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Delta and theta eeg activity during resting state is altered in patients affected by major depression

Published online by Cambridge University Press:  13 August 2021

C. Spironelli ,
F. Fusina  and
A. Angrilli
C. Spironelli
Affiliation:
Padova Neuroscience Center, Università degli Studi di Padova, Padova, Italy
F. Fusina*
Affiliation:
Padova Neuroscience Center, Università degli Studi di Padova, Padova, Italy Department Of General Psychology, Università degli Studi di Padova, Padova, Italy
A. Angrilli
Affiliation:
Padova Neuroscience Center, Università degli Studi di Padova, Padova, Italy Department Of General Psychology, Università degli Studi di Padova, Padova, Italy
*
*Corresponding author.

Abstract

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Introduction

Major depression (MD) is associated with cognitive and behavioral alterations in many domains. It is not well clear what cortical structures and functional alterations characterize MD patients during resting state, a condition during which mind wandering process is prevailing.

Objectives

In MD patients with severe levels of depression we expected, during resting state, an altered asymmetry of cortical activity in the EEG bands that generally mark neurological impairment, i.e. Delta and Theta EEG bands.

Methods

30 MD patients under pharmacological treatment and 32 matched controls underwent an EEG recording (38 scalp sites) during 5 min resting state with open eyes. Eye movements were corrected by ICA modeling and the 5 min recording was divided in 2 sec epochs from which Delta and Theta spectral powers were extracted.

Results

Spectral analysis of the 5 min resting state revealed a significant difference between the two groups at the level of left temporal lobe. MD patients showed larger Delta and Theta spectral power in the left superior temporal gyrus at the level of Brodmann’s Areas 22 and 42.

Conclusions

Results evidenced a cortical inhibition (greater EEG Delta and Theta activity) in left temporal linguistic areas in severe depression, a result pointing to a different mind wandering process and thought architecture in MD patients during resting state.

Keywords

Major DepressionEEG bandsresting statepsychophysiology
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S338 - S339
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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