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Failure of fixed-dose verapamil treatment in adult sleep-related enuresis

Published online by Cambridge University Press:  16 April 2020

A Grinshpoon ,
M Mark ,
A Apter ,
I Modai ,
A Bleich ,
M Rehavi  and
A Weizman
A Grinshpoon
Affiliation:
Mental Health Center, Israel Defense Forces, Israel
M Mark
Affiliation:
Mental Health Center, Israel Defense Forces, Israel
A Apter
Affiliation:
Geha Psychiatric Hospital, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv
I Modai
Affiliation:
Geha Psychiatric Hospital, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv
A Bleich
Affiliation:
Mental Health Center, Israel Defense Forces, Israel
M Rehavi
Affiliation:
Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv
A Weizman*
Affiliation:
Geha Psychiatric Hospital, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv Felsenstein Medical Research Center, and Geha Psychiatric Hospital, Beilinson Campus, Petah Tiqva, Israel
*
*Correspondence and reprints.
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Summary

Calcium channel blockers increase the capacity of the urinary bladder. The antienuretic activity of verapamil was examined in young adult enuretics. Eleven drug-free, healthy, sleep-related enuretic males, were treated for two weeks with verapamil (240 mg, per os, at 9 pm). Verapamil failed to display an antienuretic effect.

Keywords

enuresisverapamilimipramine
Type
Rapid communication
Information
European Psychiatry , Volume 9 , Issue 2 , 1994 , pp. 101 - 103
Copyright
Copyright © European Psychiatric Association 1994

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References

Ruth, LLavietes, M. Functional enuresis.In: Kaplan, HSadock, B. Comprehensive Textbook of Psychiatry. 5th edn. Baltimore: Williams and Wilkins, 1989:1879-82Google Scholar
Ferrie, BGMacFarlane, JGlen, ES. DDAVP in young enuretic patients: a double blind trial. Br J Urol 1984;56:376-8CrossRefGoogle ScholarPubMed
Ramsden, PDHindmarsh, JRPrice, DAYates, WKBowditch, JDP. DDAV for adult enuresis - a preliminary report. Br J Urol 1982;54:256-8CrossRefGoogle Scholar
Weizman, ACarel, CTyano, SRehavi, M. Decreased high affinity 3H-imipramine binding in platelets of enuretic children and adolescents. Psychiatry Res 1985;14:39–46CrossRefGoogle ScholarPubMed
Rehavi, MCarmi, RWeizman, A. Tricyclic antidepressants and calcium channel blockers: interactions at the (-)desmethoxy-verapamil binding site and the serotonin transporter. Eur J Pharmacol 1988;155:1–9CrossRefGoogle Scholar
Akah, PA. Tricyclic antidepressant inhibition of the electrical evoked responses of the rat urinary bladder strip-effect of variation in extracellular Ca2+ concentration. Arch Int Pharmacodyn Ther 1986;284:231-5Google ScholarPubMed
Shapiro, ETany, RRosenthal, ELepor, H. The binding and functional properties of voltage dependent calcium channel receptors in pediatric normal and myeloplastic bladders. J Urol 1991;146:520-3CrossRefGoogle Scholar
Belis, JACurley, RMWagner, CHMurty, VNWinter, SJRosner, TJ Jr. Neurogenic function of the diabetic rat bladder: alteration by calcium channel effectors. Pharmacology 1991;43:273-81CrossRefGoogle ScholarPubMed
Goton, MHassouna, MElhilali, M. Intravesical instillation of verapamil and its effect on detrusor contractility. In vitro and in vivo studies. J Urology 1986;135:218AGoogle Scholar
Babu, RVaidyanathan, SSankaranarayan, AIndudhara, R. Effect of intravesical instillation of varying doses of verapamil (20 mg, 40 mg, 80 mg) upon urinary bladder function in chronic traumatic paraplegics with overactive detrusor function. Int Clin Pharmacol Ther Toxicol 1990;28:350-4Google ScholarPubMed
Mattiason, AErstrom, BAndersson, RE. Effects of intravesical instillation of verapamil in patients with detrusor hyperactivity. Neurol Urodyn 1987;6:253-4Google Scholar
Andersson, REFovaeus, MMorgan, EDMcLorie, G. Comparative effects of five calcium channel blockers on the atropine resistant contraction in electrically stimulated rabbit urinary bladder. Neurol Urodyn 1987;5:579-86CrossRefGoogle Scholar
Rud, TAnderson, REUlmster, U. Effects of nifedipine in women with unstable bladders. Urol Int 1979;34:421-9CrossRefGoogle ScholarPubMed
Palmer, TWorth, PExton-Smith, A. Flunarizine: a once-daily therapy for urinary incontinence. Lancet 1981;8:279-81CrossRefGoogle Scholar
Laval, KLutzeyer, W. Spontaneous phasic activity of the detrusor: a cause of uninhibited contractions in unstable bladder. Urol Int 1980;35:182-7CrossRefGoogle Scholar
Elmer, M. Terodiline in children with diurnal enuresis. Scand J Urol Nephrol (suppl):1984;59–61Google Scholar
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