Hostname: page-component-cd9895bd7-mkpzs Total loading time: 0 Render date: 2024-12-25T19:30:26.707Z Has data issue: false hasContentIssue false
  • English
  • Français

The dopamine D2 receptor gene TaqI A polymorphism is not associated with Novelty Seeking, Harm Avoidance and Reward Dependence in healthy subjects

Published online by Cambridge University Press:  16 April 2020

B de Brettes ,
I Berlin ,
C Laurent ,
JP Lépine ,
J Mallet  and
AJ Puech
B de Brettes
Affiliation:
Service de Pharmacologie, Hôpital Pitié-Salpêtrière, 47, Boulevard de l'Hôpital, 75013Paris
I Berlin*
Affiliation:
Service de Pharmacologie, Hôpital Pitié-Salpêtrière, 47, Boulevard de l'Hôpital, 75013Paris
C Laurent
Affiliation:
Laboratoire de Génétique moléculaire de la Neurotransmission et des Processus Neurodégénératifs C 9923 CNRS, Hôpital Pitié-Salpêtrière
JP Lépine
Affiliation:
Service de Psychiatrie, Hôpital Fernand Widal, Paris, France
J Mallet
Affiliation:
Laboratoire de Génétique moléculaire de la Neurotransmission et des Processus Neurodégénératifs C 9923 CNRS, Hôpital Pitié-Salpêtrière
AJ Puech
Affiliation:
Service de Pharmacologie, Hôpital Pitié-Salpêtrière, 47, Boulevard de l'Hôpital, 75013Paris
*
*Correspondence and reprints.
Get access

Summary

Allele A1 of the TaqI A restriction fragment length polymorphism (RFLP) of the dopamine D2 receptor gene has been found to be associated with substance abuse and alcoholism. The personality trait of Novelty Seeking (NS) is also associated with substance abuse and dependence. We hypothesised, on the basis of involvement of dopaminergic mechanisms in substance abuse, that the presence of allele A1 of the dopamine D2 receptor gene may represent a genetic predisposition for the NS personality trait. We investigated, therefore, whether the allele A1 of the TaqI A RFLP of the dopamine D2 receptor gene is associated with the NS dimension of the Tridimensional Personality Questionnaire (TPQ) in healthy Caucasian subjects with no history of alcohol or substance abuse or dependence. We genotyped 204 subjects aged 18 to 30 years. There was no association between any of the alleles of the D2 receptor genes and any of the TPQ scores (NS, Harm Avoidance, Reward Dependence). We conclude that allele A1 of the TaqI A RFLP of the dopamine D2 receptor is not associated with NS personality trait in healthy Caucasian subjects.

Keywords

personality traitsgenotypedopamine D2 receptor
Type
Short communication
Information
European Psychiatry , Volume 13 , Issue 8 , December 1998 , pp. 427 - 430
Copyright
Copyright © Elsevier, Paris 1998

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Altman, JEveritt, BJGlautier, SMarkou, ANutt, DOretti, Ret al.The biological, social and clinical bases of drug addiction: commentary and debate Psychopharmacolagy 1996; 125: 285–345CrossRefGoogle ScholarPubMed
Amadéo, SAbbar, MFourcade, MLWaksman, GLeroux, MGMadec, Aet al.D2 dopamine receptor gene and alcoholism J Psychiat Res 1993; 2: 173–179CrossRefGoogle Scholar
American Psychiatric Association, Diagnostic and statistical manual of mental disorders. DSM-IV 1994Google Scholar
Balldin, JIBerggren, UCLindstedt, GNeuroendocrine evidence for reduced dopamine receptor sensitivity in alcoholism Alcoholism Clin Exp Res 1992; 16: 71–74CrossRefGoogle ScholarPubMed
Benjamin, JLi, LPatterson, CGreenberg, BDMurphy, DLHamer, DHPopulation and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking Nature Genet 1996; 12: 81–84CrossRefGoogle ScholarPubMed
Blum, KNoble, EPSheridan, PJFinley, OMontgomery, ARitchie, Tet al.Allelic association of human dopamine D2 receptor gene in alcoholism JAMA 1990; 263: 2055–2060CrossRefGoogle ScholarPubMed
Cloninger, CRA systematic method for clinical description and classification of personality variants Arch Gen Psychiatry 1987; 44: 573–588CrossRefGoogle ScholarPubMed
Cloninger, CRPrzybec, TRSvrakic, DMThe Tridimensional Personality Questionnaire: US normative data Psychological Reports 1991; 69: 1047–1057CrossRefGoogle Scholar
Compton, PAAnglin, MDKhalsa-Denison, EParedes, AThe D2 dopamine receptor gene, addiction, and personality: clinical correlates in cocaine abusers Biol Psychiatry 1996; 39: 302–304CrossRefGoogle ScholarPubMed
Ebstein, RBNovick, OUmansky, RPriel, BOsher, YBaline, Det al.Dopamine D4 receptor (D4DR) polymorphism associated with the human personality trait of Novelty seeking Nature Genet 1996; 12: 78–80CrossRefGoogle ScholarPubMed
Farde, LGustavsson, JPJönsson, ED2 dopamine receptors and personality traits Nature 1997; 385: 590CrossRefGoogle ScholarPubMed
Farré, MLamas, XCami, JSensation seeking amongst healthy volunteers participating in phase I clinical trials Brit J Clin Pharmacol 1995; 39: 405–409CrossRefGoogle ScholarPubMed
Gelernter, JGoldman, DRisch, NThe A1 allele at the D2 dopamine receptor gene and alcoholism JAMA 1993; 269: 1673–1677CrossRefGoogle ScholarPubMed
Grandy, DKZhang, YCivelli, OPCR detection of the TaqA RFLP at the DRD2 locus Hum Mol Genet 1993; 2: 2197CrossRefGoogle ScholarPubMed
Jönsson, EGNöthen, MMGustavsson, JPNeidt, HBerné, STylec, Aet al.Lack of evidence for allelic association between personality traits and the dopamine D4 receptor gene polymorphism Am J Psychiatry 1997; 154: 697–699Google Scholar
Lépine, JPPelissolo, ATéodorescu, RTéhérani, MEvaluation des propriétés psychométriques de la version française du questionnaire tridimensionnel de la personnalité (TPQ) L'Encéphale XX 1994 747–753Google Scholar
Malhotra, AKVirkkunen, MRooney, WEggert, MLinnoila, MGoldman, DThe association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and Novelty Seeking Mol Psychiatry 1996; 1: 388–391Google ScholarPubMed
Noble, EPBlum, KRitchie, TMontgomery, ASheridan, PJAllelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism Arch Gen Psychiatry 1991; 48: 648–654CrossRefGoogle ScholarPubMed
O'Hara, BFSmith, SSBird, GPersico, AMSuarez, BKCutting, GRet al.Dopamine D2 receptor RFLPs, haplotypes and their association with substance use in black and Caucasian research volunteers Hum Hered 1993; 43: 209–218CrossRefGoogle ScholarPubMed
Ono, YManki, HYoshimura, KMuramatsu, TMizushima, HHiguchi, Set al.Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects Am J Med Genet 1997; 74: 501–5033.0.CO;2-Q>CrossRefGoogle ScholarPubMed
Smith, SSO'Hara, BFPersico, AMGorelick, DANewlin, DBVlahov, Det al.Genetic vulnerability to drug abuse. The D2 dopamine receptor Taq I B1 restriction fragment length polymorphism appears more frequently in polysubstance abusers Arch Gen Psychiatry 1992; 49: 723–727CrossRefGoogle ScholarPubMed
Stallings, MCHewitt, JKCloninger, CRHeath, ACEaves, LJGenetic and environmental structure of the Tridimensional Personality Questionnaire: three or four temperament dimensions? J Personality Soc Psychol 1996; 70: 127–140CrossRefGoogle ScholarPubMed
Vandenbergh, DJZonderman, ABWang, JUhl, GRCosta, PTNo association between Novelty Seeking and dopamine D4 receptor (D4DR) exon III seven repeat alleles in Baltimore Longitudinal Study of Ageing participants Mol Psychiatry 1997; 2: 417–419CrossRefGoogle Scholar
Submit a response

Comments

No Comments have been published for this article.