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Effects of tianeptine on behavioural and neurochemical responses to immobilization stress

Published online by Cambridge University Press:  16 April 2020

G Curzon  and
KP Datla
G Curzon
Affiliation:
Department of Neurochemistry, Institute of Neurology, 1 Wakefield Street, London, WCIN IPJ, UK
KP Datla
Affiliation:
Department of Neurochemistry, Institute of Neurology, 1 Wakefield Street, London, WCIN IPJ, UK
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Summary

The novel antidepressant drug tianeptine had an antidepressant-like effect on a rat model of depression based on the deficit in open field activity observed on the day after 2 h immobilization. Thus, tianeptine (10 mg/kg ip) given 2 h after the end of the immobilization period led to the deficit being opposed. Similar results were obtained using rats previously given 10 mg/kg of the drug per day for 13 days and a final dose 2 h after the end of immobilization. Other workers have found that tianeptine attenuates stress-induced activation of the hypothalamo-pituitary-adrenal axis. Possible relationships between these findings are discussed together with the paradoxical co-existence of the antidepressant properties of tianeptine with its ability to decrease the availability of 5-HT to receptors.

Keywords

antidepressant drugscorticosteronedepression5-HTtianeptine
Type
Research Article
Information
European Psychiatry , Volume 8 , Issue S2: Neuroendocrinological aspects of depression 28 June 1992, Nice, France , 1993 , pp. 61s - 66s
Copyright
Copyright © Elsevier, Paris 1993

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References

Armario, AGarcia-Marquez, C (1987) Tricyclic antidepressants activate the pituitary-adrenal axis in the rat. Tolerance to repeated drug administration. Eur J Pharmacol 140,239–244CrossRefGoogle ScholarPubMed
Berendsen, HHGBroekkamp, CLE (1991) Attenuation of 5-HT1A and 5-HT2 but not 5-HT1C receptor mediated behaviour in rats following chronic treatment with 5-HT receptor agonists, antagonists or anti-depressants. Psychopharmacology 105, 219–224CrossRefGoogle ScholarPubMed
Broqua, PBaudrie, VLaude, DChaouloff, F (1992) Influence of the novel antidepressant tianeptine on neurochemical, neuroendocrinological and behavioural effects of stress in rats. Biol Psychiatry 33, 391–401CrossRefGoogle Scholar
Brunello, NRiva, MVolterra, ARacagni, G (1987) Effect of some tricyclic and non tricyclic antidepressants on [3H] imipramine binding and serotonin uptake in rat cerebral cortex after prolonged treatment. Fundam Clin Pharmacol 1, 327–333CrossRefGoogle Scholar
Chamba, GLemoine, PFlachaire, EFerry, NQuincy, CSassard, JFerber, CMocaer, EKamoun, ARenaud, B (1991) Increased serotonin platelet uptake after tianeptine administration in depressed patients. Biol Psychiatry 30, 609–617CrossRefGoogle ScholarPubMed
Chapuy, PCuny, GDelormier, YGalley, PMichel, J-PPareaud, MMarey, C (1991) La dépression du sujet âgé. Intérêt de la tianeptine chez 140 patients traités pendant 1 an. Presse Méd 20, 1844–1852Google Scholar
Checkley, S (1992) Neuroendocrine mechanisms and the precipitation of depression by life events. Br J Psychiatry 160 (suppl 15), 7–17CrossRefGoogle Scholar
Curzon, GFernando, JCRMarsden, CA (1978) 5-Hydroxytryptamine: effect of impaired synthesis on its metabolism and release in rat. Br J Pharmacol 63, 627–634CrossRefGoogle Scholar
Curzon, GKennett, GASarna, GSWhitton, PS (1992) The effects of tianeptine and other antidepressants on a rat model of depression. Br J Psychiatry 160 (Suppl 15), 50–54CrossRefGoogle Scholar
Delbende, CContesse, VMocaer, EVaudry, H (1991) The novel antidepressant tianeptine reduces stress-evoked stimulation of the HPA axis. Eur J Pharmacol 202,391–396CrossRefGoogle Scholar
Delbende, CMocaer, EGrino, MOliver, CVaudry, H (1993) Effect of tianeptine on stress-induced activation of the hypothalamo-pituitary adrenal axis. Eur Psychiatry 8, 49–54Google Scholar
Delgado, PLCharney, DSPrice, HLAghajanian, GKLandis, HHeninger, GR (1990) Serotonin function and the mechanism of antidepressant action: reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Arch Gen Psychiatry 47, 411–418CrossRefGoogle ScholarPubMed
Dickinson, SLKennett, GACurzon, G (1985) Reduced 5-hydroxytryptamine dependent behaviour in rats following chronic corticosterone treatment. Brain Res 345, 10–18CrossRefGoogle ScholarPubMed
Dresse, AScuvee-Moreau, J (1988) Electrophysiological effects of tianeptine on rat locus coeruleus, raphe dorsalis, and hippocampal activity. Clin Neuropharmacol 11 (suppl 2), S51–S53Google Scholar
Fattaccini, CMBolanos-Jimenez, FGozlan, HHamon, M (1990) Tianeptine stimulates uptake of 5-hydroxytryptamine in vivo in the rat brain. Neuropharmacology 29, 1–18CrossRefGoogle ScholarPubMed
Feldman, SConforti, NMelamed, E (1987) Paraventricular nucleus serotonin mediates neurally stimulated adrenocortical secretion. Brain Pes Bull 18, 165–168CrossRefGoogle ScholarPubMed
Guelfi, JD (1992) Efficacy of tianeptine in comparative trials versus reference antidepressants. Br J Psychiatry 160 (suppl 15), 72–75CrossRefGoogle Scholar
Guillaume, VMagnan, ECataldi, Met al (1993) Effect of tianeptine on the hypothalamic control of the corticotropic response to stress. Eur Psy (suppl 2) 8, 55s–60sGoogle Scholar
Haleem, DJKennett, GACurzon, G (1988) Adaptation of female rats to stress: shift to male pattern by inhibition of cortiocosterone synthesis. Brain Res 458, 339–347CrossRefGoogle Scholar
Haleem, DJKennett, GAWhitton, PSCurzon, G (1989) 8-OH-DPAT increases corticosterone but not other 5- HT1A receptor-dependent responses more in females. Eur J Pharmacol 164, 435–143CrossRefGoogle ScholarPubMed
Heninger, GRCharney, DSSternberg, DE (1984) Serotonin function in depression: prolactin response to intravenous tryptophan in depressed patients and healthy subjects. Arch Gen Psychiatry 41, 398–402CrossRefGoogle ScholarPubMed
Invernizzi, RPozzi, LGarattini, SSamanin, R (1992) Tianeptine increases the extracellular concentration of dopamine in the nucleus accumbens by a serotoninindependent mechanism. Neuropharmacology 31, 221–227CrossRefGoogle Scholar
Kato, GWeitsch, AF (1988) Neurochemical profile of tianeptine, a new antidepressant drug. Clin Neuropharmacology 11 (suppl 2), S43–S50Google ScholarPubMed
Kelly, JPLeonard, BE (1991) The effect of tianeptine and sertraline on the olfactory bulbectomized rat model of depression. Neuropharmacology (submitted for publication)Google Scholar
Kennett, GADickinson, SLCurzon, G (1985a) Enhancement of some 5-HT-dependent behavioural responses following repeated immobilisation in rats. Brain Res 330, 253–263CrossRefGoogle Scholar
Kennett, GADickinson, SLCurzon, G (1985b) Central serotonergic responses and behavioural adaptation to repeated immobilisation: the effect of the corticosterone synthesis inhibitor metyrapone. Eur J Pharmacol 119, 143–152CrossRefGoogle Scholar
Kennett, GAChaouloff, FMarcou, MCurzon, G (1986) Female rats are more vulnerable than males in an animal model of depression: the possible role of serotonin. Brain Res 382, 416–421CrossRefGoogle Scholar
Kennett, GADourish, CTCurzon, G (1987) Antidepressant-like action of 5-HT agonists and conventional antidepressants in an animal model of depression. Eur J Pharmacol 134, 265–274CrossRefGoogle Scholar
Koshikawa, NMocaer, EStephenson, JD (1991) The effect of tianeptine on wet-dog shakes, forepaw treading and a flexor reflex in rats are consistent with enhancement of 5-hydroxytryptamine uptake. Eur J Pharmacol 198, 51–57CrossRefGoogle Scholar
Labrid, CMoleyre, JPoignant, JCMalen, CMocaer, EKamoun, A (1988) Structure-activity relationships of tricyclic antidepressants, with special reference to tianeptine. Clin Neuropharmacol 11 (suppl 1), S21–S31Google ScholarPubMed
Louilot, AMocaer, ESimon, HLe Moal, M (1990) Differences in the effects of the antidepressant tianeptine on dopaminergic metabolism in the prefrontal cortex and the nucleus accumbens of the rat. A voltammetric study. Life Sci 47, 1083–1089CrossRefGoogle Scholar
Mennini, TGarattini, S (1991) Neurobiologie de la tianeptine: un nouveau réactif pharmacologique. Presse Méd 20, 1823–1827Google Scholar
Mennini, TMocaer, EGarattini, S (1987) Tianeptine, a selective enhancer of serotonin uptake in rat brain. Naunyn-Schmiedeberg's Arch Pharmacol 336, 478–482CrossRefGoogle ScholarPubMed
Muscat, RPapp, MWillner, P (1992) Antidepressant like actions of dopamine agonists in an animal model of depression. Biol Psychiatry 937–946CrossRefGoogle Scholar
Nemeroff, CB (1988) The role of corticotrophin-releasing factor in the pathogenesis of major depression. Pharmacopsychiatry 21, 76–82CrossRefGoogle ScholarPubMed
O'Connell, MTPortas, CMSarna, GSCurzon, G (1991) Effect of p-chlorophenylalanine on release of 5-hydroxytryptamine from the rat frontal cortex in vivo. Br J Pharmacol 102, 831–836CrossRefGoogle ScholarPubMed
Ortiz, JMocaer, EArtigas, F (1991) Effects of the antidepressant drug tianeptine on plasma and platelet serotonin concentrations in the rat. Eur J Pharmacol 199,335–339CrossRefGoogle ScholarPubMed
Shimizu, NTake, SHori, TOomura, Y (1992) In vivo measurement of hypothalamic serotonin release by intracerebral microdialysis: significant enhancement by immobilization stress in rats. Brain Res Bull 28, 727–734CrossRefGoogle ScholarPubMed
Shopshin, BFriedman, EGershon, S (1976) Parachlorophenylalanine reversal of tranylcypromine effects in depressed patients. Arch Gen Psychiatry 33, 811–819CrossRefGoogle Scholar
Weissman, MMLeaf, PJHolzer, CEMyers, KTischler, GL (1984) The epidemiology of depression. An update on sex differences in rats. J Affect Dis 7, 179–188CrossRefGoogle Scholar
Whitton, PSSarna, GSDatla, KPCurzon, G (1991a) Effects of tianeptine on stress-induced behavioural deficits and 5-HT dependent behaviour. Psychopharmacology 104, 81–85CrossRefGoogle Scholar
Whitton, PSSarna, GSO'Connell, MTCurzon, G (1991b) The effect of the novel antidepressant tianeptine on the concentration of 5-hydroxytryptamine in rat hippocampal dialysates in vivo. Neuropharmacology 30, 1–4CrossRefGoogle Scholar
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