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Endocrine biomarkers related to sleep-wake cycle and sleep disturbances in patients with bipolar disorder: A systematic review

Published online by Cambridge University Press:  01 September 2022

L. Gonzalez-Blanco ,
C. Moya Lacasa ,
S. Jiménez-Fernández ,
M. Valtueña ,
C. Martinez-Cao ,
A. García Fernández ,
P.A. Saiz ,
M.P. Garcia-Portilla ,
J. Bobes  and
L. Gutierrez Rojas
L. Gonzalez-Blanco
Affiliation:
University of Oviedo, Department Of Psychiatry, oviedo, Spain Servicio de Salud del Principado de Asturias, Psychiatry, Oviedo, Spain Instituto de Investigación Sanitaria del Principado de Asturias, Psychiatry, Oviedo, Spain Instituto de Neurociencias del Principado de Asturias, Psychiatry, Oviedo, Spain Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Psychiatry, Oviedo, Spain
C. Moya Lacasa*
Affiliation:
Servicio de Salud del Principado de Asturias, Psiquiatría, Oviedo, Spain University of Oviedo, Department Of Psychiatry, Oviedo, Spain
S. Jiménez-Fernández
Affiliation:
Complejo Hospitalario de Jaén, Unidad De Salud Mental Infanto Juvenil, Jaén, Spain
M. Valtueña
Affiliation:
University of Oviedo, Department Of Psychiatry, oviedo, Spain
C. Martinez-Cao
Affiliation:
University of Oviedo, Department Of Psychiatry, Oviedo, Spain
A. García Fernández
Affiliation:
University of Oviedo, Department Of Psychiatry, oviedo, Spain
P.A. Saiz
Affiliation:
University of Oviedo, Department Of Psychiatry, oviedo, Spain
M.P. Garcia-Portilla
Affiliation:
University of Oviedo, Department Of Psychiatry, oviedo, Spain
J. Bobes
Affiliation:
University of Oviedo, Department Of Psychiatry, oviedo, Spain
L. Gutierrez Rojas
Affiliation:
Hospital Clínico San Cecilio, Psychiatry, Granada, Spain
*
*Corresponding author.

Abstract

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Introduction

Sleep and circadian disturbances have been widely studied in patients with bipolar disorder (BD) (Duarte Faria et al., 2015; Gonzalez, 2014). However, there is no clear evidence about the role of peripheral biomarkers of circadian cycle in this population.

Objectives

This systematic review aims to identify potential endocrine biomarkers of circadian rhythm in blood and study their relationship with sleep problems in BD.

Methods

An electronic search of Pubmed and PsycoInfo databases were performed. It includes articles about the topic from 1991 to 2021. The search strategy was: (“Peripheral biomarkers” OR “biological markers” OR biomarker OR cortisol OR melatonin OR orexin OR hypocretin) AND (blood OR serum OR plasma) AND (“sleep-wake” OR “circadian rhythm” OR sleep OR insomnia) AND “bipolar”.

Results

92 records were obtained after excluding duplicates. Only five studies met the inclusion criteria (n = 499; BD = 125; unipolar depression = 148; schizophrenia = 80; controls = 146). The endocrine parameters analyzed were: cortisol (3 studies), melatonin (1 study) and orexin-A (1 study). Overall, no significant associations between these biomarkers and sleep disturbances, assessed with subjective (psychometric evaluation) and/or objective (polysomnography) measures, were detected.

Conclusions

This systematic review highlights the lack of studies that explores the role of endocrine biomarkers related to circadian function in the pathophysiology of sleep disturbances in BD.

Disclosure

No significant relationships.

Keywords

circadian rhythmssleep disordersorexinmelatonin
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S360
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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