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Disrupted homeostasis during chronic ethanol consumption associated with specific mechanism of endogenous neurosteroids activity

Published online by Cambridge University Press:  23 March 2020

T. Shushpanova ,
N. Bokhan ,
A. Mandel ,
A. Solonsky ,
T. Novozheeva ,
A. Semke ,
V. Lebedeva ,
T. Kazennykh ,
V. Udut  and
G. Arbit
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T. Shushpanova*
Affiliation:
Mental Health Research Institute, Biological Psychiatry Department, Tomsk, Russia
N. Bokhan
Affiliation:
Mental Health Research Institute, Addictive States Department, Tomsk, Russia
A. Mandel
Affiliation:
Mental Health Research Institute, Addictive States Department, Tomsk, Russia
A. Solonsky
Affiliation:
Mental Health Research Institute, Biological Psychiatry Department, Tomsk, Russia
T. Novozheeva
Affiliation:
Mental Health Research Institute, Biological Psychiatry Department, Tomsk, Russia
A. Semke
Affiliation:
Mental Health Research Institute, Endogenous Disorders Department, Tomsk, Russia
V. Lebedeva
Affiliation:
Mental Health Research Institute, Clinics, Tomsk, Russia
T. Kazennykh
Affiliation:
Mental Health Research Institute, Scientific secretary, Tomsk, Russia
V. Udut
Affiliation:
Pharmacology and Regenerative Medicine Research Institute, Tomsk, Russia
G. Arbit
Affiliation:
National Research Tomsk Polytechnic University, Biotechnology and Organic Chemistry Department, Tomsk, Russia
V. Philimonov
Affiliation:
National Research Tomsk Polytechnic University, Biotechnology and Organic Chemistry Department, Tomsk, Russia
E. Markova
Affiliation:
Basic and Clinical Immunology Institute, Laboratory of Neuroimmunology, Novosibirsk, Russia
*
* Corresponding author.

Abstract

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Introduction

Neurobiological research describes one of mechanisms overlap in the Cortico-Striatal-Limbic Circuit (CSLC), which can be disrupted due to chronic stress and alcohol abuse that primarily modulated by the hypothalamic-pituitary-adrenal (HPA) axis, from which cortisol is an end-product.

Objectives

To investigate the effects of chronic stimulant abuse on the CSLC. This was examined by relating cortisol levels with grey matter volume in brain structures associated with addiction and stress.

Aims

We hypothesized that stimulant-dependent individuals show increased cortisol levels and abnormalities in the CSLC. We further hypothesized relationships between altered grey matter volume and increased cortisol levels in the patients.

Methods

Twenty-two alcohol-dependent individuals, men only and 21 healthy volunteers (matched for age and gender) underwent an assessment session. Cortisol, DHEA and DHEA-S was assessed in blood plasma. Mood, impulsivity and compulsivity were measured by clinical instruments.

Results

Alcohol-dependent individuals showed higher levels of cortisol in blood plasma, and decreased levels of progesterone and its metabolites DHEA and DHEA-S, which were associated with distinct expression in impulsivity and compulsivity in alcoholic patients. Indices of these steroids were changed compared with healthy persons. Plasma cortisol was positively correlated with the duration of alcohol use. The relationships observed between cortisol, progesterone and its metabolites: DHEA and DHEA-S may be explained by abnormal functioning of HPA axis.

Conclusions

Optimizing of disrupted homeostasis during chronic ethanol consumption being provided with specific mechanism by manipulation of endogenous neurosteroids activity may prove a beneficial pharmacotherapeutic strategy in the intervention of alcohol abuse.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EV98
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S317
Copyright
Copyright © European Psychiatric Association 2016
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