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Does insomnia increase the risk of suicide in patients with major depressive disorders? national inpatient sample analysis

Published online by Cambridge University Press:  13 August 2021

A. Reddy ,
Z. Mansuri ,
R. Vadukapuram ,
M. Thootkur  and
C. Trivedi
A. Reddy*
Affiliation:
Psychiatry, Virginia Tech Carilion School of Medicine, Roanoke, United States of America
Z. Mansuri
Affiliation:
Department Of Psychiatry, Boston Children’s Hospital/Harvard Medical School, Boston, United States of America
R. Vadukapuram
Affiliation:
Psychiatry, Icahn School of Medicine at Mount Sinai, New York, United States of America
M. Thootkur
Affiliation:
Psychiatry, Virginia Tech Carilion School of Medicine, Roanoke, United States of America
C. Trivedi
Affiliation:
Research, St Davids Healthcare, Austin, United States of America
*
*Corresponding author.

Abstract

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Introduction

Insomnia is strongly associated with Major depressive disorders (MDD). There is strong evidence that it is one of the risk factor for suicide. Studies have shown the relationship of suicidal behavior in MDD patients with insomnia. However, it has not been evaluated in a large inpatient sample.

Objectives

To evaluate suicidality in MDD patients with insomnia compared to those without insomnia.

Methods

From the National Inpatient Sample (NIS 2006-2015) database using ICD-9 code, we obtained patients with the primary diagnosis of MDD and comorbid diagnosis of insomnia disorders (MDD+S). We compared it with MDD patients without insomnia disorders (MDD-S) by performing a 1:2 match for primary diagnosis code in the unweighted dataset. Suicidal ideation/attempt data were compared between the groups by multivariate logistic regression analysis.

Results

After the diagnostic code matching, 139061 patients were included in the MDD+S group and 276496 patients in the MDD- S group. MDD+S patients were older (47 years vs 45 years, p < 0.001) compared to the MDD-S group. Prevalence of Suicidal ideation/attempt was 56.0% in the MDD+S group and 42.0% in the MDD-S group (p < 0.001). After adjusting for age, sex, and race, MDD+S was associated with 1.8 times higher odds of suicidal behavior compared to the MDD-S group. (Odds ratio: 1.79, 95% confidence interval 1.68-1.91, p < 0.001).

Conclusions

Insomnia in MDD patients is significantly associated with the risk of suicide. It is important to be watchful for insomnia in MDD patients.

Disclosure

No significant relationships.

Keywords

InsomniaDepressionSuicidemood disorders
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S170 - S171
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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