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CYP2C19 expression modulates affective functioning and brain anatomy – a large single-center community-dwelling cohort study

Published online by Cambridge University Press:  01 September 2022

C. Grosu ,
O. Trofimova ,
M. Gholam ,
M.-P. Strippoli ,
F. Kherif ,
A. Lutti ,
M. Preisig ,
B. Draganski  and
C. Eap
C. Grosu*
Affiliation:
Lausanne University Hospital, Psychiatry, Prilly, Switzerland
O. Trofimova
Affiliation:
Lausanne University Hospital, Psychiatry, Lausanne, Switzerland
M. Gholam
Affiliation:
Lausanne University Hospital, Psychiatry, Prilly, Switzerland
M.-P. Strippoli
Affiliation:
Lausanne University Hospital, Psychiatry, Prilly, Switzerland
F. Kherif
Affiliation:
Lausanne University Hospital, Psychiatry, Lausanne, Switzerland
A. Lutti
Affiliation:
Lausanne University Hospital, Psychiatry, Lausanne, Switzerland
M. Preisig
Affiliation:
Lausanne University Hospital, Psychiatry, Prilly, Switzerland
B. Draganski
Affiliation:
Lausanne University Hospital, Psychiatry, Lausanne, Switzerland
C. Eap
Affiliation:
Lausanne University Hospital, Psychiatry, Prilly, Switzerland
*
*Corresponding author.

Abstract

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Introduction

The association between CYP2C19 poor metabolizer status, depressive symptom severity and hippocampal volume in humans is controversial. Progress in understanding not only the pathophysiology of depression but also potential protective mechanisms is important both for daily clinical practice and for the development of new antidepressant therapies.

Objectives

To test and validate previous findings regarding the impact of CYP2C19 status on depressive symptoms and to examine whether it could influence hippocampus subregions and brain tissue microstructure.

Methods

A total of 4152 individuals from the Longitudinal cohort in the community-dwelling adult population - Colaus|PsyCoLaus in Lausanne, Switzerland were included. They have participated in at least one psychiatric evaluation. Brain anatomy patterns using a comprehensive set of psychometry, water diffusion- and relaxometry-based magnetic resonance imaging data were analysed in a subset of the cohort (BrainLaus, n=1187).

Results

In this population-based cohort study, better lifetime global assessment of functioning scores were observed in poor metabolizers when compared to other metabolizers, this result was mainly driven by female participants (ß=3.9, P=0.01). Examination of brain imaging data revealed that higher right hippocampal subiculum volume was related to poor metabolizer status (ß=0.03, P=0.006). In addition, associations were observed between metabolizer status and white matter microstructure in the left uncinate fasciculus (ß=-0.01, P=0.01) and the left cingulum bundle (ß=-0.01, P=0.01).

Conclusions

CYP2C19 status is associated with modifications in lifetime global functioning, and brain anatomy. Such differences in brain structures can contribute to explain the protective effect of CYP2C19 poor metabolizer status.

Disclosure

No significant relationships.

Keywords

CYP2C19behaviorGlobal Assessment of FunctioningHippocampus
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S120
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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