Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-11T07:25:53.851Z Has data issue: false hasContentIssue false
  • English
  • Français

Comparative study of the effects of zopiclone (7.5 mg), zolpidem, flunitrazepam and a placebo on nocturnal cognitive performance in healthy subjects, in relation to pharmacokinetics

Published online by Cambridge University Press:  16 April 2020

H Allain ,
A Patat ,
A Lieury ,
F Le Coz ,
C Janus ,
G Menard  and
JM Gandon
H Allain
Affiliation:
Laboratoire de Pharmacologie Expérimentale et Clinique, Faculté de Médecine, av du Professeur Léon-Bernard, 35043Rennes, France
A Patat
Affiliation:
Biotrial SA, 20 rue du Professeur Jean-Pecker; Technopole Rennes-Atlantique, 35000Rennes, France
A Lieury
Affiliation:
Département de Psychologie Expérimentale et Clinique, Université de Rennes II, av Gaston-Berger, 35043Rennes, France
F Le Coz
Affiliation:
Biotrial SA, 20 rue du Professeur Jean-Pecker; Technopole Rennes-Atlantique, 35000Rennes, France
C Janus
Affiliation:
Théraplix, 46-52 rue Albert, 75013, Paris, France
G Menard
Affiliation:
Laboratoire de Pharmacologie Expérimentale et Clinique, Faculté de Médecine, av du Professeur Léon-Bernard, 35043Rennes, France
JM Gandon
Affiliation:
Biotrial SA, 20 rue du Professeur Jean-Pecker; Technopole Rennes-Atlantique, 35000Rennes, France
Get access

Summary

The effect of zopiclone (7.5 mg) on attention, vigilance and memory components was evaluated during a nocturnal period in comparison to a placebo, to zolpidem (10 mg) and to flunitrazepam (1 mg) in a double blind, randomized study, after administration of a single dose in 16 young healthy volunteers. It appears that there is a clear effect on attention and vigilance; this effect is apparent during the kinetic phase of the absorption of the medication. The effect on memory is transient and is absent four hours after the ingestion of the drug. The objective results are not strictly consistent with the chronology of the subjective parameters (Leeds scale — Visual Analogue Scale). The three hypnotics under comparison do not fundamentally differ except in their kinetic/pharmacodynamic effect relationship. One important fact, taking the parameters as a whole, is that there is no objective “residual” effect.

Keywords

zopiclonehypnoticsbenzodiazepinescognitive functionsvigilancememory
Type
Research Article
Information
European Psychiatry , Volume 10 , Issue S3: Satellite Symposium to the AEP Congress , 1995 , pp. 129s - 135s
Copyright
Copyright © Elsevier, Paris 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Allain, HLieury, ABureau, MGandon, JMZopiclone et processus mnésiques. In: Grivois, H et al,eds. Workshop, Florence 18-19 Sept 1992 par Lab Theraplix Zopiclone 1987–1992:5 années de pratique clinique Paris: Elsevier, 1992 93–116Google Scholar
Allain, HLieury, AGandon, JMPsychopharmacology of memory components. In: Hindmarch, IStonier, PJ eds. Human Psychopharmacology: measures and methods London: John Wiley and Sons Ltd, 1993;4:143–4Google Scholar
Allain, HZolpidem: five years on. Sleep 1995;18(3): in pressGoogle Scholar
Bensimon, GForet, JWarot, DLacomblez, LThiercelin, JFSimon, PDaytime wakefulness following a bedtime oral dose of zolpidem 20 mg, flunitrazepam 2 mg and placebo. Br J Clin Pharmacol 1990;30(3):463–9Google ScholarPubMed
Craik, FIMTulving, EDepth processing and the retention of words in episodic memory. J Exp Psychol 1975; 104: 268–94CrossRefGoogle Scholar
Debruyne, DLacotte, JHurault de Ligny, BMoulin, MDetermination of zolpidem and zopiclone in serum by capillary column gaz chromatography. J Pharm Sci 1991; 80(1): 71–4CrossRefGoogle Scholar
Dujardin, KDerambure, PGuieu, JDBorderies, PLeconte, PEffects of zolpidem 10mg on cognitive performance: an extensive investigation. J Sleep Res 1992;1(suppl 1):64Google Scholar
Fairweather, DBKerr, JSHindmarch, IThe effects of acute and repeated doses of zolpidem on subjective sleep, psychomotor performance and cognitive function in elderly volunteers. EurJ Clin Pharmacol 1992;43(6):597–601CrossRefGoogle ScholarPubMed
Gaillot, JHeusse, DHougton, GWMarc-Aurele, JDreyfus, JFPharmacokinetics and metabolism of zopiclone. Pharmacology 1983; 27(suppl 2):76–91CrossRefGoogle ScholarPubMed
Grannen, AWennerlund, PDahlstrom, BEckernas, SAInter-and intra-individual variability in the concentration-effect (sedation) relationship of flunitrazepam. Br J Clin Pharmacol 1991; 31(1): 89–92CrossRefGoogle Scholar
Hindmarch, IImmediate overnight effects of zopiclone 7.5 mg and nitrazepam 5 mg with ethanol on psychomotor performance and memory in healthy volunteers. Int Clin Psychopharmacol 1990; 5(suppl 2):105–13Google ScholarPubMed
Kapteyn, TSBles, WNjiokiktjien, CJKodde, LMassen, CHMol, JMStandardization in plateform stabilometry being a part of posturography. Agressologie 1983;247:321–6Google Scholar
Lieury, ADeux cerveaux pour une bouche. Langues phonétiques pictographiques et spécialisation hémisphérique. Glossa, Les Cahiers de l'Unadrio 1991; 24: 2–8Google Scholar
Lister, RGWeingartner, HEckardt, MJLinnoila, MClinical relevance of effects of benzodiazepines on learning and memory. Psychopharmacol Ser 1988; 6: 117–27Google ScholarPubMed
Lister, RGThe amnesic action of benzodiazepines in man. Neurosci Biobehav Rev 1985; 9(1): 87–94CrossRefGoogle ScholarPubMed
Matila, MAKLami, HMFlunitrazepam: a review of its pharmacological properties and therapeutic use. Drugs 1980; 20: 353–74CrossRefGoogle Scholar
McClelland, GRBody sway the effects of psychoactive drugs. A review. Human Psychopharmacol 1989; 4(1): 3–14CrossRefGoogle Scholar
Ott, HRohloff, AAufdembrinke, BFichte, KAnterograde and retrograde amnesia after lormetazepam and flunitrazepam. Psychopharmacol Ser 1988; 6: 80–193Google ScholarPubMed
Parrot, ACHindmarch, IFactor analysis of a sleep evaluation questionnaire. Psychol Med 1978; 8: 325–9CrossRefGoogle Scholar
Patat, AFoulhoux, PEffect on postural sway of various benzodiazepine tranquillizers. Br J Clin Pharmacol 1985; 20(1): 9–16CrossRefGoogle ScholarPubMed
Patat, AKlein, MJHucher, MGranier, JAcute effects of amitriptyline on human performance and interactions with diazepamEurJ. Clin Pharmacol 3561988 585–92Google Scholar
Wickstrom, EGodtlibsen, OBBredesen, JEJensen, MHPerformance and mood following partial sleep deprivation: a randomized doubleblind cross-over study of zopiclone, triazolam, flunitrazepam, ethanol and placebo. Hum Psychopharmacol 1988; 3(1): 3–11Google Scholar
Submit a response

Comments

No Comments have been published for this article.