wake).
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Abstract

Objective

In this study, we evaluated brain perfusion in patients with first-episode medicated schizophrenia using the new analytical method, statistical parametric mapping (SPM) applied to single photon emission computed tomography (SPECT).

Method

We performed SPECT with 99-Tc-ethyl cysteinate dimer (99mTc-ECD) of the brain and magnetic resonance imaging (MRI) in patients with schizophrenia (n = 30) and control subjects matched for age and gender (n = 37). A voxel-by-voxel group analysis was performed using SPM2 (Z > 3.0, P < 0.001, uncorrected for multiple comparisons).

Result

In comparison with control subjects, the volumes of the bilateral frontal areas were found to be decreased on MRI. Blood flow was found to be reduced in the bilateral temporal areas in the patients with schizophrenia on SPECT.

Conclusion

In this study, patients with first-episode schizophrenia appeared to have significant bilateral temporal hypoperfusion, although temporal volumes were not significantly decreased in comparison with control subjects. Abnormality of temporal lobe blood flow in schizophrenia may show that functional changes occur earlier than structural changes, and may assist in the diagnosis of schizophrenia.

Keywords

SchizophreniaNeuroimagingSPECT
Type
Brain Anatomy and Imaging
Information
European Psychiatry , Volume 25 , Issue 6 , October 2010 , pp. 361 - 365
Copyright
Copyright © Elsevier Masson SAS 2010

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