Factors of premorbid period indicating the risk of medicated noncompliance in patients with schizophrenia

Abstract

Background

Methods of assessment of medicated compliance are based upon preceding experience of taking therapy and cannot be applied at the first admission.

Objective

To investigate premorbid characteristics in schizophrenic patients and reveal the factors indicating noncompliance.

Methods

We used medical record background, interview, Medical Compliance Prediction Scale for Psychiatry for evaluation of the level of compliance, program STATISTICA10 for identification of the average level of compliance in the subgroups of each factor by Kruskal–Wallis test and revealing those subgroups for each factor where the average level of compliance was statistically significantly lower (P < 0.05).

Results

We examined 120 patients (status corresponded to the ICD-10 diagnostic criteria for schizophrenia, age–18 and older, duration of the disease–5 years and more, patients taking typical or atypical antipsychotics or combined therapy) according to factors of premorbid period such as gender, family history of mental disorders, personality traits, nurture in the family, education level, marital status; substance use, age at the onset of disease.

Conclusions

Level of compliance was lower in subgroups of men, patients having several relatives with mental disorders, patients having personality with predominance of irritable and impulsive traits, patients with neglect in parental families, patients with education level lower than high school and with education level higher than bachelor; patients not working or studying to onset of disease; patients who were divorced or widowed; patients living alone; patients using psychoactive substances; patients aged 21 years and older to the onset of disease.

Disclosure of interest

The authors have not supplied their declaration of competing interest.