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EPA-1046 – Antipsychotics Promote the Differentiation of Oligodendrocyte Progenitor Cells by Regulating Oligodendrocyte Lineage Transcription Factors 1 and 2

Published online by Cambridge University Press:  15 April 2020

Y. Zhang ,
H.D. Zhang ,
F. Fang ,
H.Y. Xu ,
L. Kong ,
Z.J. Zhang ,
D. Zhang ,
Y. Liu ,
Z.J. Huang  and
X.M. Li
Y. Zhang
Affiliation:
Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada
H.D. Zhang
Affiliation:
Mental Health Center, Shantou University, Shantou, China
F. Fang
Affiliation:
Department of Nutrition School of Public Health, Jilin University, Changchun, China
H.Y. Xu
Affiliation:
Mental Health Center, Shantou University, Shantou, China
L. Kong
Affiliation:
Department of Psychiatry Faculty of Medicine, University of Manitoba, Winnipeg, China
Z.J. Zhang
Affiliation:
Department of Neuropsychiatry, Southeast University, Nanjing, China
D. Zhang
Affiliation:
Institute of Mental Health, Peking University, Beijing, China
Y. Liu
Affiliation:
Department of Nutrition School of Public Health, Jilin University, Changchun, China
Z.J. Huang
Affiliation:
Mental Health Center, Shantou University, Shantou, China
X.M. Li
Affiliation:
Department of Psychiatry, University of Alberta, Edmonton, Canada

Abstract

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Introduction:

Antipsychotic drugs (APDs) are the first-line pharmacological treatments for schizophrenia. Recent human studies have found that myelin integrity could be improved by APD treatment in schizophrenia patients. Previous studies indicated that regulation of oligodendrocyte development and function may be a novel target for APDs.

Aims:

The aim of this current study was to examine the possible effects of the antipsychotic drugs (APDs) haloperidol (HAL), olanzapine (OLA), and quetiapine (QUE) on the development of oligodendroglial lineage cells.

Main methods:

CG4 cells, an oligodendrocyte progenitor cell line, were treated with various concentrations of HAL, OLA, or QUE for specific periods. The proliferation and differentiation of the CG4 cells were measured. The regulation of CG4 cell differentiation by oligodendrocyte lineage transcription factors 1 and 2 (Olig1 and Olig2) was examined.

Results:

The APDs used in this study had no effect on the proliferation of CG4 cells. The APDs elevated the expression of 2’,3’-cyclic nucleotide 3’-phosphodiesterase (CNP), a specific marker of oligodendrocytes, and promoted the CG4 cells to differentiate into CNP positive oligodendrocytes. QUE and OLA increased the expression of Olig1 and Olig2 whereas HAL only increased the expression of Olig2.

Conclusions:

Our findings suggest that oligodendrocyte development is a target of HAL, OLA, and QUE and provide further evidence of the important role of oligodendrocytes in the pathophysiology and treatment of schizophrenia. They also indicate that the expression level of oligodendrocyte/myelinrelated genes could be profoundly affected by APDs.

Type
FC09 - Free Communications Session 09: Genetics and molecular neurobiology
Information
European Psychiatry , Volume 29 , Issue S1: Abstracts of the 22nd European Congress of Psychiatry , 2014 , pp. 1
Copyright
Copyright © European Psychiatric Association 2014
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