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Do psychosis prodrome onset negative symptoms predict first presentation negative symptoms?

Published online by Cambridge University Press:  15 April 2020

J. Lyne ,
L. Renwick ,
K. Madigan ,
B. O’Donoghue ,
M. Bonar ,
T. Grant ,
A. Kinsella ,
K. Malone ,
N. Turner  and
E. O’Callaghan
...Show all authors
J. Lyne*
Affiliation:
Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock Co., Dublin, Ireland College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland
L. Renwick
Affiliation:
Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock Co., Dublin, Ireland College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland
K. Madigan
Affiliation:
Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock Co., Dublin, Ireland
B. O’Donoghue
Affiliation:
Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock Co., Dublin, Ireland College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland
M. Bonar
Affiliation:
Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock Co., Dublin, Ireland
T. Grant
Affiliation:
Centre for Support and Training in Analysis and Research (CSTAR), University College Dublin, Belfield, Dublin 4, Ireland
A. Kinsella
Affiliation:
Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock Co., Dublin, Ireland
K. Malone
Affiliation:
Department of Psychiatry, Psychotherapy and Mental Health Research, St. Vincent's University Hospital / School of Medicine and Medical Science, University College Dublin, Elm Park, Dublin 4, Ireland
N. Turner
Affiliation:
Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock Co., Dublin, Ireland
E. O’Callaghan
Affiliation:
Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock Co., Dublin, Ireland School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland St. John of God Community Services Ltd., Blackrock, Co., Dublin, Ireland
M. Clarke
Affiliation:
Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock Co., Dublin, Ireland School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland St. John of God Community Services Ltd., Blackrock, Co., Dublin, Ireland
*
*Corresponding author. DETECT Services, Avila House, Block 5, Blackrock Business Park, Blackrock Co., Dublin, Ireland. Tel.: +353 1 2791700; fax: +353 1 2791799. E-mail address: johnlyne@mail.com (J. Lyne).
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Abstract

Background:

Negative symptoms have been previously reported during the psychosis prodrome, however our understanding of their relationship with treatment-phase negative symptoms remains unclear.

Objectives:

We report the prevalence of psychosis prodrome onset negative symptoms (PONS) and ascertain whether these predict negative symptoms at first presentation for treatment.

Methods:

Presence of expressivity or experiential negative symptom domains was established at first presentation for treatment using the Scale for Assessment of Negative Symptoms (SANS) in 373 individuals with a first episode psychosis. PONS were established using the Beiser Scale. The relationship between PONS and negative symptoms at first presentation was ascertained and regression analyses determined the relationship independent of confounding.

Results:

PONS prevalence was 50.3% in the schizophrenia spectrum group (n = 155) and 31.2% in the non-schizophrenia spectrum group (n = 218). In the schizophrenia spectrum group, PONS had a significant unadjusted (χ2 = 10.41, P < 0.001) and adjusted (OR = 2.40, 95% CI = 1.11–5.22, P = 0.027) association with first presentation experiential symptoms, however this relationship was not evident in the non-schizophrenia spectrum group. PONS did not predict expressivity symptoms in either diagnostic group.

Conclusion:

PONS are common in schizophrenia spectrum diagnoses, and predict experiential symptoms at first presentation. Further prospective research is needed to examine whether negative symptoms commence during the psychosis prodrome.

Keywords

SchizophreniaPsychosis prodromeNegative symptomsExpressivityExperiential
Type
Original article
Information
European Psychiatry , Volume 29 , Issue 3 , March 2014 , pp. 153 - 159
Copyright
Copyright © European Psychiatric Association 2014

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Footnotes

†

Deceased author.

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