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The CLDN5 locus may be involved in the vulnerability to schizophrenia

Published online by Cambridge University Press:  16 April 2020

Z.-Y. Sun ,
J. Wei ,
L. Xie ,
Y. Shen ,
S.-Z. Liu ,
G.-Z. Ju ,
J.-P. Shi ,
Y.-Q. Yu ,
X. Zhang  and
Q. Xu
...Show all authors
Z.-Y. Sun
Affiliation:
Jilin University Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun130021, China
J. Wei*
Affiliation:
Schizophrenia Association of Great Britain, Institute of Biological Psychiatry, Bryn Hyfryd, The Crescent, Bangor, Gwynedd LL57 2AG, UK
L. Xie
Affiliation:
Jilin University Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun130021, China
Y. Shen
Affiliation:
The National Center for Genome Research (Beijing), Beijing 100176, China
S.-Z. Liu
Affiliation:
Jilin University Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun130021, China
G.-Z. Ju
Affiliation:
The National Center for Genome Research (Beijing), Beijing 100176, China
J.-P. Shi
Affiliation:
Jilin University Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun130021, China
Y.-Q. Yu
Affiliation:
Jilin University Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun130021, China
X. Zhang
Affiliation:
Jilin University Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun130021, China
Q. Xu*
Affiliation:
The National Center for Genome Research (Beijing), Beijing 100176, China
G.P. Hemmings
Affiliation:
Schizophrenia Association of Great Britain, Institute of Biological Psychiatry, Bryn Hyfryd, The Crescent, Bangor, Gwynedd LL57 2AG, UK
*
*Corresponding authors. Email address: jwei@sagb.co.uk (J.Wei); xuqi@pumc.edu.cn (Q. Xu).
*Corresponding authors. Email address: jwei@sagb.co.uk (J.Wei); xuqi@pumc.edu.cn (Q. Xu).
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Abstract

The present study was designed to detect three single nucleotide polymorphisms (SNPs) located on 22q11 that was thought as being of particularly importance for genetic research into schizophrenia. We recruited a total of 176 Chinese family trios of Han descent, consisting of mothers, fathers and affected offspring with schizophrenia for the genetic analysis. The transmission disequilibrium test (TDT) showed that of three SNPs, rs10314 in the 3′-untranslated region of the CLDN5 locus was associated with schizophrenia (χ2 = 4.75, P = 0.029). The other two SNPs, rs1548359 present in the CDC45L locus centromeric of rs10314 and rs739371 in the 5′-flanking region of the CLDN5 locus, did not show such an association. The global chi-square (χ2) test showed that the 3-SNP haplotype system was not associated with schizophrenia although the 1-df test for individual haplotypes showed that the rs1548359(C)-rs10314(G)-rs739371(C) haplotype was excessively non-transmitted (χ2 = 5.32, P = 0.02). Because the claudin proteins are a major component for barrier-forming tight junctions that could play a crucial role in response to changing natural, physiological and pathological conditions, the CLDN5 association with schizophrenia may be an important clue leading to look into a meeting point of genetic and environmental factors.

Keywords

CLDN5Del22q11 regionLinkage disequilibrium (LD)SchizophreniaSingle nucleotide polymorphisms (SNPs)
Type
Original article
Information
European Psychiatry , Volume 19 , Issue 6 , September 2004 , pp. 354 - 357
Copyright
Copyright © 2004 European Psychiatric Association

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