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Cognitive functioning in a population-based sample of young adults with anxiety disorders

Published online by Cambridge University Press:  16 April 2020

A.E. Castaneda ,
J. Suvisaari ,
M. Marttunen ,
J. Perälä ,
S.I. Saarni ,
T. Aalto-Setälä ,
J. Lönnqvist  and
A. Tuulio-Henriksson
A.E. Castaneda*
Affiliation:
Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Mannerheimintie 166, 00300Helsinki, Finland Department of Psychology, University of Helsinki, Helsinki, Finland
J. Suvisaari
Affiliation:
Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Mannerheimintie 166, 00300Helsinki, Finland Department of Social Psychiatry, Tampere School of Public Health, University of Tampere, Tampere, Finland
M. Marttunen
Affiliation:
Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Mannerheimintie 166, 00300Helsinki, Finland Department of Adolescent Psychiatry, Helsinki University Central Hospital, Helsinki, Finland Department of Psychiatry, University of Helsinki, Helsinki, Finland
J. Perälä
Affiliation:
Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Mannerheimintie 166, 00300Helsinki, Finland
S.I. Saarni
Affiliation:
Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Mannerheimintie 166, 00300Helsinki, Finland Department of Psychiatry, University of Helsinki, Helsinki, Finland
T. Aalto-Setälä
Affiliation:
Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Mannerheimintie 166, 00300Helsinki, Finland Department of Child Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
J. Lönnqvist
Affiliation:
Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Mannerheimintie 166, 00300Helsinki, Finland Department of Psychiatry, University of Helsinki, Helsinki, Finland
A. Tuulio-Henriksson
Affiliation:
Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Mannerheimintie 166, 00300Helsinki, Finland Department of Psychology, University of Helsinki, Helsinki, Finland
*
*Corresponding author.Tel.: +358 20610 8651; fax: +358 20610 8478. E-mail address: anu.castaneda@thl.fi (A.E. Castaneda).
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Abstract

Objective

Cognitive functioning in anxiety disorders has received little investigation, particularly among young adults and in non-clinical samples. The present study examined cognitive functioning in a population-based sample of young adults with anxiety disorders in comparison to healthy peers.

Methods

A population-based sample of 21–35-year-olds with a lifetime history of anxiety disorders (n = 75) and a random sample of healthy controls (n = 71) derived from the same population were compared in terms of performance in neuropsychological tests measuring verbal and visual short-term memory, verbal long-term memory, attention, psychomotor processing speed, and executive functioning.

Results

In general, young adults with anxiety disorders did not have major cognitive impairments when compared to healthy peers. When participants with anxiety disorder in remission were excluded, persons with current anxiety disorder scored lower in visual working memory tests. Current psychotropic medication use and low current psychosocial functioning associated with deficits in executive functioning, psychomotor processing speed, and visual short-term memory.

Conclusions

Lifetime history of anxiety disorders is not associated with cognitive impairment among young adults in the general population. However, among persons with anxiety disorders, current psychotropic medication use and low psychosocial functioning, indicating more severe symptoms, may associate with cognitive impairments.

Keywords

Anxiety disorderNeuropsychologyCognitive impairmentYoung adultGeneral population
Type
Original article
Information
European Psychiatry , Volume 26 , Issue 6 , September 2011 , pp. 346 - 353
Copyright
Copyright © Elsevier Masson SAS 2011

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References

Abbruzzese, M, Ferri, S, Scarone, SWisconsin Card Sorting Test performance in obsessive-compulsive disorder: No evidence for involvement of dorsolateral prefrontal cortex. Psychiatry Res 1995;58:37–43.CrossRefGoogle ScholarPubMed
Abelson, JL, Khan, S, Liberzon, I, Young, EAHPA axis activity in patients with panic disorders: Review and synthesis of four studies. Depress Anxiety 2007;24:66–76.CrossRefGoogle ScholarPubMed
Airaksinen, E, Larsson, M, Forsell, YNeuropsychological functions in anxiety disorders in population-based samples: Evidence of episodic memory dysfunction. J Psychiatr Res 2005;39:207–214.CrossRefGoogle ScholarPubMed
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, DC: American Psychiatric Association; 1994.Google Scholar
Aromaa, A, Koskinen, S, editors. Health and functional capacity in Finland. Baseline results of the Health 2000 Health Examination Survey. Helsinki, Finland: National Public Health Institute; 2004. Available in English at http://www.ktl.fi/terveys2000/index.uk.html. Accessed May 25, 2009.Google Scholar
Asmundson, GJG, Stein, MB, Larsen, DK, Walker, JRNeurocognitive function in panic disorder and social phobia patients. Anxiety 1995;1:201–207.Google Scholar
Barrett, DH, Green, ML, Morris, R, Giles, WH, Croft, JBCognitive functioning and posttraumatic stress disorder. Am J Psychiatry 1996;153:1492–1494.Google ScholarPubMed
Bohne, A, Savage, CR, Deckersbach, T, Keuthen, NJ, Jenike, MA, Tuschen-Caffier, B, et al.Visuospatial abilities, memory, and executive functioning in trichotillomania and obsessive-compulsive disorder. J Clin Exp Neuropsychol 2005;27:385–399.CrossRefGoogle ScholarPubMed
Brewin, CR, Kleiner, JS, Vasterling, JJ, Field, APMemory for emotionally neutral information in posttraumatic stress disorder: A meta-analytic investigation. J Abnorm Psychol 2007;116:448–463.CrossRefGoogle ScholarPubMed
Castaneda, AE, Suvisaari, J, Marttunen, M, Perälä, J, Saarni, SI, Aalto-Setälä, T, et al.Cognitive functioning in a population-based sample of young adults with a history of non-psychotic unipolar depressive disorders without psychiatric comorbidity. J Affect Disord 2008;110:36–45.CrossRefGoogle Scholar
Castaneda, AE, Tuulio-Henriksson, A, Marttunen, M, Suvisaari, J, Lönnqvist, JA review on cognitive impairments in depressive and anxiety disorders with a focus on young adults. J Affect Disord 2008;106:1–27.CrossRefGoogle ScholarPubMed
Castaneda, AE, Marttunen, M, Suvisaari, J, Perälä, J, Saarni, SI, Aalto-Setälä, T, et al.The effect of psychiatric co-morbidity on cognitive functioning in a population-based sample of depressed young adults. Psychol Med 2010;40:29–39.CrossRefGoogle Scholar
Cohen, LJ, Hollander, E, DeCaria, CM, Stein, DJ, Simeon, D, Liebowitz, MR, et al.Specificity of neuropsychological impairment in obsessive-compulsive disorder: A comparison with social phobic and normal control subjects. J Neuropsychiatry Clin Neurosci 1996;8:82–85.Google ScholarPubMed
Crowell, TA, Kieffer, KM, Siders, CA, Vanderploeg, RDNeuropsychological findings in combat-related posttraumatic stress disorder. Clin Neuropsychol 2002;16:310–321.CrossRefGoogle ScholarPubMed
de Kloet, CS, Vermetten, E, Geuze, E, Kavelaars, A, Heijnen, CJ, Westenberg, HGMAssessment of HPA-axis function in posttraumatic stress disorder: Pharmacological and non-pharmacological challenge tests, a review. J Psychiatr Res 2006;40:550–567.CrossRefGoogle ScholarPubMed
Delis, DC, Kramer, JH, Kaplan, E, Ober, BACalifornia Verbal Learning Test: Adult Version. San Antonio, TX: The Psychological Corporation: 1987.Google Scholar
First, MB, Spitzer, RL, Gibbon, M, Williams, JBWStructured clinical interview for DSM-IV-TR Axis I disorders. In: Patient Edition (SCID I/P, 2/2001 Revision) New York, NY: Biometrics Research Department, New York State Psychiatry Institute; 2001.Google Scholar
Fröjd, S, Kaltiala-Heino, R, Rimpelä, MThe association of parental monitoring and family structure with diverse maladjustment outcomes in middle adolescent boys and girls. Nord J Psychiatry 2007;61:296–303.CrossRefGoogle ScholarPubMed
Golier, J, Yehud, RNeuropsychological processes in post-traumatic stress disorder. Psychiatr Clin North Am 2002;25:295–315.CrossRefGoogle ScholarPubMed
Golier, JA, Harvey, PD, Legge, J, Yehuda, RMemory performance in older trauma survivors. Implications for the longitudinal course of PTSD. Ann N Y Acad Sci 2006;1071:54–66.CrossRefGoogle ScholarPubMed
Gladsjo, JA, Rapaport, MH, McKinney, R, Lucas, JA, Rabin, A, Oliver, T, et al.A neuropsychological study of panic disorder: negative findings. J Affect Disord 1998;49:123–131.CrossRefGoogle ScholarPubMed
Graver, CJ, White, PMNeuropsychological effects of stress on social phobia with and without comorbid depression. Behav Res Ther 2007;45:1193–1206.CrossRefGoogle ScholarPubMed
Greisberg, S, McKay, DNeuropsychology of obsessive-compulsive disorder: A review and treatment implications. Clin Psychol Rev 2003;23:95–117.CrossRefGoogle ScholarPubMed
Hemmings, SMJ, Kinnear, CJ, Lochner, C, Niehaus, DJH, Knwles, JA, Moolman-Smook, JC, et al.Early- versus late-onset obsessive-compulsive disoder: Investigating genetic and clinical correlates. Psychiatry Res 2004;128:175–182.CrossRefGoogle Scholar
Henin, A, Savage, CR, Rauch, SL, Deckersbach, T, Wilhelm, S, Baer, L, et al.Is age at symptom onset associated with severity of memory impairments in adults with obsessive-compulsive disorder? Am J Psychiatry 2001;158:137–139.CrossRefGoogle Scholar
Horner, MD, Hamner, MBNeurocognitive functioning in posttraumatic stress disorder. Neuropsychol Rev 2002;12:15–30.CrossRefGoogle ScholarPubMed
Johnsen, GE, Asbjørnsen, AEConsistent impaired verbal memory in PTSD: A meta-analysis. J Affect Disord 2008;111:74–82.CrossRefGoogle ScholarPubMed
Kaplan, JS, Erickson, K, Luckenbaugh, DA, Weiland-Fiedler, P, Geraci, M, Sahakian, BJ, et al.Differential performance on tasks of affective processing and decision-making in patients with panic disorder and panic disorder with comorbid major depressive disorder. J Affect Disord 2006;95:165–171.CrossRefGoogle ScholarPubMed
Kessler, RC, Andrews, G, Colpe, LJ, Hiripi, E, Mroczek, DK, Normand S-LT, , et al.Short screening scales to monitor population prevalences and trends in non-specific psychological distress. Psychol Med 2002;32:959–976.CrossRefGoogle ScholarPubMed
Kessler, RC, Berglund, P, Demler, O, Jin, R, Merikangas, KR, Walters, EELifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005;62:593–602.CrossRefGoogle ScholarPubMed
Kim, M-S, Park, S-J, Shin, MS, Kwon, JSNeuropsychological profile in patients with obsessive-compulsive disorder over a period of 4-month treatment. J Psychiatr Res 2002;36:257–265.CrossRefGoogle Scholar
Koenen, KC, Moffitt, TE, Roberts, AL, Martin, LT, Kubzansky, L, Harrington, H, et al.Childhood IQ and adult mental disorders: a test of the cognitive reserve hypothesis. Am J Psychiatry 2009;166:50–57.CrossRefGoogle ScholarPubMed
Koskinen, S, Kestilä, L, Martelin, T, Aromaa, A, editors. Baseline results of the Health 2000 Study on the health of 18–29-year-olds and the factors associated with it. Finland: Helsinki National Public Health Institute; 2005.Google Scholar
Kuelz, AK, Hohagen, F, Voderholzer, UNeuropsychological performance in obsessive-compulsive disorder: a critical review. Biol Psychol 2004;65:185–236.CrossRefGoogle ScholarPubMed
Kurtz, MMNeurocognitive impairment across the lifespan in schizophrenia: An update. Schizophr Res 2005;74:15–26.CrossRefGoogle ScholarPubMed
Lautenbacher, S, Spernal, J, Krieg, J-CDivided and selective attention in panic disorder. A comparative study of patients with panic disorder, major depression and healthy controls. Eur Arch Psychiatry Clin Neurosci 2002;252:210–213.CrossRefGoogle ScholarPubMed
Lee, BK, Glass, TA, McAtee, MJ, Wand, GS, Bandeen-Roche, K, Bolla, IK, et al.Associations of salivary cortisol with cognitive function in the Baltimore Memory Study. Arch Gen Psychiatry 2007;64:810–818.CrossRefGoogle ScholarPubMed
Lezak, MD, Howieson, DB, Loring, DWNeuropsychological Assessment. 4th ed., New York, NY: Oxford University Press; 2004.Google Scholar
Lucas, JA, Telch, MJ, Bigler, EDMemory functioning in panic disorder: A neuropsychological perspective. J Anxiety Disord 1991;5:1–20.CrossRefGoogle Scholar
Malhi, GS, Ivanovski, B, Szekeres, V, Olley, ABipolar disorder: It's all in your mind? The neuropsychological profile of a biological disorder. Can J Psychiatry 2004;49:813–819.CrossRefGoogle ScholarPubMed
Mataix-Cols, D, van den Heuvel, OACommon and distinct neural correlates of obsessive-compulsive and related disorders. Psychiatr Clin North Am 2006;29:391–410.CrossRefGoogle ScholarPubMed
Mayoral, M, Zabala, A, Robles, O, Bombín, I, Andrés, P, Parellada, M, et al.Neuropsychological functioning in adolescents with first episode psychosis: A two-year follow-up study. Eur Psychiatry 2008;23:375–383.CrossRefGoogle ScholarPubMed
Milliery, M, Bouvard, M, Aupetit, J, Cottraux, JSustained attention in patients with obsessive-compulsive disorder: A controlled study. Psychiatry Res 2000;96:199–209.CrossRefGoogle ScholarPubMed
Moritz, S, Kuelz, AK, Jacobsen, D, Kloss, M, Fricke, SSeverity of subjective cognitive impairment in patients with obsessive-compulsive disorder and depression. J Anxiety Disord 2006;20:427–443.CrossRefGoogle ScholarPubMed
Muller, J, Roberts, JEMemory and attention in obsessive-compulsive disorder: A review. J Anxiety Disord 2005;19:1–28.CrossRefGoogle ScholarPubMed
Nakao, T, Nakagawa, A, Yoshiura, T, Nakatani, E, Nabeyama, M, Sanematsu, Het al.Duration effect of obsessive-compulsive disorder on cognitive function: A functional MRI study. Depress Anxiety 2010;26:814–823.CrossRefGoogle Scholar
Phan, KL, Orlichenko, A, Boyd, E, Angstadt, M, Coccaro, EF, Liberzon, Iet al.Preliminary evidence of white matter abnormality in the uncinate fasciculus in generalized social anxiety disorder. Biol Psychiatry 2009;66:691–694.CrossRefGoogle ScholarPubMed
Purcell, R, Maruff, P, Kyrios, M, Pantelis, CNeuropsychological deficits in obsessive-compulsive disorder. A comparison with unipolar depression, panic disorder, and normal controls. Arch Gen Psychiatry 1998;55:415–423.CrossRefGoogle ScholarPubMed
Raitasalo, RMood Questionnaire. Finnish modification of the short form of the Beck Depression Inventory measuring depression symptoms and self-esteem. Helsinki, Finland: Social Insurance Institute: 2007.Google Scholar
Ranta, K, Kaltiala-Heino, R, Rantanen, P, Marttunen, MSocial phobia in Finnish general adolescent population: prevalence, comorbidity, individual and family correlates, and service use. Depress Anxiety 2009;26:528–536.Google ScholarPubMed
Reitan, RM, Wolfson, DThe Halstead-Reitan Neuropsychological Test Battery: Theory and Clinical Interpretation. Tucson, AC: Neuropsychology Press; 1993.Google Scholar
Roh, KS, Shin, MS, Kim, M-S, Ha, T-H, Shin, Y-W, Lee, KJ, et al.Persistent cognitive dysfunction in patients with obsessive-compulsive disorder: a naturalistic study. Psychiatry Clin Neurosci 2005;59:539–545.CrossRefGoogle ScholarPubMed
Saarni, SI, Suvisaari, J, Sintonen, H, Pirkola, S, Koskinen, S, Aromaa, A, et al.Impact of psychiatric disorders on health-related quality of life: general population survey. Br J Psychiatry 2007;190:326–332.CrossRefGoogle ScholarPubMed
Savitz, J, Solms, M, Ramesar, RNeuropsychological dysfunction in bipolar affective disorder: A critical opinion. Bipolar Disord 2005;7:216–235.CrossRefGoogle ScholarPubMed
Shin, MS, Choi, H, Kim, H, Hwang, JW, Kim, BN, Cho, SCA study of neuropsychological deficit in children with obsessive-compulsive disorder. Eur Psychiatry 2008;23:512–520.CrossRefGoogle ScholarPubMed
SPSS Inc. SPSS 16.0 for Windows. Chicago, IL; 2007.Google Scholar
Suvisaari, J, Aalto-Setälä, T, Tuulio-Henriksson, A, Härkänen, T, Saarni, SI, Perälä, J, et al.Mental disorders in young adulthood. Psychol Med 2009;39:287–300.CrossRefGoogle ScholarPubMed
Szezko, PR, Ardekani, BA, Ashtari, M, Malhotra, AK, Robinson, DG, Bilder, RM, et al.White matter abnormalities in obsessive-compulsive disorder: A diffusion tensor imaging study. Arch Gen Psychiatry 2005;62:782–790.CrossRefGoogle Scholar
Szöke, A, Méary, A, Ferchiou, A, Trandafir, A, Leboyer, M, Schürhoff, FCorrelations between cognitive performances and psychotic or schizotypal dimensions. Eur Psychiatry 2009;24:244–250.CrossRefGoogle ScholarPubMed
Thomas, AJ, Gallagher, P, Robinson, LJ, Porter, RJ, Young, AH, Ferrier, IN, et al.A comparison of neurocognitive impairment in younger and older adults with major depression. Psychol Med 2009;39:725–733.CrossRefGoogle ScholarPubMed
Tükel, R, Ertekin, E, Batmaz, S, Alyanak, F, Sözen, A, Aslantas, B, et al.Influence of age of onset on clinical features in obsessive-compulsive disorder. Depress Anxiety 2005;21:112–117.CrossRefGoogle ScholarPubMed
Twamley, EW, Hami, S, Stein, MBNeuropsychological function in college students with and without posttraumatic stress disorder. Psychiatry Res 2004;126:265–274.CrossRefGoogle ScholarPubMed
van den Heuvel, OA, Veltman, DJ, Groenewegen, HJ, Witter, MP, Merkelbach, J, Cath, DC, et al.Disorder-specific neuroanatomical correlates of attentional bias in obsessive-compulsive disorder, panic disorder, and hypochondriasis. Arch Gen Psychiatry 2005;62:922–933.CrossRefGoogle ScholarPubMed
Wechsler, DWechsler Adult Intelligence Scale, Revised. San Antonio, TX: The Psychological Corporation; 1981.Google Scholar
Wechsler, DWechsler Memory Scale, Revised. San Antonio, TX: The Psychological Corporation; 1987.Google Scholar
Wechsler, D, WAIS-R, Käsikirja. Wechslerin aikuisten älykkyysasteikko [in Finnish], Helsinki, Finland: Psykologien kustannus Oy; 1992.Google Scholar
Wechsler, DWechsler Adult Intelligence Scale. 3rd ed., San Antonio, TX: The Psychological Corporation; 1997.Google Scholar
Wolf, OTStress and memory in humans: Twelve years of progress? Brain Res 2009;1293:142–54.CrossRefGoogle ScholarPubMed
Zalewski, C, Thompson, W, Gottesman, IComparison of neuropsychological test performance in PTSD, generalized anxiety disorder, and control Vietnam veterans. Assessment 1994;1:133–142.CrossRefGoogle ScholarPubMed
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