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Drug disposition and switch process: an attractive hypothesis

Published online by Cambridge University Press:  16 April 2020

M Toutoungi  and
J Richard
M Toutoungi
Affiliation:
Department of Psychiatry of the University of Geneva, 10 Chemin du Petit Bel-Air, CH-1225, Chêne Bourg
J Richard
Affiliation:
Department of Geriatric Psychiatry of the University of Geneva, 10 Chemin du Petit Bel-Air, CH-1225, Chêne Bourg, Switzerland
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Summary

Two cases of bipolar psychosis presented a rapid manic switch following administration of tricyclic antidepressants. In both cases the oxidation capacity was genetically deficient. The role of oxidation deficit is discussed in the pathogenesis of switch process and preventive measures are considered.

Keywords

imipramineclomipramineswitch processoxidation polymorphism
Type
Original article
Information
European Psychiatry , Volume 6 , Issue 1 , 1991 , pp. 53 - 55
Copyright
Copyright © Elsevier, Paris 1991

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