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Co-morbid anxiety disorders predict early relapse after inpatient alcohol treatment

Published online by Cambridge University Press:  15 April 2020

A.F.A. Schellekens ,
C.A.J. de Jong ,
J.K. Buitelaar  and
R.J. Verkes
A.F.A. Schellekens*
Affiliation:
Radboud Medical Centre Nijmegen, Department of Psychiatry, 966, PO Box 9101, Reinier Postlaan 10, 6500 HB, Nijmegen, The Netherlands Nijmegen Institute for Science Practitioners in Addiction (NISPA) Radboud University Nijmegen, The Netherlands
C.A.J. de Jong
Affiliation:
Nijmegen Institute for Science Practitioners in Addiction (NISPA) Radboud University Nijmegen, The Netherlands
J.K. Buitelaar
Affiliation:
Radboud Medical Centre Nijmegen, Department of Psychiatry, 966, PO Box 9101, Reinier Postlaan 10, 6500 HB, Nijmegen, The Netherlands Radboud University Nijmegen, The Netherlands
R.J. Verkes
Affiliation:
Department of Cognitive Neuroscience, University Medical Centre Radboud University Nijmegen, The Netherlands
*
*Corresponding author. E-mail address: a.f.a.schellekens@psy.umcn.nl (A.F.A. Schellekens).
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Abstract

Introduction:

Alcohol dependence and anxiety disorders often co-occur. Yet, the effect of co-morbid anxiety disorders on the alcohol relapse-risk after treatment is under debate. This study investigated the effect of co-morbid anxiety disorders on relapse rates in alcohol dependence. We hypothesized that co-morbid anxiety disorders would be particularly predictive for early relapse, but not late relapse.

Subjects and methods:

In a prospective design, male alcohol dependent patients (n = 189) were recruited from an inpatient detoxification clinic. Psychiatric diagnoses and personality traits were assessed using the Mini International Neuropsychiatric Interview for psychiatric disorders and the Temperament and Character Inventory. The addiction severity index was used to assess addiction severity and follow-up.

Results:

One year after detoxification, 81 patients (53%) relapsed and nine patients (7%) were deceased, due to alcohol related causes. Co-morbid anxiety disorder, marital status, addiction severity, in particular legal problems, and harm avoidance predicted relapse. Anxiety disorders specifically predicted early relapse.

Conclusion:

Alcohol dependence is a severe mental disorder, with high relapse rates and high mortality. Alcohol dependent patients with co-morbid anxiety disorders are particularly prone to relapse during the first three months of treatment. These patients may therefore require additional medical and psychological attention.

Keywords

Substance use disordersAnxietyMortalityTemperament and character inventoryTreatment
Type
Original article
Information
European Psychiatry , Volume 30 , Issue 1 , January 2015 , pp. 128 - 136
Copyright
Copyright © European Psychiatric Association 2020

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