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Diffusion tensor imaging in schizophrenia

Published online by Cambridge University Press:  16 April 2020

Marinos Kyriakopoulos ,
Theodoros Bargiotas ,
Gareth J. Barker  and
Sophia Frangou
Marinos Kyriakopoulos*
Affiliation:
Section of Neurobiology of Psychosis Institute of Psychiatry, King's College London, London, UK
Theodoros Bargiotas
Affiliation:
Section of Neurobiology of Psychosis Institute of Psychiatry, King's College London, London, UK
Gareth J. Barker
Affiliation:
Department of Clinical Neuroscience, Centre for Neuroimaging Sciences, Institute of Psychiatry, King's College London, London, UK
Sophia Frangou
Affiliation:
Section of Neurobiology of Psychosis Institute of Psychiatry, King's College London, London, UK
*
∗Corresponding author. Tel.: +44 20 78480425. E-mail address: m.kyriakopoulos@iop.kcl.ac.uk (M. Kyriakopoulos).
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Abstract

Diffusion tensor imaging (DTI) is a magnetic resonance imaging technique that is increasingly being used for the non-invasive evaluation of brain white matter abnormalities. In this review, we discuss the basic principles of DTI, its roots and the contribution of European centres in its development, and we review the findings from DTI studies in schizophrenia. We searched EMBASE, PubMed, PsychInfo, and Medline from February 1998 to December 2006 using as keywords ‘schizophrenia’, ‘diffusion’, ‘tensor’, and ‘DTI’. Forty studies fulfilling the inclusion criteria of this review were included and systematically reviewed. White matter abnormalities in many diverse brain regions were identified in schizophrenia. Although the findings are not completely consistent, frontal and temporal white matter seems to be more commonly affected. Limitations and future directions of this method are discussed.

Keywords

SchizophreniaDiffusion tensor imagingWhite matterAnisotropyTractography
Type
Original article
Information
European Psychiatry , Volume 23 , Issue 4 , June 2008 , pp. 255 - 273
Copyright
Copyright © European Psychiatric Association 2008

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