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A clinical trial with olanzapine in schizophrenia with allele variation of the DRD4 and maoa gene

Published online by Cambridge University Press:  16 April 2020

F.W. Lung  and
T.S. Cheng
F.W. Lung
Affiliation:
Department of Psychiatry, Military Kaohsiung General Hospital, Kaohsiung, Taiwan Graduate Institute of Behavior Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan Department of Psychiatry, National Defense Medical University, Taipei, Taiwan Calo Psychiatric Center, Pingtung County, Taiwan
T.S. Cheng
Affiliation:
Department of Psychiatry, Military Kaohsiung General Hospital, Kaohsiung, Taiwan

Abstract

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Objective:

The aim of this study was to explore the treatment effect of olanzapine in the polymorphisms of MAOA and DRD4 VNTRS in schizophrenia.

Method:

Over a 3-month period, 50 patients with schizophrenia were administered olanzapine (10–30mg). Treatment response was assessed by checking for improvement in psychotic symptoms as measured on the Positive and Negative Syndrome Scale Manual (PANSS Manual) and Brief Psychiatric Rating Scale (BPRS).

Results:

The long form of MAOA demonstrated a better drug response for positive symptoms, and the short form of MAOA demonstrated a better drug response for aggression. There was a negative correlation between DRD4 VNTRS and improvement in general psychopathology. Both female patients and those with a shorter duration of the illness had a better response to olanzapine.

Conclusion:

The results suggest polymorphisms of MAOA and the DRD4 gene, sex, and duration of illness may be useful response predictors in schizophrenia.

Keywords

olanzapineMAOA polymorphismDRD4 geneschizophrenia
Type
Poster Session 1: Schizophrenia and Other Psychosis
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S122 - S123
Copyright
Copyright © European Psychiatric Association 2007
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