Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-25T19:46:29.640Z Has data issue: false hasContentIssue false
  • English
  • Français

Correlations between cognitive performances and psychotic or schizotypal dimensions

Published online by Cambridge University Press:  16 April 2020

Andrei Szöke ,
Alexandre Méary ,
Aziz Ferchiou ,
Anca Trandafir ,
Marion Leboyer  and
Franck Schürhoff
Andrei Szöke*
Affiliation:
INSERM U955, 94000Créteil, France Université Paris 12, Faculté de Médecine, IFR 10, 94000, Créteil, France AP-HP, Groupe “Chenevier-Mondor”, Pôle de Psychiatrie, 94000Créteil, France
Alexandre Méary
Affiliation:
INSERM U955, 94000Créteil, France Université Paris 12, Faculté de Médecine, IFR 10, 94000, Créteil, France AP-HP, Groupe “Chenevier-Mondor”, Pôle de Psychiatrie, 94000Créteil, France
Aziz Ferchiou
Affiliation:
INSERM U955, 94000Créteil, France Université Paris 12, Faculté de Médecine, IFR 10, 94000, Créteil, France AP-HP, Groupe “Chenevier-Mondor”, Pôle de Psychiatrie, 94000Créteil, France
Anca Trandafir
Affiliation:
AP-HP, Groupe “Chenevier-Mondor”, Pôle de Psychiatrie, 94000Créteil, France
Marion Leboyer
Affiliation:
INSERM U955, 94000Créteil, France Université Paris 12, Faculté de Médecine, IFR 10, 94000, Créteil, France AP-HP, Groupe “Chenevier-Mondor”, Pôle de Psychiatrie, 94000Créteil, France
Franck Schürhoff
Affiliation:
INSERM U955, 94000Créteil, France Université Paris 12, Faculté de Médecine, IFR 10, 94000, Créteil, France AP-HP, Groupe “Chenevier-Mondor”, Pôle de Psychiatrie, 94000Créteil, France
*
*Corresponding author. Pôle de Psychiatrie, Hôpital “A. Chenevier”, 40, rue de Mesly, 94000 Créteil, France. Tel.: +33 (0) 149813051; fax: +33 (0) 149813059. E-mail address: andrei.szoke@ach.aphp.fr
Get access

Abstract

Objective

To test if specific correlations exist between cognitive measures and psychotic dimensions in schizophrenic subjects and if similar correlations, between cognition and schizotypal dimensions, are present in non-psychotic subjects.

Methods

We administered the same battery of cognitive tests (Source Monitoring, Verbal Fluency [VF] and Stroop tests) to schizophrenic subjects (N = 54), their first-degree relatives (N = 37) and controls (N = 41). Scores of negative, positive and disorganisation dimensions were derived from the Signs and Symptoms of Psychotic Illness scale in schizophrenic subjects, and from the Schizotypal Personality Questionnaire in relatives and controls.

Results

In schizophrenic subjects, as hypothesised, the negative dimension correlated with performance on VF and disorganisation with performance in the Stroop test. The positive dimension did not correlate with any cognitive measure.

With only one exception, the significant correlations observed in non-psychotic subjects did not match correlations seen in schizophrenic subjects. In non-psychotic subjects greater disorganisation was associated with more clustered words in VF suggesting that excessive automatic spreading of activation in semantic networks could underlie this dimension.

Conclusion

As a whole, data lent partial support to our hypothesis of specific cognitive–clinical correlations in schizophrenic subjects but did not support the existence of similar correlations in non-psychotic subjects.

Keywords

SchizophreniaSchizotypalDisorganisationCognitionVerbal fluency
Type
Original article
Information
European Psychiatry , Volume 24 , Issue 4 , May 2009 , pp. 244 - 250
Copyright
Copyright © Elsevier Masson SAS 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association, Diagnostic and statistical manual of mental disorders 4th ed.Washington, DCAmerican Psychiatric Association 1994Google Scholar
Armitage, P., Berry, G., Matthews, J.N.S.Statistical methods in medical research 4th ed.OxfordBlackwell Science 2002CrossRefGoogle Scholar
Baxter, R.D., Liddle, P.F.Neuropsychological deficits associated with schizophrenic syndromes. Schizophr Res 1998;30(3):239–249CrossRefGoogle ScholarPubMed
Bech, P., Bolwig, T.G., Kramp, P., Rafaelsen, O.J.The Bech–Rafaelsen Mania Scale and the Hamilton depression scale. Acta Psychiatr Scand 1979;59(4):420–430CrossRefGoogle ScholarPubMed
Brébion, G., Amador, X., David, A., Malaspina, D., Sharif, Z., Gorman, J.M.Positive symptomatology and source monitoring failure in schizophrenia: an analysis of symptom-specific effects. Psychiatry Res 2000;95(2):119–131CrossRefGoogle ScholarPubMed
Brébion, G., Gorman, J.M., Amador, X., Malaspina, D., Sharif, Z.Source monitoring in schizophrenia: characterisation and associations with positive and negative symptomatology. Psychiatry Res 2002;112(1):27–39CrossRefGoogle ScholarPubMed
Brekke, J.S., Raine, A., Thomson, C.Cognitive and psychophysiological correlates of positive, negative, and disorganized symptoms in the schizophrenia spectrum. Psychiatry Res 1995;57(3):241–250CrossRefGoogle ScholarPubMed
Dibben, C.R., Rice, C., Laws, K., McKenna, P.J.Is executive impairment associated with schizophrenic syndromes? A meta-analysis. Psychol Med 2008;30:1–12 [Epub ahead of print]Google Scholar
Dinn, W.M., Harris, C.L., Aycicegi, A., Greene, P., Andover, M.S.Positive and negative schizotypy in a student sample: neurocognitive and clinical correlates. Schizophr Res 2002;56(1–2):171–185CrossRefGoogle Scholar
Ditman, T., Kuperberg, G.R.A source-monitoring account of auditory verbal hallucinations in patients with schizophrenia. Harv Rev Psychiatry 2005;13(5):280–299CrossRefGoogle ScholarPubMed
Dumas, P., Bouafia, S., Gutknecht, C., Saoud, M., Dalery, J., d'Amato, T.Validation de la version française du questionnaire de personnalité schizotypique de Raine – approche catégorielle et dimensionnelle des traits de personnalité schizotypique dans une population d'étudiants. Encéphale 2000;26(5):315–322Google Scholar
Franck, N., Rouby, P., Daprati, E., Dalery, J., Marie-Cardine, M., Georgieff, N.Confusion between silent and overt reading in schizophrenia. Schizophr Res 2000;41(2):357–364CrossRefGoogle Scholar
Frith CD. The cognitive neuropsychology of schizophrenia. Lawrence Erlbaum. Hove.Google Scholar
Good, K.P., Rabinowitz, J., Whitehorn, D., Harvey, P.D., DeSmedt, G., Kopala, L.C.The relationship of neuropsychological test performance with the PANSS in antipsychotic naïve, first-episode psychosis patients. Schizophr Res 2004;68(1):11–19CrossRefGoogle ScholarPubMed
Gouzoulis-Mayfrank, E., Voss, T., Mörth, D., Thelen, B., Spitzer, M., Meincke, U.Semantic hyperpriming in thought-disordered patients with schizophrenia: state or trait?–a longitudinal investigation. Schizophr Res 2003;65(2–3):65–73CrossRefGoogle ScholarPubMed
Grube, B.S., Bilder, R.M., Goldman, R.S.Meta-analysis of symptom factors in schizophrenia. Schizophr Res 1998;31(2–3):113–120CrossRefGoogle Scholar
Harvey, P.D., Koren, D., Reichenberg, A., Bowie, C.R.Negative symptoms and cognitive deficits: what is the nature of their relationship?. Schizophr Bull 2006;32(2):250–258CrossRefGoogle ScholarPubMed
Heydebrand, G., Weiser, M., Rabinowitz, J., Hoff, A.L., DeLisi, L.E., Csernansky, J.G.Correlates of cognitive deficits in first episode schizophrenia. Schizophr Res 2004;68(1):1–9CrossRefGoogle ScholarPubMed
Houenou, J., Szöke, A., Méary, A., Loze, J.-Y., Mathieu, F., Leboyer, M.et al.Psychometric properties of the French version of the signs and symptoms of psychotic illness (SSPI) scale. Encéphale 2007;33(5):744–750CrossRefGoogle ScholarPubMed
Howanitz, E., Cicalese, C., Harvey, P.D.Verbal fluency and psychiatric symptoms in geriatric schizophrenia. Schizophr Res 2000;42(3):167–169CrossRefGoogle ScholarPubMed
Keefe, R.S.E., Arnold, M.C., Bayen, U.J., McEvoy, J.P., Wilson, W.H.Source monitoring deficits for self-generated stimuli in schizophrenia: multinomial modelling of data from three sources. Schizophr Res 2002;57(1):51–67CrossRefGoogle Scholar
Kerns, J.G.Schizotypy facets, cognitive control, and emotion. J Abnorm Psychol 2006;115(3):418–427CrossRefGoogle ScholarPubMed
Kircher, T.T., Liddle, P.F., Brammer, M.J., Williams, S.C., Murray, R.M., McGuire, P.K.Reversed lateralization of temporal activation during speech production in thought disordered patients with schizophrenia. Psychol Med 2002;32(3):439–449CrossRefGoogle ScholarPubMed
Liddle, P.F., Morris, D.L.Schizophrenic syndromes and frontal lobe performance. Br J Psychiatry 1991;158(3):340–345CrossRefGoogle ScholarPubMed
Liddle, P.F., Ngan, E.T.C., Duffield, G., Kho, K., Warren, A.J.Signs and symptoms of psychotic illness (SSPI): a rating scale. Br J Psychiatry 2002;180(1):45–50CrossRefGoogle ScholarPubMed
Liddle, P.F.Schizophrenic syndromes, cognitive performance and neurological dysfunction. Psychol Med 1987;17(1):49–57CrossRefGoogle ScholarPubMed
Maxwell, M.E.Family interview for genetic studies Clinical Neurogenetic Branch, Intramural Research Program, NIMH 1992Google Scholar
Montgomery, S.A., Asberg, M.A new depression scale designed to be sensitive to change. Br J Psychiatry 1979;134(4):382–389CrossRefGoogle ScholarPubMed
Moritz, S., Andresen, B., Domin, F., Martin, T., Probsthein, E., Kretschmer, G.et al.Increased automatic spreading activation in healthy subjects with elevated scores in a scale assessing schizophrenic language disturbances. Psychol Med 1999;29(1):161–170CrossRefGoogle Scholar
Nurnberger, J.I. Jr.Blehar, M.C., Kaufmann, C.A., York-Cooler, C., Simpson, S.G., Harkavy-Friedman, J.et al.Diagnostic interview of genetic studies. Rationale, unique features and training. NIMH Genetics Initiative. Arch Gen Psychiatry 1994;51(11):849–859CrossRefGoogle ScholarPubMed
Preisig, M., Fenton, B.T., Matthey, M.L., Berney, A., Ferrero, F.Diagnostic interview for genetic studies (DIGS): inter-rater and test–retest reliability of the French version. Eur Arch Psychiatry Clin Neurosci 1999;249(4):174–179CrossRefGoogle ScholarPubMed
Raine, A.The SPQ: a scale for the assessment of schizotypal personality based on DSM III R criteria. Schizophr Bull 1991;17(4):555–564CrossRefGoogle ScholarPubMed
Rocca P, Castagna F, Marchiaro L, Rasetti R, Rivoira E, Bogetto F. Neuropsychological correlates of reality distortion in schizophrenic patients. Psychiatry Res; 145:49–60.CrossRefGoogle Scholar
Suhr, J.A., Spitznagel, M.B.Factor versus cluster models of schizotypal traits. II: relation to neuropsychological impairment. Schizophr Res 2001;52(3):241–250CrossRefGoogle ScholarPubMed
Torres, I.J., O'Leary, D.S., Andreasen, N.C.Symptoms and interference from memory in schizophrenia: evaluation of Frith's model of willed action. Schizophr Res 2004;69:35–43CrossRefGoogle ScholarPubMed
Troyer, A.K., Moscovitch, M., Winocur, G.Clustering and switching as two components of verbal fluency: evidence from younger and older healthy adults. Neuropsychology 1997;11(1):138–146CrossRefGoogle ScholarPubMed
Vinogradov, S., Willis-Shore, J., Poole, J.H., Marten, E., Ober, B.A., Shenaut, G.K.Clinical and neurocognitve aspects of source monitoring errors in schizophrenia. Am J Psychiatry 1997;154(11):1530–1537CrossRefGoogle Scholar
Vollema, M.G., Postma, B.Neurocognitive correlates of schizotypy in first degree relatives of schizophrenia patients. Schizophr Bull 2002;28(3):367–377CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.