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Cyclic alternating pattern (CAP) rate in the polygraphic investigation of classic and novel hypnotic drugs

Published online by Cambridge University Press:  16 April 2020

L Parrino ,
G Fioriti  and
MG Terzano
L Parrino
Affiliation:
Sleep Disorders Center, Department of Neurology, University of Parma, Via del Quartiere 4, 43100Parma
G Fioriti
Affiliation:
Service of Occupational Health, USL ‘Bassa Est’, Parma, Italy
MG Terzano*
Affiliation:
Sleep Disorders Center, Department of Neurology, University of Parma, Via del Quartiere 4, 43100Parma
*
*Correspondence and reprints.
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Summary

The difficulty to recruit homogeneous samples of insomniacs requires alternative approaches for sleep studies. Acoustic perturbation in healthy volunteers made it possible to determine an experimental model of acute situational insomnia in order to investigate the effects of classic and novel hypnotic compounds. Unfortunately, the traditional scoring parameters of sleep are inadequate to provide reliable information for defining the neurophysiological bases of insomnia and for evaluating the efficacy of hypnotic drugs. Recent studies on the microstructure of sleep have permitted to identify a specific EEG feature, the cyclic alternating pattern (CAP), correlated with the subjective appreciation of sleep quality. Comparing placebo, zolpidem, zopiclone, lorazepam and triazolam, given at equivalent therapeutic doses in middle-aged healthy volunteer subjects under basal conditions and under acute situational insomnia, provided non-significant information when using classical sleep parameters whereas CAP rate (the percentage ratio of CAP time to non-REM sleep time) permitted to discriminate the basal nights from the perturbed nights and the drug nights from the placebo nights. These data have been confirmed in clinical studies using zolpidem versus placebo in chronic insomniacs.

Keywords

sleeppolysomnographyinsomniacyclic alternating patternhypnotic drugs
Type
Research Article
Information
European Psychiatry , Volume 11 , Issue S1: Sleep disorders: epidemiology, social impact and treatment attitudes - Symposium to the AEP Congress , 1996 , pp. 15s - 19s
Copyright
Copyright © 1996 Elsevier, Paris

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References

Kurtz, DSauvanet, JPPharmacologie clinique des hypnotiques, quelles recommendations? In Strauch, GMorselli, PLPharmacologie Clinique: Actualités et Perspectives II Paris. Les Editions INSERM, 1988; 61–77Google Scholar
Kunz, DA methodology for studying hypnoticsBarthouil, PInsomnie et Imidazopyridines Amsterdam: Excerpta Medica 1990; 185–191Google Scholar
Rechtschaffen, AKales, AA manual of standardized terminology, techniques and scoring system for sleep stages of human subjects Brain Information Service/Brain Research InstituteLos Angeles: University of California at Los Angeles 1968Google Scholar
Terzano, MGMancia, DSalati, MRCostani, GDecembrino, AParrino, LThe cyclic alternating pattern as a physiologic component of normal NREM sleep. Sleep 1985; 8: 137–145CrossRefGoogle ScholarPubMed
Terzano, MGParrino, LFioriti, GSpaggiari, MCPiroli, AMorphologic and functional features of cyclic alternating pattern (CAP) sequences in normal NREM sleep. Funct Neurol 1986; 1: 29–41Google ScholarPubMed
Terzano, MGParrino, LSpaggiari, MCThe cyclic alternating pattern sequences in the dynamic organization of sleep. Electroenceph Clin Neurophysiol 1988; 69: 437–447CrossRefGoogle Scholar
Terzano, MGParrino, LFioriti, GOrofiamma, BDepoortere, HModifications of sleep structure induced by increasing levels of acoustic perturbation in normal subjects. Electroenceph Clin Neurophysiol 1990; 76: 29–38CrossRefGoogle ScholarPubMed
Terzano, MGParrino, LEvaluation of EEG cyclic alternating pattern during sleep in insomniacs and controls under placebo and acute treatment with zolpidem. Sleep 1992; 15: 64–70CrossRefGoogle ScholarPubMed
Terzano, MGParrino, LClinical applications of cyclic alternating pattern. Physiol Behav 1993; 54: 807–813CrossRefGoogle ScholarPubMed
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