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Electroconvulsive therapy in the treatment of mixed states in bipolar disorder

Published online by Cambridge University Press:  16 April 2020

Marc Valentí ,
Antoni Benabarre ,
Margarita García-Amador ,
Oriol Molina ,
Miquel Bernardo  and
Eduard Vieta
Marc Valentí
Affiliation:
Bipolar Disorders Program, Institute of Clinical Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBER-SAM, Villarroel 170/Rossello 140, 08036Barcelona, Catalonia, Spain
Antoni Benabarre
Affiliation:
Bipolar Disorders Program, Institute of Clinical Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBER-SAM, Villarroel 170/Rossello 140, 08036Barcelona, Catalonia, Spain
Margarita García-Amador
Affiliation:
Bipolar Disorders Program, Institute of Clinical Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBER-SAM, Villarroel 170/Rossello 140, 08036Barcelona, Catalonia, Spain
Oriol Molina
Affiliation:
Bipolar Disorders Program, Institute of Clinical Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBER-SAM, Villarroel 170/Rossello 140, 08036Barcelona, Catalonia, Spain
Miquel Bernardo
Affiliation:
Schizophrenia Clinic Program, Institute of Clinical Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBER-SAM, Villarroel 170/Rossello 140, 08036Barcelona, Catalonia, Spain
Eduard Vieta*
Affiliation:
Bipolar Disorders Program, Institute of Clinical Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBER-SAM, Villarroel 170/Rossello 140, 08036Barcelona, Catalonia, Spain McLean Hospital, Harvard Medical School, Boston, MA, USA
*
* Corresponding author. Bipolar Disorder Program, Institut Clínic de Neurociencies, Hospital Clinic, Universitat de Barcelona, IDIBAPS, Villarroel 170/Rossello 140, 08036 Barcelona, Catalonia, Spain. Tel.: +34 93 2279876; fax: +34 93 2275477.
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Abstract

Introduction

Mixed bipolar states are not infrequent and may be extremely difficult to treat. Lithium, anticonvulsants including valproate and carbamazepine, and antipsychotics such as olanzapine, ziprasidone, and aripiprazole have been reported to be at least partially effective in controlled clinical trials, but many patients do not respond to pharmacological approaches. Electroconvulsive therapy has been tested to be efficacious for the treatment of both manic and depressive episodes, but much less evidence is available with regards to mixed states. The aim of the review was to report the available evidence for the use of electroconvulsive therapy in mixed bipolar states.

Methods

A systematic review of the literature on treatment of mixed states, focused on electroconvulsive therapy, was made, beginning in August 1992 and ending in March 2007. The key words were “electroconvulsive therapy” and “mixed bipolar”.

Results

Only three studies met the required quality criteria and were included. This literature suggests that ECT is an effective, safe, and probably underutilized treatment of mixed states. Recent technical developments have made ECT more friendly, tolerable, and safe. Potential alternatives, such as vagus nerve stimulation, deep brain stimulation, or transcranial stimulation, are still far to be proved as effective as ECT.

Keywords

Bipolar disorderMixed statesECT
Type
Review
Information
European Psychiatry , Volume 23 , Issue 1 , January 2008 , pp. 53 - 56
Copyright
Copyright © Elsevier Masson SAS 2008

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