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Efficacy of lithium treatment in Kleine–Levin syndrome

Published online by Cambridge University Press:  16 April 2020

F. Muratori ,
N. Bertini  and
G. Masi
F. Muratori*
Affiliation:
Division of Child Neurology and Psychiatry, University of Pisa (Italy), IRCCS Stella Maris, Via dei Giacinti 2, 56018 Calambrone (Pi), Pisa, Italy
N. Bertini
Affiliation:
Division of Child Neurology and Psychiatry, University of Pisa (Italy), IRCCS Stella Maris, Via dei Giacinti 2, 56018 Calambrone (Pi), Pisa, Italy
G. Masi
Affiliation:
Division of Child Neurology and Psychiatry, University of Pisa (Italy), IRCCS Stella Maris, Via dei Giacinti 2, 56018 Calambrone (Pi), Pisa, Italy
*
*Corresponding author. E-mail address: fmuratori@inpe.unipi.it (F. Muratori).
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Summary

The Kleine–Levin syndrome (KLS) is characterized by periodic, sudden-onset episodes of hypersomnia, compulsive hyperphagia, and behavioral–emotional symptoms, lasting from a few days to a few weeks, with complete remission in the intercritical periods. We report on efficacy of lithium treatment in a highly recurring form of the disorder in a 17-year-old male adolescent. The decreasing severity of the disorder paralleled the progressive increase of lithium dosage, up to 0.9 mEq l–1. Implications regarding the pharmacological treatment of this neglected disorder are discussed.

Keywords

Kleine-Levin syndromeLithiumAdolescence
Type
Case Reports
Information
European Psychiatry , Volume 17 , Issue 4 , July 2002 , pp. 232 - 233
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2002

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