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Features of infllammatory reactions and clinical picture in elderly and young patients with schizophrenia

Published online by Cambridge University Press:  13 August 2021

L. Androsova ,
A. Barkhatova ,
V. Sheshenin ,
S. Zozulya ,
I. Otman ,
V. Pochueva  and
T. Klyushnik
L. Androsova*
Affiliation:
Laboratory Of Neuroimmunology, Mental Health Research Centre, Moscow, Russian Federation
A. Barkhatova
Affiliation:
Department For The Study Of Endogenous Mental Disorders And Affective States, Mental Health Research Centre, Moscow, Russian Federation
V. Sheshenin
Affiliation:
Department Of Gerontological Psychiatry, Mental Health Research Centre, Moscow, Russian Federation
S. Zozulya
Affiliation:
Laboratory Of Neuroimmunology, Mental Health Research Centre, Moscow, Russian Federation
I. Otman
Affiliation:
Laboratory Of Neuroimmunology, Mental Health Research Centre, Moscow, Russian Federation
V. Pochueva
Affiliation:
Department Of Gerontological Psychiatry, Mental Health Research Centre, Moscow, Russian Federation
T. Klyushnik
Affiliation:
Laboratory Of Neuroimmunology, Mental Health Research Centre, Moscow, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

It is known that the intensity of inflammation weakens with age, and therefore it is of interest to study the clinical features of schizophreniс process in relation to the level of inflammatory markers.

Objectives

To determine the level of inflammatory markers (the activity of leukocyte elastase (LE) and α1-proteinase inhibitor (α1-PI), autoantibodies (aAB) to neurotrophin S100b and myelin basic protein) in plasma in different years old groups of patients with schizophrenia.

Methods

Two groups of patients with schizophrenia were examined: the 1st group - 19 women aged 60 to 78 years; the 2nd group - 24 women aged 19 to 42 years.

Results

An increase in activity both of LE and α1-PI was found in young patients. This characterizes a balanced inflammatory response. Elderly patients showed a similar increase in the activity of α1-PI, however, LE activity did not exceed the control values. Insufficient LE activity probably characterizes a decrease in the functional activity of neutrophils. The negative correlation was revealed between the activity of LE and TotPsy (PANSS) in the group of elderly patients (r=-0.62, p<05) and positive correlation between aAB to S100b and TotNeg in both groups (r=0.56 and r=0.49, p<05 respectively). There is relationship between age, the activity of psychopathological symptoms and the rate of development of schizophrenia: the rapid course and variety of disorders at a young age, against the poverty of symptoms and a slow rate in the elderly.

Conclusions

There is relationship between the features of inflammatory reactions and clinical picture in elderly and young patients with schizophrenia.

Keywords

schizophrenia at young and old ageinflammatory markers
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S473
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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