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Ciprofloxacin-induced acute psychosis in a patient with multidrug-resistant tuberculosis

Published online by Cambridge University Press:  16 April 2020

Christine Norra ,
Erik Skobel ,
Christian Breuer ,
Gerhard Haase ,
Peter Hanrath  and
Paul Hoff
Christine Norra*
Affiliation:
Department of Psychiatry and Psychotherapy, University Aachen, Pauwelsstrasse 30, Aachen52074, Germany
Erik Skobel
Affiliation:
Department of Internal Medicine, University Aachen, Pauwelsstrasse 30, Aachen52074, Germany
Christian Breuer
Affiliation:
Department of Internal Medicine, University Aachen, Pauwelsstrasse 30, Aachen52074, Germany
Gerhard Haase
Affiliation:
Institute of Medical Microbiology, University Aachen, Pauwelsstrasse 30, Aachen52074, Germany
Peter Hanrath
Affiliation:
Department of Internal Medicine, University Aachen, Pauwelsstrasse 30, Aachen52074, Germany
Paul Hoff
Affiliation:
Department of Psychiatry and Psychotherapy, University Aachen, Pauwelsstrasse 30, Aachen52074, Germany
*
2Corresponding author. cnorra@ukaachen.de
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Abstract

Tuberculosis (TB) increasingly appears in a multidrug-resistant form (MDR-TB) in Europe, too. Treatment remains difficult due to various side effects of the multi-drug-regimens. Ciprofloxacin is widely used as one of the few TB-second-line drugs. We report on the course of a ciprofloxacin-induced acute psychosis in a patient with MDR(isoniazid, streptomycin)-TB which resolved after cessation of ciprofloxacin treatment and introduction of a novel oxazolidone. Careful treatment considerations particularly in patients with additional predisposing factors to neuropsychiatric symptoms are recommended in the potentially dangerous MDR-TB, thus creating an enormous therapeutic challenge.

Keywords

Multidrug-resistant tuberculosisCiprofloxacinPsychosisOxazolidones
Type
Case report
Information
European Psychiatry , Volume 18 , Issue 5 , August 2003 , pp. 262 - 263
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2003

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