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Depression in Alzheimer’s disease: is there a temporal relationship between the onset of depression and the onset of dementia?

Published online by Cambridge University Press:  16 April 2020

Reinhard Heun ,
Martin Kockler  and
Ursula Ptok
Reinhard Heun*
Affiliation:
Department of Psychiatry of the University of Bonn, Sigmund Freud Str. 25, 53105Bonn, Germany
Martin Kockler
Affiliation:
Department of Psychiatry of the University of Bonn, Sigmund Freud Str. 25, 53105Bonn, Germany
Ursula Ptok
Affiliation:
Department of Psychiatry of the University of Bonn, Sigmund Freud Str. 25, 53105Bonn, Germany
*
*Corresponding author. E-mail address:heun@uni-bonn.de (R. Heun).
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Summary

Alzheimer’s disease (AD) patients often present with concurrent major depression (MD). To investigate the reasons for this comorbidity, e.g. MD being a risk factor for AD, or both diagnoses having a common neurobiology, the temporal relationship between the first onset of AD and of MD during lifetime was investigated—57 out of 146 AD patients had a lifetime diagnosis of MD. The correlation between the ages at onset of MD and dementia was calculated. The incidence of MD in AD patients in several 5-year-intervals before and after the onset of AD was compared with the average incidence of MD in the present AD sample and with the expected incidence of MD in the general population. No significant correlation between the onset of AD and of MD could be found after controlling for age, gender and the Mini-Mental-State. However, the incidence of MD 5 years before and after the onset of AD significantly exceeded the expected incidences—MD is only partially related to AD. However, the increased incidence of MD within 5 years before and after the onset of dementia may indicate that a common neurobiological process causes cognitive decline and depression in a subsample of AD patients.

Keywords

Alzheimer’s diseaseMajor depressionDementiaComorbidityAge at onset
Type
Original article
Information
European Psychiatry , Volume 17 , Issue 5 , September 2002 , pp. 254 - 258
Copyright
Copyright © European Psychiatric Association 2002

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References

American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 3rd ed., revised. Washington, DC: American Psychiatric Association; 1987.Google Scholar
Barkow, KHeun, RÜstün, TBGänsicke, MMaier, WWittchen, U. Self-reported age-at-onset of selected psychiatric diagnoses in general health care: test-retest reliability and its determinants. Acta Psychiatrica Scand 2002;106:117–25.CrossRefGoogle Scholar
Boland, RJ. Depression in Alzheimer’s disease and other dementias. Curr Psychiatry Rep 2000;2:427–33.CrossRefGoogle ScholarPubMed
Buntinx, FKester, ABergers, JKnottnerus, JA. Is depression in elderly people followed by dementia? A retrospective cohort study in general practice. Age Ageing 1996;25:231–3.CrossRefGoogle ScholarPubMed
Cummings, JLRoss, WAbsher, JGornbein, JHadjiaghai, L. Depressive symptoms in Alzheimer disease: assessment and determinants. Alzheimer Dis Assoc Disord 1995;9:87–93.CrossRefGoogle ScholarPubMed
Cummings, JL. Cognitive and behavioral heterogeneity in Alzheimer’s disease: seeking the neurobiological basis. Neurobiol Aging 2000;21:845–61.CrossRefGoogle ScholarPubMed
Dufouil, CFuhrer, RDartigues, JFAlperovitch, A. Longitudinal analysis of the association between depressive symptomatology and cognitive deterioration. Am J Epidemiol 1996;144:634–41.CrossRefGoogle ScholarPubMed
Devanand, DPSano, MTang, MXTaylor, SGurland, BJWilder, DStern, YMayeux, R. Depressed mood and the incidence of Alzheimer’s disease in the elderly living in the community. Arch Gen Psychiatry 1996;53:175–82.CrossRefGoogle ScholarPubMed
Eaton, WWAnthony, JCGallo, JCai, GTien, ARomanoski, ALyketsos, CChen, LS. Natural history of Diagnostic Interview Schedule/DSM-IV major depression. The Baltimore Epide-miologic Catchment Area follow-up. Arch Gen Psychiatry 1997;54:993–9.CrossRefGoogle ScholarPubMed
Fahim, Svan Duijn, CMBaker, FMLauner, LBreteler, MMSchudel, WJHofman, A. A study of familial aggregation of depression, dementia and Parkinson’s disease. Eur J Epidemiol 1998;14:233–8.CrossRefGoogle ScholarPubMed
Förstl, HBurns, ALuthert, PCairns, NLantos, PLevy, R. Clinical and neuropathological correlates of depression in Alzheimer’s disease. Psychol Med 1992;22:877–84.CrossRefGoogle ScholarPubMed
Folstein, MFFolstein, SEMcHugh, PR. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–98.CrossRefGoogle Scholar
Geerlings, MISchoevers, RABeekman, ATJonker, CDeeg, DJSchmand, BAder, HJBouter, LMVan Tilburg, W. Depression and risk of cognitive decline and Alzheimer’s disease. Results of two prospective community-based studies in The Netherlands. Br J Psychiatry 2000;176:568–75.CrossRefGoogle ScholarPubMed
Harwood, DGBarker, WWOwnby, RLBravo, MAguero, HDuara, R. Depressive symptoms in Alzheimer’s disease. An examination among community-dwelling Cuban American patients. Am J Geriatr Psychiatry 2000;8:84–91.CrossRefGoogle ScholarPubMed
Heun, RMüller, HFreyberger, HJMaier, W. Reliability of interview information in a family study in the elderly. Social Psychiatry Psychiatric Epidemiol 1998;33:140–4.CrossRefGoogle Scholar
Heun, RPapassotiropoulos, AJessen, FMaier, WBreitner, JC. A family study of Alzheimer disease and early- and late-onset depression in elderly patients. Arch Gen Psychiatry 2001;58:190–6.CrossRefGoogle ScholarPubMed
Jorm, AF. Is depression a risk factor for dementia or cognitive decline? A review. Gerontology 2000;46:219–27.CrossRefGoogle ScholarPubMed
Migliorelli, RTeson, ASabe, LPetracchi, MLeiguarda, RStarkstein, SE. Prevalence and correlates of dysthymia and major depression among patients with Alzheimer’s disease. Am J Psychiatry 1995;152:37–44.Google ScholarPubMed
O’Brien, JThomas, ABallard, CBrown, AFerrier, NJaros, EPerry, R. Cognitive impairment in depression is not associated with neuropathologic evidence of increased vascular or Alzheimer-type pathology. Biol Psychiatry 2001;49:130–6.CrossRefGoogle ScholarPubMed
Simpson, SBaldwin, RCJackson, ABurns, AThomas, P. Is the clinical expression of late-life depression influenced by brain changes? MRI subcortical neuroanatomical correlates of depres-sive symptoms. Int Psychogeriatr 2000;12:425–34.CrossRefGoogle Scholar
Steffens, DCPlassman, BLHelms, MJWelsh-Bohmer, KASaunders, AMBreitner, JC. A twin study of late-onset depression and apolipoprotein E epsilon 4 as risk factors for Alzheimer’s disease. Biol Psychiatry 1997;41:851–6.CrossRefGoogle ScholarPubMed
Verhey, FRRozendaal, NPonds, RW. Dementia, awareness and depression. Int J Geriatr Psychiatry 1993;8:851–6.CrossRefGoogle Scholar
Videbech, PRavnkilde, BFiirgaard, BClemmensen, KEgander, ARasmussen, NAChristensen, TSangill, RRosenberg, R. Structural brain abnormalities in unselected in-patients with major depression. Acta Psychiatr Scand 2001;103:282–6.CrossRefGoogle ScholarPubMed
Wetherell, JLGatz, MJohansson, BPedersen, NL. History of depression and other psychiatric illness as risk factors for Alzheimer disease in a twin sample. Alzheimer Dis Assoc Disord 1999;13:47–52.CrossRefGoogle Scholar
Wittchen, HU. Reliability and validity studies of the WHO-Composite International Diagnostic Interview (CIDI): a critical review. J Psychiat Res 1994;28:57–84.CrossRefGoogle ScholarPubMed
World Health Organisation. Composite International Diagnostic Interview. Geneva, Switzerland: Division of Mental Health, World Health Organisation; 1990.Google Scholar
World Health Organization. Tenth revision of the international classification of diseases. Chapter V (F): Mental and behavioural disorders (including disorders of psychological development). Clinical Descriptions and Diagnostic Guidelines. Geneva: WHO; 1991.Google Scholar
Zaudig, MMittelhammer, JHiller, WPauls, AThora, C. Morinigo, AMombour, W. SIDAM—a structured interview for the diagnosis of dementia of the Alzheimer type, multi-infarct dementia and dementias of other aetiology according to ICD-10 and DSM-III-R. Psychol Med 1991;21:225–36.CrossRefGoogle Scholar
Zubenko, GSMoossy, J. Major depression in primary dementia. Clinical and neuropathologic correlates. Arch Neurol 1988;45:1182–6.CrossRefGoogle ScholarPubMed
Zubenko, GSMoossy, JKopp, U. Neurochemical correlates of major depression in primary dementia. Arch Neurol 1990;47:209–14.CrossRefGoogle ScholarPubMed
Zweig, RMRoss, CAHedreen, JCSteele, CCardillo, JEWhitehouse, PJFolstein, MFPrice, DL. The neuropathology of aminergic nuclei in Alzheimer’s disease. Ann Neurol 1988;24:233–42.CrossRefGoogle ScholarPubMed
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