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Combined clozapine-lithium treatment for schizophrenia and schizoaffective disorder

Published online by Cambridge University Press:  16 April 2020

M Moldavsky ,
D Stein ,
R Benatov ,
P Sirota ,
A Elizur ,
Y Matzner  and
A Weizman
M Moldavsky
Affiliation:
Abarbanel Mental Health Center, 15 Keren Kayemet St, Bat-Yam, 59100, Israel affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
D Stein
Affiliation:
Abarbanel Mental Health Center, 15 Keren Kayemet St, Bat-Yam, 59100, Israel affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
R Benatov
Affiliation:
Abarbanel Mental Health Center, 15 Keren Kayemet St, Bat-Yam, 59100, Israel affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
P Sirota
Affiliation:
Abarbanel Mental Health Center, 15 Keren Kayemet St, Bat-Yam, 59100, Israel affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
A Elizur
Affiliation:
Abarbanel Mental Health Center, 15 Keren Kayemet St, Bat-Yam, 59100, Israel affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Y Matzner
Affiliation:
Hematology Unit, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel
A Weizman
Affiliation:
Geha Psychiatric Hosvital and Felsenstein Medical Research Center, Beilinson Medical Campus, Petah Tiqva, Israel affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv , Israel
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Summary

Three adolescent and two adult patients suffering from chronic excited psychoses (either schizophrenia or schizoaffective disorder) resistant to traditional neuroleptics and clozapine were treated with combined clozapine-lithium. Improvement was assessed with the Positive and Negative Symptoms Scale, the Brief Psychiatric Rating Scale and the Clinical Global Impressions, administered before and during combined clozapine-lithium treatment. All patients demonstrated a significant improvement with this combination. There was no occurrence of agranulocytosis, neuroleptic malignant syndrome or other clinically significant adverse effects.

Keywords

clozapinelithiumschizophreniaschizoaffective disorder
Type
Short communication
Information
European Psychiatry , Volume 13 , Issue 2 , 1998 , pp. 104 - 106
Copyright
Copyright © Elsevier, Paris 1998

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