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Features of the influence of hereditary factors on the clinical manifestations of depressive disorders

Published online by Cambridge University Press:  13 August 2021

N. Maruta ,
S. Kolyadko ,
V. Fedchenko  and
I. Yavdak
N. Maruta*
Affiliation:
Borderline Psychiatry, “Institute of Neurology, Psychiatry and Narcology of NAMS of Ukraine” SI, Kharkiv, Ukraine
S. Kolyadko
Affiliation:
Borderline Psychiatry, “Institute of Neurology, Psychiatry and Narcology of NAMS of Ukraine” SI, Kharkiv, Ukraine
V. Fedchenko
Affiliation:
Borderline Psychiatry, “Institute of Neurology, Psychiatry and Narcology of NAMS of Ukraine” SI, Kharkiv, Ukraine
I. Yavdak
Affiliation:
Borderline Psychiatry, “Institute of Neurology, Psychiatry and Narcology of NAMS of Ukraine” SI, Kharkiv, Ukraine
*
*Corresponding author.

Abstract

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Introduction

The urgency of the problem of depression is due to their high prevalence and severity of consequences. At present, the pathogenetic role of heredity in the course of depressive disorders remains unclear. Therefore, studies related to this problem are designed to identify the relationship between hereditary factors and the characteristics of the clinic of depression.

Objectives

The aim was to study the features of the influence of hereditary factors on the clinic of depressive disorders.

Methods

clinical-psychopathological, psychometric, genealogical, statistical.

Results

Based on the study of clinical, psychometric (Hamilton scale (HDRS)), genealogical data of 87 patients with depression, a high level of family burden of depression at all levels of kinship in the pedigree of patients (73.56%), alcohol abuse (39.08%), the presence of hypertension (54.02%), heart disease (42.53%) and endocrine pathology (14.94%) were identified. Moreover, in the pedigree of the examined most often this pathology was found in relatives of I and II degree of kinship. When comparing the factors of heredity with the clinical structure and features of depression revealed the proportion of correlations of such factors as: observation by a psychiatrist of I and II degree of relatedness (p ≤ 0.01), depressive disorders mainly by II degree of relatedness (p ≤ 0.05), suicidal behavior according to I and II degree of kinship (p ≤ 0.005), alcohol dependence mainly on I degree of kinship (p ≤ 0.03). Selected leading symptom complexes: depressive, asthenic, apathetic, anxiety-phobic, somato-vegetative, hypochondriac.

Conclusions

The data obtained should be taken into account in diagnostic and preventive measures.

Keywords

depressionhereditary factors
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S331
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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