EPA-1016 - Comparative Analysis of Some Inflammation Mediators in Alzheimer's Disease and Schizophrenia in Aged

Abstract

Research of the last decade established that inflammatory reactions are involved in the pathogenesis of Alzheimer's disease (AD) and schizophrenia (Sch).

The aim of this paper to carry out a comparative analysis of some inflammation mediators [activity of leukocyte elastase (LE) and alpha 1- proteinase inhibitor (α1-PI), the level of CRP, IL-6 and IL-10] in the blood serum in patients with AD and in old aged patients with schizophrenia in comparison with healthy control of the same age.

There were a significant increase in activity of α1-PI, level of CRP, IL-6 and IL-10 (p<0.0001, p<0.05, p<0.01, p<0.01, respectively) and significant decrease of LE activity (p<0.0001) in the group of patients with AD compared to control. The activity of LE was positive correlated with MMSE scores (r =0.34, ?=0.0487) and the IL-6 level was negative correlated with MMSE scores (r =-0.46, ?=0.0077), ie cognitive decline was associated with decreased activity of LE and increased levels of IL-6. The group of patients with Sch was characterized only by a significant increase in activity α1-PI and level of CRP compared to control (p<0.0001, p<0.01, respectively). LE activity and IL-6 level in patients with AD significantly differ from patients with schizophrenia (p<0.05, p<0.01, respectively).

Thus, the low activity LE and high levels of IL-6 are observed only for patients with AD, but not for patients with schizophrenia. These parameters may serve as biological markers of the severity of AD.