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Early reduction in prefrontal theta QEEG cordance value predicts response to venlafaxine treatment in patients with resistant depressive disorder

Published online by Cambridge University Press:  16 April 2020

Martin Bares ,
Martin Brunovsky ,
Miloslav Kopecek ,
Tomas Novak ,
Pavla Stopkova ,
Jiri Kozeny ,
Peter Sos ,
Vladimir Krajca  and
Cyril Höschl
Martin Bares*
Affiliation:
Prague Psychiatric Centre, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic Department of Psychiatry and Medical Psychology, 3rd Faculty of Medicine, Charles University, Ruska 87, 100 00 Prague 10, Czech Republic
Martin Brunovsky
Affiliation:
Prague Psychiatric Centre, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic Department of Psychiatry and Medical Psychology, 3rd Faculty of Medicine, Charles University, Ruska 87, 100 00 Prague 10, Czech Republic
Miloslav Kopecek
Affiliation:
Prague Psychiatric Centre, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic Department of Psychiatry and Medical Psychology, 3rd Faculty of Medicine, Charles University, Ruska 87, 100 00 Prague 10, Czech Republic Center of Excellence for Research and Treatment Bipolar Disorder, Department of Psychiatry, University of North Carolina at Chapel Hill, NC, USA
Tomas Novak
Affiliation:
Prague Psychiatric Centre, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic Department of Psychiatry and Medical Psychology, 3rd Faculty of Medicine, Charles University, Ruska 87, 100 00 Prague 10, Czech Republic
Pavla Stopkova
Affiliation:
Prague Psychiatric Centre, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic Department of Psychiatry and Medical Psychology, 3rd Faculty of Medicine, Charles University, Ruska 87, 100 00 Prague 10, Czech Republic
Jiri Kozeny
Affiliation:
Prague Psychiatric Centre, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic Department of Psychiatry and Medical Psychology, 3rd Faculty of Medicine, Charles University, Ruska 87, 100 00 Prague 10, Czech Republic
Peter Sos
Affiliation:
Prague Psychiatric Centre, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic Department of Psychiatry and Medical Psychology, 3rd Faculty of Medicine, Charles University, Ruska 87, 100 00 Prague 10, Czech Republic
Vladimir Krajca
Affiliation:
Department of Neurology, Faculty Hospital Na Bulovce, 180 00Prague 8, Czech Republic
Cyril Höschl
Affiliation:
Prague Psychiatric Centre, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic Department of Psychiatry and Medical Psychology, 3rd Faculty of Medicine, Charles University, Ruska 87, 100 00 Prague 10, Czech Republic
*
*Corresponding author. Prague Psychiatric Centre, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic. Tel.: +420 266 003 330; fax: +420 266 003 337. E-mail address: bares@pcp.lf3.cuni.cz (M. Bares).
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Abstract

Introduction

Previous studies of patients with unipolar depression have shown that early decrease of prefrontal EEG cordance in theta band can predict clinical response to various antidepressants. We have now examined whether decrease of prefrontal quantitative EEG (QEEG) cordance value after 1 week of venlafaxine treatment predicts clinical response to venlafaxine in resistant patients.

Method

We analyzed 25 inpatients who finished 4-week venlafaxine treatment. EEG data were monitored at baseline and after 1 week of treatment. QEEG cordance was computed at three frontal electrodes in theta frequency band. Depressive symptoms and clinical status were assessed using Montgomery–Åsberg Depression Rating Scale (MADRS), Beck Depression Inventory-Short Form (BDI-S) and Clinical Global Impression (CGI).

Results

Eleven of 12 responders (reduction of MADRS ≥50%) and only 5 of 13 non-responders had decreased prefrontal QEEG cordance value after the first week of treatment (p = 0.01). The decrease of prefrontal cordance after week 1 in responders was significant (p = 0.03) and there was no significant change in non-responders. Positive and negative predictive values of cordance reduction for response were 0.7 and 0.9, respectively.

Conclusion

The reduction of prefrontal theta QEEG cordance value after first week of treatment might be helpful in the prediction of response to venlafaxine.

Keywords

VenlafaxineDepressive disorderResistant depressionCordanceQEEGResponse prediction
Type
Original article
Information
European Psychiatry , Volume 23 , Issue 5 , August 2008 , pp. 350 - 355
Copyright
Copyright © Elsevier Masson SAS 2008

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