Hostname: page-component-cd9895bd7-dzt6s Total loading time: 0 Render date: 2024-12-25T19:47:58.649Z Has data issue: false hasContentIssue false
  • English
  • Français

Clozapine effectiveness in a psychiatric service in Italy

Published online by Cambridge University Press:  16 April 2020

D Berardi ,
M Troia ,
M Dell'Atti ,
C Bartoletti ,
C Cantaroni  and
G Ferrari
D Berardi
Affiliation:
University of Bologna, Department of Psychiatry, ‘P Ottonello’, Viale C Pepoli, 5, 40123, Bologna
M Troia
Affiliation:
University of Bologna, Department of Psychiatry, ‘P Ottonello’, Viale C Pepoli, 5, 40123, Bologna
M Dell'Atti
Affiliation:
University of Bologna, Department of Psychiatry, ‘P Ottonello’, Viale C Pepoli, 5, 40123, Bologna
C Bartoletti
Affiliation:
Mental Health Service ‘Villa Olimpia’, AWL Bologna, Italy
C Cantaroni
Affiliation:
University of Bologna, Department of Psychiatry, ‘P Ottonello’, Viale C Pepoli, 5, 40123, Bologna
G Ferrari
Affiliation:
University of Bologna, Department of Psychiatry, ‘P Ottonello’, Viale C Pepoli, 5, 40123, Bologna
Get access

Summary

Clozapine was administered to 28 resistant schizophrenics at psychiatric services in Bologna. At 26 weeks 62% responded. Positive and negative symptoms improved, but decrease of negative symptoms partially depended upon improvement of positive and EPS. No cases of agranulocytosis were seen. Some drop-outs were related to difficulties with psychopathological improvement.

Keywords

clozapineeffectivenesspsychiatric servicesclinicalschizophreniatreatment-resistance
Type
Short communication
Information
European Psychiatry , Volume 13 , Issue 6 , September 1998 , pp. 317 - 319
Copyright
Copyright © Elsevier, Paris 1998

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Andreasen, NCThe scale for the assessment of negative symptoms (SANS) Iowa City: University of Iowa; 1983.Google Scholar
Andreasen, NCThe scale for the assessment of positive symptoms (SAPS) Iowa City: University of Iowa; 1984.Google Scholar
American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders ed. III Washington: American Psychiatric Association; 1987.Google Scholar
Baldessarini, RJFrankenburg, FRClozapine: a novel antipsychotic agent N Engl J Med 1991; 324: 746–754Google ScholarPubMed
Barnes, TREA rating scale for drug-induced akathisia Br J Psychiatry 1989; 154: 672–676CrossRefGoogle ScholarPubMed
Breier, ABuchanan, RWIrish, DCarpenter, WTClozapine treatment of outpatients with schizophrenia: outcome and long-term response patterns Hosp Comm Psychiatry 1993; 44: 1145–1149Google ScholarPubMed
Breier, ABuchanan, RWKirkpatrick, BDavis, OrIrish, DSummerfelt, ACarpenter, WTEffects of clozapine on positive and negative symptoms in outpatients with schizophrenia Am J Psychiatry 1994; 151: 20–26Google ScholarPubMed
Cohen, SChiles, JMcNaughton, AWeight gain associated with clozapine Am J Psychiatry 1990; 147: 503–504Google ScholarPubMed
Gordon, BJMilke, DJDose related response to clozapine in a state psychiatric hospital population: a naturalistic study Psychiatr Q 67suppl 11996 65–74CrossRefGoogle Scholar
Guy, WECDEU assessment manual for psychopharmacology Washington DC: US DHEW publishing number ADM 76-338 217-22 1976 283–286Google Scholar
Kane, JHonigfeld, GSinger, JMeltzer, HClozapine for the treatment resistant schizophrenic: A double-blind comparison with chlorpromazine Arch Gen Psychiatry 1988; 45: 789–796CrossRefGoogle ScholarPubMed
Kirkegaard, AHammershoj, EOstergard, PEvaluation of side effects due to clozapine in long-term treatment of psychosis Drug Resource 1982; 33: 465–468Google Scholar
Leadbetter, RShutty, MPavalonis, DVieweg, VHiggins, PDowns, MClozapine-induced weight gain: prevalence and clinical relevance Am J Psychiatry 1992; 149: 68–72Google ScholarPubMed
Lieberman, JASafferman, AZPollack, SSzymaski, SJohns, CHoward, Aet al.Clinical effects of clozapine in chronic schizophrenia: response to treatment and predictors of outcome Am J Psychiatry 1994; 151: 1744–1752Google ScholarPubMed
Meltzer, HYBastard, BYoung Kwon, KRamirez, LFBurnett, SSharpe, JA prospective study of clozapine in treatment-resistant schizophrenic patients Psychopharmacology 99suppl 11989 68–72CrossRefGoogle ScholarPubMed
Meltzer, HYBurnett, SBastani, BRamirez, LFEffects of six months of clozapine treatment on the quality of life of chronic schizophrenic patients Hosp Comm Psychiatry 1990; 41: 892–897Google ScholarPubMed
Meltzer, HYDimensions of outcome with clozapine Br J Psychiatry 160suppl 171992 46–53CrossRefGoogle Scholar
Miller, DPerry, PJCadoret, RJAndreasen, NCClozapine's effect on negative symptoms in treatment-refractory schizophrenics Compr Psychiatry 1994; 35: 8–15CrossRefGoogle ScholarPubMed
Pickar, DOwen, RRLitman, REKonicki, EGutierrez, RRapaport, MHClinical, biologic response to clozapine in patients with schizophrenia. Crossover comparison with fluphenazine Arch Gen Psychiatry 1992; 49: 345–353CrossRefGoogle ScholarPubMed
Overall, JEGorham, DRThe Brief Psychiatry Rating Scale Psychological Report 1962; 10: 799–812CrossRefGoogle Scholar
Povlsen, UGNoring, UFog, RGerlach, JTolerability and therapeutic effect of clozapine Acta Psychiatr Scand 1985; 71: 176–185CrossRefGoogle Scholar
Schooler, NRKane, JMResearch diagnosis for tardive diskinesia Arch Gen Psychiatry 1982; 39: 486–487Google Scholar
Simpson, GMAngus, JWSA Rating Scale for Extrapyramidal Side Effects Acta Psychiatr Scand 212suppl 441970 11–19CrossRefGoogle ScholarPubMed
Umbricht, DSGPollack, SKane, JMClozapine and weight gain J Clin Psychiatry 55suppl B1994 157–160Google ScholarPubMed
Urdain, APMestre, NPMestre, PPAguirre, JFPClozapine in the treatment of schizophrenia Euro J Psychiatry 1990; 4: 91–94Google Scholar
Verhoeven, WMDoesburg, WHSnoej, RRutgers, AJMPVandongen, PHMEfficacy of clozapine in treatment-resistant psychosis and neuroleptic sensitivity: results of Dutch open multicenter project Euro Psychiatry 1992; 7: 77–84CrossRefGoogle Scholar
Submit a response

Comments

No Comments have been published for this article.